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poster

MMM 2022

November 07, 2022

Minneapolis, United States

Biocompatible Superparamagnetic NiFe2O4 Nanoparticles for Magnetic Hyperthermia Treatment using a ZVS Circuit

Nanosized magnetic materials form a single domain and, as a result, magnetic nanoparticles (MNPs) usually lose their ferromagnetic properties. However, superparamagnetic NPs can generate sufficient heat to kill cancer cells under a weak magnetic field. In this study, NiFe2O4 NPs with particle sizes of 3–17 nm were prepared for application in magnetic hyperthermia treatment (MHT), and their biocompatibility was improved by modification with polyethylene glycol (PEG). PEG is hydrophilic and is often used in the medical field. Direct current (DC) magnetization measurements showed that all the samples exhibited no hysteresis or superparamagnetic behavior at 300 K. The temperature dependence of the alternating current (AC) magnetic susceptibilities revealed that the peak temperature of the imaginary part of AC magnetic susceptibilities (χ") varied significantly with particle size, and the 17 nm sample had a peak at approximately 310 K. It is known that χ" contributes significantly to heat generation owing to magnetic relaxation losses. The temperature increase of the samples under an AC magnetic field (f = 15 kHz, h = 150 Oe) was measured. The sample with 17 nm particles showed a significant heating effect compared to the other samples, reaching over 42.5 °C, which is sufficient to suppress cancer cells. Human breast cancer cells (MDA-MB-231) were cultured on a petri dish, and PEG-coated NiFe2O4 NPs were added. The sample was heated using an AC magnetic field. Approximately 30% of cancer cells were successfully killed, and the magnetic hyperthermia effect was confirmed (Fig.1). To evaluate the toxicity of PEG-coated magnetic NPs toward cancer cells, cell viability was observed for 24 h after the particles were dispersed in the culture dishes. PEG-coated NiFe2O4 NPs successfully improved biocompatibility. Thus, NiFe2O4 NPs are expected to be useful agents for MHT. By using a zero-voltage switching (ZVS) circuit and generating an AC magnetic field from a DC power source, a temperature rise two to eight times higher than that using conventional coils was achieved (Fig.2).

References:

P. Das, M. Colombo, D. Prosperi, Coll. Surf. B 174, 42 (2019)

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