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Abstract Title: Mortality and Complications in Patients with Chronic Kidney Disease (CKD) Following Lower Extremity Trauma
Authors: Margaret Fisher MS, Jason McCartney BS, Kristin A Toy MD, MS, Beau White MD, Di Hu MS, Feng-Chang Lin PhD, Judith Siegel MD, Robert Ostrum MD, Andrew Chen MD, MPH

Background: Moderate-to-severe chronic kidney disease (CKD) and end-stage renal disease (ESRD) are independent risk factors for sustaining a fragility fracture due to abnormalities within bone structure and metabolism. This study aims to assess complications in these patients following surgical management of all lower extremity fractures, as previous studies have largely focused on only hip fractures. 

Methods: This was a single-center, retrospective study of patients with CKD/ESRD who underwent operative management of lower extremity fractures between 2008-2019. Patients were stratified into three cohorts by CKD stages using estimated glomerulus filtration rate (GFR) at the time of surgery (mild (stages 1-2); GFR ≥ 60, moderate-severe (stages 3-4); GFR 15-59, ESRD (stage 5); GFR &lt;15 or dialysis). Charlson Comorbidity Index (CCI) and fracture characteristics were collected. Outcomes of interest including minor complications (DVT, cellulitis, delayed wound healing), major complications (hardware failure, nonunion/malunion, deep infection, peri-implant fracture), and 2-year mortality were compared between cohorts using Chi-squared, ANOVA, and Fisher’s exact tests. A multivariable logistic regression assessed independent associations of moderate-severe CKD/ESRD on mortality and complications. 

Results: 356 patients with fractures of the pelvis/acetabulum (4.6%), hip (28.0%), femoral/tibial shafts (18.0%), peri-articular (22.4%), ankle (25.1%) and patella (1.9%) were included. Demographics were similar between cohorts except for age, race, and CCI. Mortality rates were significantly different between ESRD and mild CKD groups at 90 days (15.7% vs. 5.5%; p=.033), 1 year (27.1% vs. 10.5%; p=.005), and 2 years (47.1% vs. 17.0%; p&lt;.0001). Overall complications and major complications were higher with increasing CKD severity (14.8%, 31.0%, 40.7%, p&lt;0.0001 and 13.3%, 22.5%, 33.9%, p&lt;0.001). After adjusting for CCI, multivariate analysis demonstrated a positive association between ESRD and mortality at 90 days (OR 4.5, 95%CI 1.3, 15.1), 1 year (OR 2.7, 95%CI 1.1, 6.5) and 2 years (OR 5.2, 95%CI 2.3, 11.6). Complications were associated with moderate/severe CKD (OR 2.2, 95% CI 1.1, 4.3, p=.0004) and ESRD (OR 4.1, 95%CI 1.8, 9.4, p&lt;.0001). 

Conclusion: This study demonstrates high mortality and complication rates for patients with moderate-to-severe CKD who undergo operative fixation of a lower extremity fracture. These findings can be used to counsel patients regarding realistic expectations of complications.


AMA Research Challenge 2022

Mortality and Complications in Patients with Chronic Kidney Disease Following Lower Extremity Trauma

Welcome to the largest national, multi-specialty research event **featuring research from 750 medical students, residents and fellows, and international medical graduates.**


#### Event Details
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Ricardo Correa, MD, EdD
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Jessica Li, MD/PhD Candidate
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Charles Lopresto, DO

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Welcome to the largest national, multi-specialty research event featuring research from 750 medical students, residents and fellows, and international medical graduates.


Abstract Title: Mortality and Complications in Patients with Chronic Kidney Disease (CKD) Following Lower Extremity Trauma
Authors: Margaret Fisher MS, Jason McCartney BS, Kristin A Toy MD, MS, Beau White MD, Di Hu MS, Feng-Chang Lin PhD, Judith Siegel MD, Robert Ostrum MD, Andrew Chen MD, MPH

Background: Moderate-to-severe chronic kidney disease (CKD) and end-stage renal disease (ESRD) are independent risk factors for sustaining a fragility fracture due to abnormalities within bone structure and metabolism. This study aims to assess complications in these patients following surgical management of all lower extremity fractures, as previous studies have largely focused on only hip fractures. 

Methods: This was a single-center, retrospective study of patients with CKD/ESRD who underwent operative management of lower extremity fractures between 2008-2019. Patients were stratified into three cohorts by CKD stages using estimated glomerulus filtration rate (GFR) at the time of surgery (mild (stages 1-2); GFR ≥ 60, moderate-severe (stages 3-4); GFR 15-59, ESRD (stage 5); GFR <15 or dialysis). Charlson Comorbidity Index (CCI) and fracture characteristics were collected. Outcomes of interest including minor complications (DVT, cellulitis, delayed wound healing), major complications (hardware failure, nonunion/malunion, deep infection, peri-implant fracture), and 2-year mortality were compared between cohorts using Chi-squared, ANOVA, and Fisher’s exact tests. A multivariable logistic regression assessed independent associations of moderate-severe CKD/ESRD on mortality and complications. 

Results: 356 patients with fractures of the pelvis/acetabulum (4.6%), hip (28.0%), femoral/tibial shafts (18.0%), peri-articular (22.4%), ankle (25.1%) and patella (1.9%) were included. Demographics were similar between cohorts except for age, race, and CCI. Mortality rates were significantly different between ESRD and mild CKD groups at 90 days (15.7% vs. 5.5%; p=.033), 1 year (27.1% vs. 10.5%; p=.005), and 2 years (47.1% vs. 17.0%; p<.0001). Overall complications and major complications were higher with increasing CKD severity (14.8%, 31.0%, 40.7%, p<0.0001 and 13.3%, 22.5%, 33.9%, p<0.001). After adjusting for CCI, multivariate analysis demonstrated a positive association between ESRD and mortality at 90 days (OR 4.5, 95%CI 1.3, 15.1), 1 year (OR 2.7, 95%CI 1.1, 6.5) and 2 years (OR 5.2, 95%CI 2.3, 11.6). Complications were associated with moderate/severe CKD (OR 2.2, 95% CI 1.1, 4.3, p=.0004) and ESRD (OR 4.1, 95%CI 1.8, 9.4, p<.0001). 

Conclusion: This study demonstrates high mortality and complication rates for patients with moderate-to-severe CKD who undergo operative fixation of a lower extremity fracture. These findings can be used to counsel patients regarding realistic expectations of complications.

poster

Background
Distal femur fractures (DFFs) represent approximately 1% of all fractures and 3-6% of femur fractures. Management of DFFs can be challenging, particularly in the aged female population due to predisposition to osteoporosis and osteopenia and higher risk of other comorbidities. This retrospective study aims to analyze the surgical outcomes of aged female patients with non-periprosthetic DFFs treated with a locking plate (LP).

Methods
Fifty-five female patients (mean age of 71 years) with non-periprosthetic DFF underwent open reduction internal fixation using a LP from 2005 to 2019. The mean follow-up time was 67 weeks from the date of injury. Criteria used for diagnosis of nonunion included one or more of the following: (1) three consecutive months without progression of healing on postoperative radiographs, (2) a total of nine months without complete healing, or (3) physician-diagnosed nonunion using clinical judgement. Outcome data was analyzed and compared amongst patients with and without obesity or diabetes. Statistical analysis was performed with a standard statistically significant p-value of < 0.05.

Results
Thirty-two patients (58%) with DFF achieved union after initial treatment while 23 patients (42%) resulted with nonunion. 14 patients (61%) underwent revision with nine of these patients (64%) achieving union while five patients (36%) had persistent nonunion. Average healing time from initial treatment was 29 weeks, while average time from definitive treatment to union was 22 weeks. Obese (BMI >30) and non-obese patients had a nonunion rate of 65% and 28%, respectively (p = 0.008). Patients with diabetes had a nonunion rate of 65%, while patients without diabetes had a nonunion rate of 28% (p = 0.008).

Conclusion
Union can be successfully achieved in aged female patients with distal femur fractures treated with locking plate. However, the risks for nonunion and revision remain high and patients with obesity and diabetes appear to be at an increased risk. Further research should be conducted with a prospective study or multivariate analysis and increased number of patients to reaffirm this data.

Obesity and Diabetes in Distal Femur Fracture Treatment with Locking Plate

Background: Patellar Tendinopathy (Jumper’s Knee) affects up to 17% of the general population and may become recalcitrant in up to 20% of cases. While these cases often require surgery, it is unclear whether an open or arthroscopic procedure should be performed.

Methods: A systematic search of articles published 2000-present studying outcomes after surgical intervention for patellar tendinopathy was performed across PubMed, Embase, CINAHL, Scopus, and Cochrane databases and screened using PRISMA guidelines. Outcomes assessed included Patient Reported Outcome Measures (PROM), ie Victorian Institute of Sports Assessment (VISA-P), Visual Analog Scale (VAS), modified Blazina, Lysholm, Tegner, IKDC, and SANE scores, and subjective Success and Return to Sport (RTS) data at follow-up. Descriptive statistics with weighted averages were used to assess differences between groups but no meta-analysis was performed due to heterogeneity of intervention groups. 

Results: 21 studies were included for analysis that analyzed 13 arthroscopic, 8 open, and 2 combined treatment groups with follow-up ranging from 6-96 months. 2 retrospective studies directly compared open vs arthroscopic and reported earlier RTS time in arthroscopic patients (mean 5.5 vs 8.0mo) but no differences in VISA-P, overall success, or RTS rate. Open surgical patients required repeat surgery in 4 instances. Summary analysis of all data showed arthroscopic patients had earlier RTS (3.8 vs 8.7mo) and slightly higher RTS rate (88.5% vs 74.9%), but similarly high rates of overall success (89.1% vs 83.1%). Arthroscopic groups generally had higher average VISA-P and Blazina scores compared to Open groups. Combined open/arthroscopic procedures exhibited a mean success and RTS rate of 86.6% and 91.3%. Complications were reported in 3 open groups (surgical site complication, repeat surgery required, algodystrophy), 2 arthroscopic groups (failed tendon release, new-onset PFPS), and 1 combined group (repeat surgery required). 

Conclusions: In patients with refractory patellar tendinopathy and varying baseline activity levels, both open and arthroscopic surgical approaches, as well as combined procedures, lead to high rates of success and return to sport. Arthroscopic approaches may lead to quicker return to sport and greater improvements in patient-reported outcome measures than open procedures. 

Clinical Relevance: Arthroscopic intervention may yield similar or better clinical outcomes compared to open techniques with quicker return to sport for patellar tendinopathy refractory to conservative management.

Open versus Arthroscopic Management of Patellar Tendinopathy

Case: Three skeletally immature patients with scoliosis with a thoracolumbar/lumbar Cobb angle ≥40º, Risser grade 0, who had lumbar posterior spinal tethering (PST) performed by a single surgeon at an academic medical center from 2018-2022 are included in this report. 
Conclusion: This is the first paper to describe outpatient PST. At minimum 21 months postoperatively, the three outpatient PST patients had significantly reduced Cobb angles (p=0.002), decreased pain (p=0.04), no complications, no revisions, and reported being able to return to both daily life and sport. Outpatient PST may be a less morbid surgical approach to pediatric scoliosis in select patients.


Posterior Spinal Tethering as an Outpatient Surgical Option for the Treatment of Select Cases of Pediatric Scoliosis: A Report of 3 Cases

Predicting 10-Year Risk of Osteoporosis in Pre- and Perimenopausal Women

Background: Minimal clinically important differences (MCID) reflect significant changes in the health-
related quality of life after a clinical intervention. Although MCID is widely used in spine literature, few studies have been done to establish the radiographic and clinical predictors of achieving MCID in elderly
patients undergoing surgery for adult spinal deformity (ASD) correction. This study assesses preoperative and post-operative radiographic parameters, comorbidities and peri-operative complications as potential predictors of MCID in elderly patients ≥65yr with ASD. We hypothesized that patients who failed to meet MCID thresholds for ASD surgery are more likely to have significant
preoperative spinal imbalance and clinical co-morbidities.

Methods: Patients included were ≥65yr with ASD, had ≥5 levels fusion including the lumbosacral junction, and had complete preoperative, postoperative and 2yr Oswestry Disability Index (ODI), Visual Analog Scale (VAS), and radiographic measurements. Patients with 2yr postoperative improvement of ODI >10 or VAS >2.5 when compared with preoperative baseline were considered to meet MCID. A Student t test was used to assess the difference of variables across patients that achieved MCID and those that did not.

Results:104 patients ≥65yr surgically managed for ASD were separated into 2 cohorts: 67 patients that met MCID and 37 patients that did not. Patients that met MCID had significantly lower preoperative sagittal alignment (8.66 vs 11.88 cm, p=0.05) when compared with those without improvement. Other preoperative radiographic parameters such as coronal balance and T1-pelvic angle were not significantlydifferent. Post-operative radiographic parameters were all similar between the two groups. Patients meeting MCID had a lower rate of previous spinal surgery (22.3%) vs the non-improved group (51.4%) (p<0.01). The MCID group also had a lower rate of pre-existing stroke (3%) compared with the non- improved group (13.5%) (p=0.04). Achieving MCID is also more likely in patients with scoliosis as
compared to kyphosis (84% vs 45% p=0.03).

Conclusion: Preoperative sagittal mal-alignment, a predominantly kyphotic deformity, revision surgery,
and a history of stroke are predictive of failure to meet MCID in deformity surgery for patients ≥65yr. Knowledge of these characteristics can be beneficial in counseling patients about prognosis after surgery and post-operative expectations.

Predictors of Minimally Clinical Importance Difference in Elderly Patients (≥ 65 years of age) Undergoing Spinal Deformity Surgery

Background. The peroneus longus (PL) and peroneus brevis (PB) tendons comprise the lateral compartment of the leg and work to stabilize the foot during weight-bearing. Peroneal tendinopathy can precipitate persistent lateral ankle pain and induce substantial functional disability. The process by which peroneal pathology can progress to significant lateral ankle dysfunction is thought to stem from asymptomatic, subclinical peroneal tendinopathy. As such, there is substantial clinical benefit to identifying asymptomatic patients with this condition before it progresses to disability. Various ultrasound (US) characteristics have been observed in peroneal tendinopathy. The purpose of this study is to identify the frequency of subclinical tendinopathic characteristics in asymptomatic peroneal tendons. 
Methods. A total of 170 participants underwent bilateral US examination of the foot and ankle. These images were assessed for abnormalities of the PL and PB tendons by a group of physicians, and frequencies of abnormalities were recorded. This team consisted of an orthopedic surgeon specializing in foot and ankle surgery, a fifth-year orthopedic surgery resident, and a family medicine physician with musculoskeletal sonographer certification.
Results. 340 PL and 340 PB tendons were assessed. Of these, 68 (20%) PL and 41 (12.1%) PB tendons had abnormal traits. Specifically, 24 PLs (7.1%) and 22 PBs (6.5%) had circumferential fluid, 16 PLs (4.7%) and 9 PBs (2.6%) had noncircumferential fluid, 27 PLs (7.9%) and 6 PBs (1.8%) had thickening, 36 PLs (10.6%) and 12 PBs (3.5%) had heterogenicity, 10 PLs (2.9%) and 2 PBs (0.6%) had hyperemia, and 1 PL (0.3%) had calcification. 
Conclusion. Of the 170 participants, 34% had at least one abnormal PL characteristic identified on US. Twenty-two percent of participants were found to have at least one abnormal PB trait. In the study population, heterogenicity was the most prevalent abnormality found in PL tendons, while circumferential fluid was the most common abnormal trait in PB tendons. Understanding the frequency of abnormalities in asymptomatic peroneal tendons may aid clinicians in identifying subclinical tendinopathy before it progresses to dysfunction.

Prevalence of Abnormal Ultrasound Findings in Asymptomatic Peroneal Tendons

Background: Scoliosis is a common spinal malformation, which is typically diagnosed and assessed for severity by measuring the Cobb angle on a plain radiograph. Although manual methods are still considered the gold standard, recent studies have shown that PACS (picture archiving and communication systems methods) have comparable intraobserver and interobserver reliability levels for experienced clinicians. However, there is limited data for these reliability measures in less experienced medical personnel, especially with digital methods like PACS.

Methods: 10 radiographic images of scoliosis patients were obtained via a retrospective chart review. After a brief training exercise, Cobb angle measurements were performed twice on each radiograph, separated by one week, using the PACS method. Subject groups ranged in their level of prior training and experience with Cobb angle measurements from inexperienced medical students, to more experienced resident physicians, and highly experienced orthopedic surgeons and radiologists. Data was compared for interrater reliability levels within groups and between groups, and for individual intra-rater reliability levels. Intra-class correlation coefficient (ICC) between averaged measured were calculated and a Cronbach’s α obtained. An α of ≥ 0.9 is considered excellent agreement, 0.9 > α ≥ 0.8 is good, 0.8 > α ≥ 0.7 is acceptable, 0.7 > α ≥ 0.6 is questionable and α < 0.6 is poor or unacceptable reliability. 

Results: Resident physicians, orthopedic surgeons, and radiologist subject groups had significant levels of between-group and within-group inter-rater reliability as well as individual intra-rater reliability levels (α ≥ 0.9, p<0.001). Inexperienced medical student raters had poor within-group interrater reliability (α = -0.176). One medical student had a significant level of individual intra-rater reliability (α > 0.9, p<0.001) while the other had poor intra-rater reliability (α < 0.6, p=0.035). Between-group inter-rater reliability for medical students and more experienced professionals was poor (α < 0.6).

Conclusions: While PACS has been shown to be a reliable method for measuring Cobb angle and an acceptable substitute for conventional manual techniques, it is not a reliable method in less experienced trainees such as medical students.

Reliability of Cobb angle measurement using PACS in less-experienced medical personnel

Abstract Title: 
Reverse Total Shoulder Arthroplasty: The Impact of Implant Design on Postoperative Internal Rotation

Background
Reverse total shoulder arthroplasty (rTSA) is a ubiquitous surgical procedure indicated for numerous glenohumeral pathologies. Repeated evidence demonstrates its efficacy in improving shoulder function and reducing pain; however, improvements in rotational motion have been inconsistent. Attention has recently shifted toward internal rotation (IR) as an important component of activities of daily living (ADL). Subsequently, IR has been strongly associated with post-operative patient satisfaction. To date, there has been little discussion regarding implant design on IR. As the community shifts toward more lateralized center-of-rotation and varus humeral implants, it is unclear how this will impact rotational motion.

Methods
A systematic review was performed following PRISMA guidelines. Search strategies were implemented in PubMed with the keywords (internal rotation) AND (reverse) AND (shoulder). Inclusion criteria included a minimum 12-month follow-up, reporting of IR, and implant description. Exclusion criteria included rTSA solely for proximal humerus fractures, oncologic reconstruction, or severe glenoid deformity, revision rTSA, and procedures including latissimus dorsi or tendon transfers. After review, 56 studies from 332 unique citations were selected.

Results
Analysis was performed on 56 studies consisting of 7788 shoulders treated with rTSA at a mean follow-up of 42.4 months. IR was reported for 7288 shoulders (94%). Measurement systems were highly heterogeneous necessitating conversion to a common metric. This permitted comparative analysis of 46 studies encompassing 6123 shoulders (79%).

Varus (135°) humeral implant neck shaft angles (NSA) were associated with the greatest post-operative IR, though intermediate (145-147°) and valgus (150-155°) NSA produced comparable results. Varus and intermediate NSA outperformed valgus NSA in terms of mean change in IR.

Accounting for humeral NSA, lateralized glenospheres resulted in greater post-operative IR. When classifying implant systems with the Werthel global offset system, highly lateralized and very highly lateralized systems produced greater post-operative IR than medialized systems.

Conclusion
The results of this systematic review indicate that lateralization of the center-of-rotation and varus humeral NSA optimize IR. A classic Grammont-style rTSA, a medialized center-of-rotation with a valgus NSA, was associated with predictably poor IR. This review suggests trends toward lateralized center of rotation and varus NSA will result in improved IR.


Reverse Total Shoulder Arthroplasty: The Impact of Implant Design on Postoperative Internal Rotation

Risk Factors and Characteristics of Recalcitrant Osteomyelitis Following Appropriate Surgical and Antibiotic Treatment

Introduction: The purpose of this study was to compare osteoarthritis (OA) diagnosis prevalence between isolated anterior cruciate ligament (ACL) reconstruction and ACL reconstruction with meniscus involvement (meniscus repair (MR), partial meniscectomy (APM), both isolated and combined). We hypothesized that meniscus injury in combination with ACL injury would have increased OA prevalence. 
Methods: The PearlDiver Mariner database was used in this study which contains insurance claims information on more than 91 million orthopaedic patients. Five cohorts were identified for this study using Current Procedural Terminology (CPT) codes and included those between the ages of 16 and 60 that underwent isolated ACL reconstruction, isolated MR, ACL+MR, isolated APM, or ACL+APM repair. Groups were matched by patient age, sex, and presence of diagnosis codes for obesity and morbid obesity with each group consisting of 10,125 patients (4685 females and 5440 males). OA prevalence and odds ratio were compared against isolated ACL reconstruction. 
Results: A significantly greater proportion of APM and ACL+APM patients were diagnosed with knee OA within five years of surgery when compared to isolated ACL patients (APM= 735/10,125 (7.3%) and ACL+APM= 459 (4.5%) vs ACL= 338 (3.3%), p=<0.0001 for both comparisons). The odds of knee OA were also greater in APM and ACL+APM patients when compared to isolated ACL patients (Odds Ratio: APM= 2.27 and ACL+APM= 1.38). Patients undergoing isolated MR also demonstrated a slight, yet still statistically significant, increase in OA prevalence and odds within five years of surgery (MR= 396 (3.9%), Odds Ratio= 1.18, p=0.03). Patients undergoing ACL+MR showed a decrease in prevalence of OA when compared to isolated ACL reconstruction (ACL+MR= 254 (2.5%), odds ratio= 0.75, p=0.0005).
Conclusions: Our results support the hypothesis that meniscus injury at arthroscopy significantly increases the risk of developing diagnosed OA within five years. APM, whether isolated or combined with ACL reconstruction, demonstrated the greatest incidence of OA within 5 years when compared to matched groups of patients that underwent ACL reconstruction and/or meniscus repair. These “big data” results confirm previous reports from prospective ACL cohorts, and further support efforts to repair the menisci whenever possible. Interestingly, the lowest incidence of subsequent OA diagnosis was in the group that underwent combined ACL reconstruction and meniscus repair. Future research is needed to better understand the biological and biomechanical mechanisms that contribute to the potentially protective effect of combined ACL reconstruction and meniscus repair.

Save the Meniscus! Incidence of Osteoarthritis Diagnosis Greatest Following Partial Meniscectomy, Either Isolated or in Combination with ACL Reconstruction

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Mortality and Complications in Patients with Chronic Kidney Disease Following Lower Extremity Trauma

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