Italy


Automatic medical image segmentation has wide applications for disease diagnosing. However, it is much more challenging than natural optical image segmentation due to the high-resolution of medical images and the corresponding huge computation cost. The sliding window is a commonly used technique for whole slide image (WSI) segmentation, however, for these methods based on the sliding window, the main drawback is lacking global contextual information for supervision. In this paper, we propose a dual-inputs attention network (denoted as DA-RefineNet) for WSI segmentation, where both local fine-grained information and global coarse information can be efficiently utilized. Sufficient comparative experiments are conducted to evaluate the effectiveness of the proposed method, the results prove that the proposed method can achieve better performance on WSI segmentation compared to methods relying on single-input.

ICPR 2020

DA-RefineNet: Dual-inputs Attention RefineNet for Whole Slide Image Segmentation

medical image analysis

segmentation

deep learning

ICPR 2020 is the premier international conference on Pattern Recognition, gathering leading researchers from around the world to present their latest achievements in Pattern Analysis and Recognition, applied Artificial Intelligence and Machine Learning. The topic of the year is " Putting Artificial intelligence to work on Patterns". 
For the first time, ICPR has employed a two-round review process similar to journal submissions, with new papers allowed to be submitted in either the first or second round and papers submitted in the first round and not accepted allowed to be revised and re-submitted for second round review. 

In this edition of the **ICPR 2020** Conference, there are 1407 Oral/Poster presentations organized in five Tracks: 
- Artificial Intelligence, Machine Learning for Pattern Analysis; 
- Biometrics, Human Analysis and Behavior Understanding; Computer Vision, Robotics and Intelligent Systems; 
- Document and Media Analysis; and 
- Image and Signal Processing. 

The **ICPR 2020** Main Conference program also includes 7 Keynotes from prominent world-renowned scientists, 8 Tutorials, 28 Demos, 8 Challenges, 2 Panels, as well as an Industry/Sponsor Exhibition. In addition, 41 Workshops on a range of important current and emerging research topics complete the ICPR 2020 program. 


poster

With the development of deep convolutional neural networks (CNNs), the object detection accuracy has been greatly improved. But the performance of small object detection is still far from satisfactory, mainly because small objects are so tiny that the information contained in the feature map is limited. Existing methods focus on improving classification accuracy but still suffer from the limitation of bounding box prediction. To solve this issue, we propose a detection framework by generative and discriminative learning. First, a reconstruction generator network is designed to reconstruct the mapping from low frequency to high frequency for anchor box prediction. Then, a detector module extracts the regions of interest (ROIs) from generated results and implements a RoI-Head to predict object category and refine bounding box. In order to guide the reconstructed image related to the corresponding one, a discriminator module is adopted to tell from the generated result and the original image. Extensive evaluations on the challenging MS-COCO dataset demonstrate that our model outperforms most state-of-the-art models in detecting small objects, especially the reconstruction module improves the average precision for small object (APs) by 7.7%.

Small Object Detection by Generative and Discriminative Learning


The appearance of tumor cell clusters in pleural effusion is usually a vital sign of cancer metastasis. Segmentation, as an indispensable basis, is of crucial importance for diagnosing, chemical treatment, and prognosis in patients. However, accurate segmentation of unstained cell clusters containing more detailed features than the fluorescent staining images remains to be a challenging problem due to the complex background and unclear boundary.

Fused 3-Stage Image Segmentation for Pleural Effusion Cell Clusters

Generative adversarial nets (GANs) have been successfully applied in many fields like image generation, inpainting, super-resolution, and drug discovery, etc. By now, the inner process of GANs is far from being understood. To get a deeper insight into the intrinsic mechanism of GANs, in this paper, a method for interpreting the latent
space of GANs by analyzing the correlation between latent variables and the corresponding semantic contents in generated images is proposed. Unlike previous methods that focus on dissecting models via feature visualization, the emphasis of this work is put on the variables in latent space, i.e. how the latent variables affect the quantitative analysis of generated results. Given a pre-trained GAN model with weights fixed, the latent variables are intervened to analyze their effect on the semantic content in generated images. A set of controlling latent variables can be derived for specific content generation, and the controllable semantic content manipulation is achieved. The proposed method is testified on the datasets Fashion-MNIST and UT Zappos50K, experiment results show its effectiveness

Interpreting the Latent Space of GANs via Correlation Analysis for Controllable Concept Manipulation 



Fast and accurate landmark location and bounding box detection are important steps in 3D medical imaging. In this paper, we propose a novel multi-task learning framework, for real-time, simultaneous landmark location and bounding box detection in 3D space. Our method extends the famous singleshot multibox detector (SSD) from single-task learning to multitask learning and from 2D to 3D. Furthermore, we propose a post-processing approach to refine the network landmark output, by averaging the candidate landmarks. Owing to these settings, the proposed framework is fast and accurate. For 3D cardiac magnetic resonance (MR) images with size 224 × 224 × 64, our framework runs 128 volumes per second (VPS) on GPU and achieves 6.75mm average point-to-point distance error for landmark location, which outperforms both state-of-the-art and baseline methods. We also show that segmenting the 3D image cropped with the bounding box results in both improved performance and efficiency.

One-stage Multi-task Detector for 3D Cardiac MR Imaging

Crowd counting plays an increasingly important role in public security. Recently, many crowd counting methods for a single image have been proposed but few studies have focused on using temporal information from image sequences of videos to improve prediction performance. In the existing methods using videos for crowd estimation, temporal features and spatial features are modeled jointly for the prediction, which makes the model less efficient in extracting spatiotemporal features and difficult to improve the performance of predictions. In order to solve these problems, this paper proposes a Parasite-Host Network (PHNet) which is composed of Parasite branch and Host branch to extract temporal features and spatial features respectively. To specifically extract the transform features in the time domain, we propose a novel architecture termed as “Relational Extractor”(RE) which models the multiplicative interaction features of adjacent frames. In addition, the Host branch extracts the spatial features from a current frame which can be replaced with any model that uses a single image for the prediction. We conducted experiments by using our PHNet on four video crowd counting benchmarks: Venice,UCSD,FDST and CrowdFlow. Experimental results show that PHNet achieves superior performance on these four datasets to the state-of-the- art methods.

PHNet: Parasite-Host Network for Video Crowd Counting

We consider the problem of object segmentation in cultural sites. Since collecting and labeling large datasets of real images is challenging, we investigate whether the use of synthetic images can be useful to achieve good segmentation performance on real data. To perform the study, we collected a new dataset comprising both real and synthetic images of 24 artworks in a cultural site. The synthetic images have been automatically generated from the 3D model of the considered cultural site using a tool developed for that purpose. Real and synthetic images have been labeled for the task of semantic segmentation of artworks. We compare three different approaches to perform object segmentation exploiting real and synthetic data. The experimental results point out that the use of synthetic data helps to improve the performances of segmentation algorithms when tested on real images. Satisfactory performance is achieved exploiting semantic segmentation together with image-to-image translation and including a small amount of real data during training. To encourage research on the topic, we publicly release the proposed dataset at the following url: https://iplab.dmi.unict.it/EGO-CH-OBJ-SEG/

Semantic Object Segmentation in Cultural Sites using Real and Synthetic Data

With the prosperous development of Convolutional Neural Networks, currently they can perform excellently on visual understanding tasks when the input images are high quality and common quality images. However, large degradation in performance always occur when the input images are low quality images. In this paper, we propose a new super-resolution method in order to improve the classification performance for low-resolution images. In an image, the regions in which pixel values vary dramatically contain more abundant high frequency contents compared to other parts. Based on this fact, we design a weight map and integrate it with a super-resolution CNN training framework. During the process of training, this weight map can find out positions of the high frequency pixels in ground truth high-resolution images. After that, the pixel-level loss function takes effect only at these found positions to minimize the difference between reconstructed high-resolution images and ground truth high-resolution images. Compared with other state-of-the-art super-resolution methods, the experiment results show that our method can recover more high frequency contents in high-resolution image reconstructing, and better improve the classification accuracy after low-resolution image preprocessing.

Improving Low-Resolution Image Classification by Super-Resolution with Enhancing High-Frequency Content

Modern convolutional networks such as ResNet and NASNet have achieved state-of-the-art results in many computer vision applications. These architectures consist of stages, which are sets of layers that operate on representations in the same resolution. It has been demonstrated that increasing the number of layers in each stage improves the prediction ability of the network. However, the resulting architecture becomes computationally expensive in terms of floating point operations, memory requirements and inference time. Thus, significant human effort is necessary to evaluate different trade-offs between depth and performance. To handle this problem, recent works have proposed to automatically design high-performance architectures, mainly by means of neural architecture search (NAS). Current NAS strategies analyze a large set of possible candidate architectures and, hence, require vast computational resources and take many GPUs days. Motivated by this, we propose a NAS approach to efficiently design accurate and low-cost convolutional architectures and demonstrate that an efficient strategy for designing these architectures is to learn the depth stage-by-stage. For this purpose, our approach increases depth incrementally in each stage taking into account its importance, such that stages with low importance are kept shallow while stages with high importance become deeper. We conduct experiments on the CIFAR and different versions of ImageNet datasets, where we show that architectures discovered by our approach achieve better accuracy and efficiency than human-designed architectures. Additionally, we show that architectures discovered on CIFAR-10 can be successfully transferred to large datasets. Compared to previous NAS approaches, our method is substantially more efficient, as it evaluates one order of magnitude fewer models and yields architectures on par with the state-of-the-art.

Stage-Wise Neural Architecture Search

Since gaze estimation plays a crucial role in recognizing human intentions, it has been researched for a long time, and its accuracy is ever increasing. However, due to the wide variation in eye shapes and focusing abilities between the individuals, accuracies of most algorithms vary depending on each person in the test group, especially when the initial calibration is not well performed. To alleviate the user-dependency, we attempt to derive features that are general for most people and use them as the input to a deep network instead of using the images as the input. Specifically, we use the pupil shape as the core feature because it is directly related to the 3D eyeball rotation, and thus the gaze direction. While existing deep learning
methods learn the gaze point by extracting various features from the image, we focus on the mapping function from the eyeball rotation to the gaze point by using the pupil shape as the input. It is shown that the accuracy of gaze point estimation also becomes robust for the uncalibrated points by following the characteristics of the mapping function. Also, our gaze network learns the gaze difference to facilitate the re-calibration process to fix the calibration-drift problem that typically occurs with glass-type or head-mount devices.


User-Independent Gaze Estimation by Extracting Pupil Parameter and Its Mapping to the Gaze Angle

Activation in deep neural networks is fundamental to achieving non-linear mappings. Traditional studies mainly focus on finding fixed activations for a particular set of learning tasks or model architectures. The research on flexible activation is quite limited in both designing philosophy and application scenarios. In this study, three principles of choosing flexible activation components are proposed and a general combined form of flexible activation functions is implemented. Based on this, a novel family of flexible activation functions that can replace sigmoid or tanh in LSTM cells are implemented, as well as a new family by combining ReLU and ELUs. Also, two new regularisation terms based on assumptions as prior knowledge are introduced. It has been shown that LSTM models with proposed flexible activations P-Sig-Ramp provide significant improvements in time series forecasting, while the proposed P-E2-ReLU achieves better and more stable performance on lossy image compression tasks with convolutional auto-encoders. In addition, the proposed regularization terms improve the convergence, performance and stability of the models with flexible activation functions.

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DA-RefineNet: Dual-inputs Attention RefineNet for Whole Slide Image Segmentation

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