François Berger Brain Tech Lab director Neurologist and Professor of cell Biology in Grenoble medical university fberger@univ-grenoble-alpes.fr

INSERM U1205 UFR CHIMIE-BIOLOGIE Bât. B - 3ème étage 2280 rue de la piscine 38400 Saint-Martin-d'Hères Tél. : + 33 04.56.52.03.73 – Mobile : + 33 782462026

EDUCATION/TRAINING

• 1980 Medical studies at Poitiers University-France.
• 1985 Neurology residency - (Angers university hospital
• 1995: Immunology certificate, (Poitiers University, Pr. Prudhomme- France).
• 1986 General histology certificate, (Cochin University, Pr. Schram-France).
• 1988 Master of molecular and cellular biology (Rennes University-France) supported by a “research year” grant.
• 1990 Validation of Neurology Residency and MD graduation
• 1991 PhD, in biology, October 27, 1995.
• 1995-1997 Post-doctoral Fellowship (Fred Gage laboratory of genetic, Salk Institute, San Diego USA)
• Sept. 1997 “Habilitation for research direction” Grenoble University-France

PROFESSIONAL CAREER 2016: Director of the new INSERM research unit U1205 in Grenoble hospital. 2011-2014: director of Clinatec Lab INSERM UA 01 and CLINATEC INSTITUTE, CEA, Grenoble (Grenoble (Innovative Applications of Micro-Nano-Technologies to Medicine). Since 2009: scientific advisor of the French technology Institute associating all the public research agencies in France (CEA, INSERM, CNRS, INRIA) Since 2004: Head of the INSERM research laboratory “Brain nanomedicine group” Since 2000: Professor of Cell Biology and Oncology- clinical activity in the field of neuro-oncology 1999-2004: Head of the neuro-oncology group in the INSERM research laboratory of AL Benabid. 1994- 1995 Assistant in cell biology and neuro-oncology

INSTITUTIONAL RESPONSIBILITIES

• Since 2012: Scientific advisor of OMNT (observatoire des micro-nano-technologies)
• Since 2009: Scientific advisor of the French technology Institute associating all the public research agencies in France (CEA, INSERM, CNRS, INRIA)- Paris-France
• 2007-2012: National Scientific advisor of the “Ligue Nationale contre le cancer” (first cancer association in France)- Paris-France
• Since 2015: Scientific advisor of the French NCI- Paris-France

HONORS AND AWARDS

• 1989: Residency gold Medal.
• 1995: Michel Clavel Prize
• 2015: Biovision Prize for innovation

PERSONAL STATEMENT During the last 10 years, my carrier was focused to the implementation of a translational research in the field of neurotechnologies. Our lab is a unique translational technology lab associating neurosurgeons, biologists, and technologists in the context of BrainTech innovation and first in man proof of concept. In the continuation of the pioneering neurostimulation research done in Grenoble, we developed an innovative “BrainPrint” technology that give access to inaccessible brain territories in a spatial and molecular-investigations compatible way. This BrainPrint technology involves micro-nano-chemically modified silicon. This technology is unique, patented at the international level and was validated this year in a proof of concept trial in human glioblastoma supported by the “French-NCI” (INCA). An European grant was obtained to move this in the field of neurodegenerative diseases using a second-generation device (Eranet Brainomics). This delineate a new biomedical procedure to explore inaccessible territories paving the way for precision medicine and targeted therapies in neurodegenerative diseases and to renovate targeted therapies in oncology. Beside and in synergy with this innovative technology that is now validated, we develop innovative therapeutic strategies involving local delivery and physical modulation of the brain microenvironment. Coordinator of several medtech trial. Research area: neuro-oncology, neurosciences, biomarkers, nanomedicine