Background
Anatomic Total Shoulder Arthroplasty (ATSA) and Reverse Total Shoulder Arthroplasty (RTSA) reliably alleviate pain and restore shoulder function for a variety of indications. However, these procedures are not well-studied in patients with neurocognitive impairment. Therefore, the purpose of this study was to investigate whether patients with dementia or mild cognitive impairment (MCI) have increased odds of surgical or medical complications following arthroplasty.

Methods
The PearlDiver database was queried from April 2010 through October 2021 to identify a cohort of patients who underwent either ATSA or RTSA and had a minimum 2-year follow-up. Current Procedural Terminology (CPT) and International Classification of Diseases (ICD) codes were used to stratify this cohort into three groups: (1) patients with dementia, (2) patients with MCI, and (3) patients with neither condition. Surgical and medical complication rates were compared among these three groups.

Results
The overall prevalence of neurocognitive impairment among patients undergoing TSA was 3.0% in a cohort of 92,022 patients. Patients with dementia had increased odds of sustaining a periprosthetic humerus fracture (OR = 1.46, p <0.001), developing prosthesis instability (OR = 1.72, p < 0.001), and undergoing revision arthroplasty (OR = 1.55, p = 0.003) after RTSA compared to patients with normal cognition. ATSA patients with dementia did not have an elevated risk of surgical complications or revision. Conversely, RTSA patients with MCI did not have an elevated risk of complications or revision, although ATSA patients with MCI had greater odds of prosthesis instability (OR = 2.51, p = 0.008). Additionally, patients with neurocognitive impairment had elevated odds of medical complications compared to patients with normal cognition, including acute myocardial infarction and cerebrovascular accident.

Conclusion
Compared to patients with normal cognition, RTSA patients with pre-operative dementia and ATSA patients with pre-operative MCI are at increased risk for surgical complications. Moreover, both ATSA and RTSA patients with either pre-operative MCI or dementia are at increased risk for medical complications. As the mean age in the U.S. continues to rise, special attention should be directed towards patients with neurocognitive impairment to minimize post-operative complications after TSA.

Total Shoulder Arthroplasty in Patients with Dementia or Mild Cognitive Impairment

 Orthopaedic Surgery

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