Emerging Medical Treatments for Pediatric Cerebrovascular Disease

**Abstract authors:**

Claire Champigny¹, Samantha Feldman¹, Nataly Beribisky², Mary Desrocher², Tamiko Isaacs², Pradeep Krishnan¹, Georges Monette², Nomazulu Dlamini¹, Peter Dirks¹, Robyn Westmacott¹

¹the Hospital for Sick Children, ²York University

**Abstract body:**

Objective: This prospective clinical study examined the impact of eight predictors on neurocognitive outcomes following pediatric stroke across a range of domains (e.g., processing speed, working memory, executive functions). Predictors included: age at stroke, stroke type (arterial ischemic vs. hemorrhagic), lesion size relative to total brain volume, lesion location and structures involved, time since stroke, neurologic severity, presence of seizure disorder post-stroke, and socioeconomic status (i.e., household income). Method: Youth with a history of stroke (n=92) underwent neuropsychological testing. Their caregivers completed a standardized parent report. Hospital records provided medical history. Spline regressions, likelihood ratio tests, one-way analysis of variance, Welch's t-tests, and simple linear regressions examined associations between predictors and outcome measures. Results: Larger lesions and lower household income were significantly associated with worse neurocognitive outcomes across most domains. Ischemic stroke was associated with worse outcome in attention and executive functions compared to hemorrhagic stroke. Participants with a seizure disorder had more severe executive functioning impairments than participants without seizures. Youth with cortical-subcortical lesions scored lower on a few measures than youth with cortical or subcortical lesions. Neurologic severity predicted scores on few measures. No significant differences were found based on age at stroke, time since stroke, lesion laterality, or supra- versus infratentorial lesion. Conclusions: Lesion size and household income predict neurocognitive outcome following pediatric stroke. Findings should inform clinical practice through enhanced appraisals of prognosis, tailored psychoeducation for families, and the development of services and interventions aimed at fostering optimal development for youth with stroke.

Lesion size and household income predict neurocognitive outcome following pediatric stroke

**Moderators:** [Laura Lehman, MD, MPH](https://underline.io/speakers/120438-laura-lehman) | Neurology | Boston, United States and [Lisa Sun, MD](https://underline.io/speakers/119758-lisa-sun) | Neurology | Baltimore, United States

Speaker Session: Emerging Medical Treatments for Pediatric Cerebrovascular Disease

panel

Dear IPSO Virtual Conference Attendees:

Welcome to the IPSO 2023 Virtual Conference. We are delighted to bring together experts from multiple disciplines and six continents to provide a diverse perspective on pediatric cerebrovascular disease.

A few quick words about what to expect. Two important goals of this conference are to (1) foster a sense of community and (2) identify global priorities for our field. We encourage you to express your thoughts live in through the chat function to provide a global perspective on all topics. Please introduce yourself in the chat, so everyone knows where you are attending from.

We are excited to announce IPSO is able to offer 9.5 CME units for the virtual conference. If you would like to claim CME credits, please email membership@internationalpediatricstroke.org. 

We want to hear from you! Planning for IPSO 2024 Congress on March 22nd-24th in Toronto, Canada, will commence as soon as the Virtual Conference ends. Let us know your priorities through the live chat function, via email, or by submitting a symposium idea. Based on your input, the Scientific Program Committee will select the topics that we will address in greater depth when we meet again in the spring.

We hope you find the Virtual Conference both interesting and educational, and hope to see you in person in Toronto, or at another IPSO meeting in the future.

Warm regards,

Heather Fullerton, IPSO President 
Maja Steinlin, IPSO Vice-President 
Lori Jordan, IPSO Secretary & Treasurer 
Noma Dlamini, IPSO Scientific Program Committee Chair 


The International Pediatric Stroke Organization (IPSO) 2023 Virtual Conference is April 28-29th, 2023. The mission of the virtual conference is to unify the global community of professionals engaged in research and clinical care for children with cerebrovascular diseases, and chart a path forward for multinational, multidisciplinary efforts. Similar to the IPSO 2021 Virtual Conference, IPSO has partnered with Underline to host this virtual conference. 

The 2023 IPSO Virtual Conference will offer:

* A highly interactive format: brief recorded talks followed by live panel discussions with audience participation through a chat function and live audience surveys
* Optional break-out groups for IPSO committees, working groups, councils
* Poster sessions available on-demand throughout the conference with a chat function for the audience to comment for ask questions of the presenters

Disclaimer: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of UCSF and the International Pediatric Stroke Organization (IPSO) and Hospital for Sick Children, and Vanderbilt University Medical Center. UCSF is accredited by the ACCME to provide continuing medical education for physicians.

 UCSF designates this live activity for a maximum of 9.5 AMA PRA Category 1 credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Contact membership@internationalpediatricstroke.org if you would like to claim CME for the IPSO 2023 Virtual Conference. 

**About** 
Founded in February, 2019, we are an organization of health professionals, scientists and patient advocates who care about stroke and other cerebrovascular diseases in childhood. We developed out of our original collaborative network, the International Pediatric Stroke Study (IPSS), and now aim to broaden the scope of our mission beyond research.

* Our mission is to improve the lives of children worldwide with cerebrovascular disease through research, education, clinical care and advocacy.

* Our Vision is a world in which international, multidisciplinary collaborations advance the understanding, care, and outcomes of childhood cerebrovascular disease.

To access IPSO 2023 site, please register [here](https://internationalpediatricstroke.org/2023-virtual-conference/registration/). 

IPSO 2023

The mission of the International Pediatric Stroke Organization (IPSO) 2023 Virtual Conference is to unify the global community of professionals engaged in research and clinical care for children with cerebrovascular diseases, and chart a path forward for multinational, multidisciplinary efforts. 



On demand posters are available for viewing at your leisure. 
*Click the purple 'View Posters' button to the right of this screen to scroll through all posters*

Posters A: Acute Treatment 
Posters B: Ischemic Stroke 
Posters C: Moyamoya 
Posters D: Outcomes and Rehabilitation 
Posters E: Perinatal Stroke 
Posters F: Risk Factors and Prevention 
Posters G: Stroke Readiness and Guidelines 
Posters H: Vascular Malformations and Hemorrhagic Stroke 

**Poster Abstract Proceedings** **can be downloaded** **[here](https://drive.google.com/file/d/14SWqMGjC8LaaNqTHR5qKPPDOW4AMtsOY/view?usp=sharing)**.

Peter Dirks

2

2

Presentations

Emerging Medical Treatments for Pediatric Cerebrovascular Disease

Lesion size and household income predict neurocognitive outcome following pediatric stroke

Stay up to date with the latest Underline news!

PRESENTATIONS

CONFERENCES

COMPANY

RESOURCES