Adverse drug-drug interactions (DDIs) can compromise the effectiveness of concurrent drug administration, 
posing a significant challenge in healthcare. 
As the development of new drugs continues, 
the potential for unknown adverse effects resulting from DDIs becomes a growing concern. 
Traditional computational methods for DDI prediction 
may fail to capture interactions for new drugs
due to the lack of knowledge.
In this paper,
we introduce a new problem setup as zero-shot DDI prediction
that deals with the case of new drugs.
Leveraging textual information from online databases like DrugBank and PubChem, 
we propose an innovative approach TextDDI
with a language model-based DDI predictor
and a reinforcement learning~(RL)-based information selector,
enabling the selection of concise and pertinent text for accurate DDI prediction on new drugs.
Empirical results show the benefits of the proposed approach
on several settings including zero-shot and few-shot DDI prediction,
and the selected texts are semantically relevant. Our code and data are available at https://github.com/zhufq00/DDIs-Prediction.

Learning to Describe for Predicting Zero-shot Drug-Drug Interactions

Event skeleton generation, aiming to induce an event schema skeleton graph with abstracted event nodes and their temporal relations from a set of event instance graphs, is a critical step in the temporal complex event schema induction task. Existing methods effectively address this task from a graph generation perspective but suffer from noise-sensitive and error accumulation, e.g., the inability to correct errors while generating schema. We, therefore, propose a novel Diffusion Event Graph Model~(DEGM) to address these issues. Our DEGM is the first workable diffusion model for event skeleton generation, where the embedding and rounding techniques with a custom edge-based loss are introduced to transform a discrete event graph into learnable latent representations. Furthermore, we propose a denoising training process to maintain the model's robustness. Consequently, DEGM derives the final schema, where error correction is guaranteed by iteratively refining the latent representations during the schema generation process. Experimental results on three IED bombing datasets demonstrate that our DEGM achieves better results than other state-of-the-art baselines. Our code and data are available at https://github.com/zhufq00/EventSkeletonGeneration.

<iframe src="https://app.sli.do/event/iHwnn5G9xYwcAmSbeKA4Au/embed/polls/e4feefab-5994-4fe6-9f80-b5af3684a637" width="300" height="400"></iframe>

A Diffusion Model for Event Skeleton Generation

Script event prediction aims to predict the subsequent event given the context. This requires the capability to infer the correlations between events. Recent works have attempted to improve event correlation reasoning by using pretrained language models and incorporating external knowledge~(e.g., discourse relations). Though promising results have been achieved, some challenges still remain. First, the pretrained language models adopted by current works ignore event-level knowledge, resulting in an inability to capture the correlations between events well. Second, modeling correlations between events with discourse relations is limited because it can only capture explicit correlations between events with discourse markers, and cannot capture many implicit correlations. To this end, we propose a novel generative approach for this task, in which a pretrained language model is fine-tuned with an event-centric pretraining objective and predicts the next event within a generative paradigm. Specifically, we first introduce a novel event-level blank infilling strategy as the learning objective to inject event-level knowledge into the pretrained language model, and then design a likelihood-based contrastive loss for fine-tuning the generative model. Instead of using an additional prediction layer, we perform prediction by using sequence likelihoods generated by the generative model. Our approach models correlations between events in a soft way without any external knowledge. The likelihood-based prediction eliminates the need to use additional networks to make predictions and is somewhat interpretable since it scores each word in the event. Experimental results on the multi-choice narrative cloze~(MCNC) task demonstrate that our approach achieves better results than other state-of-the-art baselines. Our code will be available at \url{https://github.com/zhufq00/mcnc}.

A Generative Approach for Script Event Prediction via Contrastive Fine-tuning

Information Retrieval and Text Mining

technical paper

**Welcome to EMNLP 2023!**

On behalf of the EMNLP 2023 Organizing Committee, I extend a warm and heartfelt welcome to all of you to the 2023 Conference on Empirical Methods in Natural Language Processing (EMNLP). It is with immense pleasure and excitement that we gather here in Singapore, a vibrant hub of innovation and technological advancement.

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Virtual Poster Session 1

poster

### Welcome to ACL 2023, the 61st Annual Meeting of the Association for Computational Linguistics! 
 The conference will be held in Toronto, Canada, July 9-14, 2023. 
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SNLP: Applications 2

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-23 is the Thirty-Seventh AAAI Conference on Artificial Intelligence. The theme of this conference is to create collaborative bridges within and beyond AI. Like previous AAAI conferences, AAAI-23 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and two new activities: a Bridge Program and a Lab Program. Many of these activities are tailored to the theme of bridges and all are selected according to the highest standards, with additional programs for students and young researchers. 
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AAAI 2023

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines.

Fangqi Zhu

3

SHORT BIO

Presentations

Learning to Describe for Predicting Zero-shot Drug-Drug Interactions

A Diffusion Model for Event Skeleton Generation

A Generative Approach for Script Event Prediction via Contrastive Fine-tuning

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