Diabetic retinopathy (DR), with its large patient population, has become a formidable threat to human visual health. In the clinical diagnosis of DR, multi-view fundus images are considered to be more suitable for DR diagnosis because of the wide coverage of the field of view. Therefore, different from most of the previous single-view DR grading methods, we design a dynamic selection-driven multi-view DR grading method to fit clinical scenarios better. Since lesion information plays a key role in DR diagnosis, previous methods usually boost the model performance by enhancing the lesion feature. However, during the actual diagnosis, ophthalmologists not only focus on the crucial parts, but also exclude irrelevant features to ensure that do not compromise the accuracy of their judgment. To this end, we introduce the idea of dynamic selection and design a series of selection mechanisms from fine granularity to coarse granularity. In this work, we first introduce an Ophthalmic Image Reader (OIR) agent to provide the model with pixel-level prompts of suspected lesion areas. Moreover, a Multi-View Token Selection Module (MVTSM) is designed to prune redundant feature tokens and realize dynamic selection of key information. In the final decision stage, we dynamically fuse multi-view features through the novel Multi-View Mixture of Experts Module (MVMoEM), to enhance key views and reduce the impact of conflicting views. Extensive experiments on a large multi-view fundus image dataset with 34,452 images demonstrate that our method performs favorably against state-of-the-art models. The public code can be available in the attachment.

Like an Ophthalmologist: Dynamic Selection Driven Multi-View Learning for Diabetic Retinopathy Grading

As we all know, multi-view data is more expressive than single-view data and multi-label annotation enjoys richer supervision information than single-label, which makes multi-view multi-label learning widely applicable for various pattern recognition tasks. In this complex representation learning problem, three main challenges can be characterized as follows: i) How to learn consistent representations of samples across all views? ii) How to exploit and utilize category correlations of multi-label to guide inference? iii) How to avoid the negative impact resulting from the incompleteness of views or labels? To cope with these problems, we propose a general multi-view multi-label learning framework named label-guided masked view- and category-aware transformers in this paper. First, we design two transformer-style based modules for cross-view features aggregation and multi-label classification, respectively. The former aggregates information from different views in the process of extracting view-specific features, and the latter learns subcategory embedding to improve classification performance. Second, considering the imbalance of expressive power among views, an adaptively weighted view fusion module is proposed to obtain view-consistent embedding features. Third, we impose a label manifold constraint in sample-level representation learning to maximize the utilization of supervised information. Last but not least, all the modules are designed under the premise of incomplete views and labels, which makes our method adaptable to arbitrary multi-view and multi-label data. Extensive experiments on five datasets confirm that our method has clear advantages over other state-of-the-art methods.

Incomplete Multi-View Multi-Label Learning via Label-Guided Masked View- and Category-Aware Transformers

In recent years, multi-view multi-label learning has aroused extensive research enthusiasm. However, multi-view multi-label data in the real world is commonly incomplete due to the uncertain factors of data collection and manual annotation, which means that not only multi-view features are often missing, and label completeness is also difficult to be satisfied. To deal with the double incomplete multi-view multi-label classification problem, we propose a deep instance-level contrastive network, namely DICNet. Different from conventional methods, our DICNet focuses on leveraging deep neural network to exploit the high-level semantic representations of samples rather than shallow-level features. First, we utilize the stacked autoencoders to build an end-to-end multi-view feature extraction framework to learn the view-specific representations of samples. Furthermore, in order to improve the consensus representation ability, we introduce an incomplete instance-level contrastive learning scheme to guide the encoders to better extract the consensus information of multiple views and use a multi-view weighted fusion module to enhance the discrimination of semantic features. Overall, our DICNet is adept in capturing consistent discriminative representations of multi-view multi-label data and avoiding the negative effects of missing views and missing labels. Extensive experiments performed on five datasets validate that our method outperforms other state-of-the-art methods.

DICNet: Deep Instance-Level Contrastive Network for Double Incomplete Multi-View Multi-Label Classification

Diabetic retinopathy (DR) is the main cause of irreversible blindness for working-age adults. The previous models for DR detection have difficulties in clinical application. The main reason is that most of the previous methods only use single-view data, and the single field of view (FOV) only accounts for about 13% of the FOV of the retina, resulting in the loss of most lesion features. To alleviate this problem, we propose a multi-view model for DR detection, which takes full advantage of multi-view images covering almost all of the retinal field. To be specific, we design a Cross-Interaction Self-Attention based Module (CISAM) that interfuses local features extracted from convolutional blocks with long-range global features learned from transformer blocks. Furthermore, considering the pathological association in different views, we use the feature jigsaw to assemble and learn the features of multiple views. Extensive experiments on the latest public multi-view MFIDDR dataset with 34,452 images demonstrate the superiority of our method, which performs favorably against state-of-the-art models. To the best of our knowledge, this work is the first study on the public large-scale multi-view fundus images dataset for DR detection. The code of our paper is available at github.com/XiaolingLuo/MVCINN.

MVCINN: Multi-View Diabetic Retinopathy Detection Using a Deep Cross-Interaction Neural Network

As a combination of emerging multi-view learning methods and traditional multi-label classification tasks, multi-view multi-label classification has shown broad application prospects. The diverse semantic information contained in heterogeneous data effectively enables the further development of multi-label classification. However, the widespread incompleteness problem on multi-view features and labels greatly hinders the practical application of multi-view multi-label classification. Therefore, in this paper, we propose an attention-induced missing instances imputation technique to enhance the generalization ability of the model. Different from existing incomplete multi-view completion methods, we attempt to approximate the latent features of missing instances in embedding space according to cross-view joint attention, instead of recovering missing views in kernel space or original feature space. Accordingly, multi-view completed features are dynamically weighted by the confidence derived from joint attention in the late fusion phase. In addition, we propose a multi-view multi-label classification framework based on label-semantic feature learning, utilizing the statistical weak label correlation matrix and graph attention network to guide the learning process of label-specific features. Finally, our model is compatible with missing multi-view and partial multi-label data simultaneously and extensive experiments on five datasets confirm the advancement and effectiveness of our embedding imputation method and multi-view multi-label classification model.

Attention-Induced Embedding Imputation for Incomplete Multi-View Partial Multi-Label Classification

Diabetic Retinopathy (DR), the leading cause of blindness in diabetic patients, is diagnosed by the condition of retinal multiple lesions. As a difficult task in medical image segmentation, DR multi-lesion segmentation faces the main concerns as follows. On the one hand, retinal lesions vary in location, shape, and size. On the other hand, because some lesions occupy only a very small part of the entire fundus image, the high proportion of background leads to difficulties in lesion segmentation. To solve the above problems, we propose a heterogeneous-aware convolutional network (HACDR-Net) that composes heterogeneous cross-convolution, heterogeneous modulated deformable convolution, and optional near-far-aware convolution. Our network introduces an adaptive aggregation module to summarize the heterogeneous feature maps and get diverse lesion areas in the heterogeneous receptive field along the channels and space. In addition, to solve the problem of the highly imbalanced proportion of focal areas, we design a new medical image segmentation loss function, Noise Adjusted Loss (NALoss). NALoss balances the predictive feature distribution of background and lesion by jointing Gaussian noise and hard example mining, thus enhancing awareness of lesions. We conduct the experiments on the public datasets IDRiD and DDR, and the experimental results show that the proposed method achieves better performance than other state-of-the-art methods. The code is open-sourced on github.com/xqh180110910537/HACDR-Net.

Xiaoling Luo

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