With 10 million deaths in 2020 cancer remains one of the most challenging diseases in contemporary medicine. Chemotherapy, surgery, and radiation therapy are commonly used to treat cancer. These treatments severely harm healthy tissues and succeed rarely in advance stages of disease. Recent studies indicate that magnetic hyperthermia, which involves targeted delivery of magnetic nanoparticles to tumor cells followed by localised remote heating of cancer tissues could revolutionise clinical practice in the treatment of cancer, either as standalone intervention or adjunct to radiotherapy and chemotherapy. Water dispersible magnetic nanoparticles (MNPs) of ferrites (AFe2O4; A=Fe, Mn, Co) are the promising candidates for magnetic hyperthermia due to their high chemical stability, biocompatibility, moderate magnetization and high specific absorption rates (SAR). In this article, we have evaluated magnetic hyperthermia efficiency of water based magnetic fluids of AFe2O4 nanoparticles. AFe2O4 nanoparticles were synthesized by chemical co-precipitation method. Nanoparticles were coated with a bilayer of oleic acid and dispersed in water. MNPs concentrations in magnetic fluids were 70 mg/mL for Fe3O4, 200 mg/mL for MnFe2O4 and 60 mg/mL for CoFe2O4. Structural and magnetic properties of MNPs were investigated by X-Ray diffraction (XRD) and vibrating sample magnetometer (VSM), respectively. XRD study revealed that AFe2O4 NPs exhibits cubic inverse spinel structure. Fe3O4 (Ms = 48 emu/g, Mr = 2.60 emu/g, Hc = 49 Oe), MnFe2O4 (Ms = 40 emu/g, Mr = 2.60 emu/g, Hc = 35 Oe) and CoFe2O4 (44 emu/g, Mr = 10.10 emu/g, Hc =440 Oe) NPs exhibits soft ferromagnetic behaviour. Magnetic hyperthermia measurements were performed as a function of magnetic field strength (2-10 mT) and field frequency (162-935.6 kHz) for 10 minutes. MNPs exhibits highest SAR values for 10 mT field strength at 935.6 kHz. Amongst the tested MNPs, Fe3O4 has the highest SAR value (27.35 W/g), followed by MnFe2O4 (1.91 W/g) and CoFe2O4 (0.94 W/g). Considering this, it is concluded that amongst the inverse spinel ferrite nanostructures AFe2O4 (A=Fe, Mn, Co), Fe3O4 nanoparticles are most suitable for magnetic fluid hyperthermia applications. 
**References:** 

![](https://s3.eu-west-1.amazonaws.com/underline.prod/uploads/markdown_image/1/image/2d6c777cb29f24ca3bc493ac8517b198.png)

Magnetic Hyperthermia of AFe2O4 (A=Fe, Mn, Co) Nanoparticles Prepared by Co precipitation Method.

Polycrystalline lanthanum strontium manganese oxide (LSMO), La1-xSrxMnO3 (x = 0.1–0.4) nanoparticles (NPs) exhibit interesting size dependent structural and magnetic. They find interesting applications in catalysis, biomedicine and data storage [1]. LSMO NPs have attracted considerable attention in recent years because of their tunable novel magnetic properties [2], single domain superparamagnetic structure with near room temperature Curie point (Tc) [3]. Properties of LSMO NPs are strongly correlated with the extent of Sr-doping at La site, their particle size and extent to which different crystallographic phases (rhombohedral / orthorhombic) present. The aim of this study is to understand the effect of Sr-doping on structural and magnetic properties of LSMO NPs synthesized via sol-gel auto combustion route. Their structural and magnetic properties were investigated by X-Ray diffraction coupled with Rietveld refinement and vibrating sample magnetometer. The Rietveld refinement of diffractograms revealed that irrespective of Sr-doping, LSMO NPs were crystallized in rhombohedral (R-3c) and orthorhombic (Pbnm) mixed phases. The rhombohedral phase appears to be the dominant crystalline phase. VSM of Sr-doping LSMO NPs exhibits single domain superparamagnetic structure. With the decrease in Sr-doping, the saturation magnetization (Ms) of LSMO NPs also decreases (Fig. 1), while their Tc remained constant at 360 + 10 K. In order to establish the correlation between the structural and magnetic properties of LSMO NPs, M-H curves were fitted with the modified Langevin function [4, 5]. From the best fits, Ms, dm (magnetic particle size) and s (polydispersity index) were determined. It was observed that with decrease in Sr-doping, both dm, and s decreased also resulting in reduction in their Ms. The changes in their magnetic properties are in good correlation with the relative changes in the rhombohedral and orthorhombic phases. Thus, through Sr-doping, magnetic properties of LSMO NPs can be tuned by controlling the crystallographic phase fractions.

![](https://assets.underline.io/uploads/markdown_image/1/image/a1b32c80db8f54417e667cf808300c7f.jpg)

Fig. 1 Effect of Sr-doping on the Ms of La1-xSrxMnO3 (x = 0.1 -0.4) nanoparticles

![](https://assets.underline.io/uploads/markdown_image/1/image/0807e7c978d5ad55d841ac4b29bd0d21.jpg)

Fig. 2 Ms–H of La1-xSrxMnO3 (x = 0.1 -0.4) nanoparticles fitted with modified Langevin function

Effect of Sr-doping on Structural and Magnetic Properties of LSMO nanoparticles Prepared by Sol-Gel Auto Combustion Method

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**Session Chair:** Chuanpu Liu, *Colorado State University*

JPB: Ferrites, Garnets and Magneto-Dielectric Materials II

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CPA - Soft Magnetic Materials V: Ferrites and Bulk Crystalline

The 15th Joint MMM-INTERMAG Conference (2022 Joint) is sponsored jointly by AIP Publishing and the IEEE Magnetics Society. Members of the international scientific and engineering communities interested in recent developments in fundamental and applied magnetism are invited to attend and contribute to the technical sessions. The technical program will include invited and contributed papers in oral and poster sessions, invited symposia, a plenary session, and an evening session, with about 1500 presentations overall. This Conference provides an outstanding opportunity for worldwide participants to meet their colleagues and collaborators and discuss developments in all areas of magnetism research.

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Yashpreet Kaur

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Magnetic Hyperthermia of AFe2O4 (A=Fe, Mn, Co) Nanoparticles Prepared by Co precipitation Method.

Effect of Sr-doping on Structural and Magnetic Properties of LSMO nanoparticles Prepared by Sol-Gel Auto Combustion Method

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