Karen Louise Thomsen became a medical doctor in 2002 and obtained her PhD from Aarhus University (AU), Denmark in 2012. She completed her clinical training as a specialist in Hepatology and Gastroenterology in 2016 after having spent a year at the Royal Free Hospital in London. She was appointed assoc. prof. at AU in 2018 and consultant at the Department of Hepatology and Gastroenterology, Aarhus University Hospital in 2019. Also, she has been an honorary assoc. prof. at Institute for Liver and Digestive Health, UCL, UK since 2016. The core theme of her research is studying the pathophysiological impact of inflammation on organ injury in liver disease. Her earlier studies explored the mechanisms regulating urea synthesis in the context of different animal models and in patients. This has been pursued further in fatty liver disease (NASH), in which her group has demonstrated a functional reduction in ureagenesis, that impairs nitrogen homeostasis and results in hyperammonemia. More recently, they have made the novel observation that NASH animals demonstrate cognitive dysfunction. They are now pursuing these observations mechanistically and assessing the broader implications in human NASH.