Microglia activation is a critical component of the post-stroke inflammatory response; however, an accumulation of pro-inflammatory activated microglia can have a detrimental effect and lead to cognitive decline. Strokes that affect the basal ganglia can impair behavioural flexibility, an important component of executive function. An association between activated microglia in the white matter tracts and executive dysfunction has been established but not sufficiently evaluated in the context of stroke. Minocycline is a tetracycline derivative shown to effectively inhibit microglia activation. In this study, we used a rat model to investigate the effects of acute post-stroke minocycline treatment on cognitive outcomes and white matter pathology. Stroke was induced in 8-10-month-old male wildtype Fischer 344 rats by injection of endothelin-1 into the right dorsal striatum. Minocycline was administered for 4 days post-stroke prior to testing for behavioural flexibility, learning and memory using an operant conditioning-based set-shifting task and the Morris water maze. Brains were histologically examined at 28 days post-stroke to assess microglia activation, astrogliosis and infarct size. Results indicate a link between white matter activated microgliosis and behavioural outcomes post-stroke suggesting that modifying microglia activation post-stroke could protect the brain and improve cognitive outcomes.

Targeting post-stroke white matter microgliosis using minocycline to prevent cognitive decline in the rat

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PS-3-C -  Disorders of the Nervous System

poster

Colleagues and Friends:

I am very happy to welcome you to the 14th annual Canadian Neuroscience Meeting, and to the first virtual edition of our meeting. I want to highlight the important work the CAN meeting chair, **Roger Thompson** and co-chair, **Alyson Fournier**, did to put together the great program we are offering this year. Moving to a virtual format required a complete re-design of the program, and both Roger and Alyson did a splendid job in providing us with an appealing and well adapted program for our first virtual event. I wish to thank them for this very important effort.

Highlights of this year’s scientific meeting include invited speakers **Michael Hausser, Franck Polleux, Gwyneth Card, Magdalena Götz**and Brain Prize winner **Huda Zoghbi**. Plenary and parallel symposia, proposed by our members complete our diverse [scientific program.](https://can-acn.org/meeting-2021/program-2021/)

The 2021 Advocacy session, chaired and organized by CAN advocacy committee chair **Karun Singh**, will feature a special lecture and question period with Member of Parliament and past Science Minister **Kirsty Duncan**. This will be followed by a short overview of CAN’s advocacy activities over the last year. We invite you to participate in this session for insight from Dr. Duncan on the workings of Parliament Hill, and to learn more about what CAN has been doing to promote neuroscience research in Canada.

We are also excited to host **Lisa Willis** in the Equity Diversity and Inclusion session, organized by EDI committee chair **Jibran Khokhar**.

A special highlight of our meeting will be the lectures by award-winning young neuroscientists. We are please to host the CAN 2020 Young Investigator Award winner **Mihaela Iordanova**, and CAN 2021 Young Investigator Award winners **Aaron Phillips** and **Tabrez Siddiqui**. Highlights will also include presentation by the top three winners of the CAN-CIHR-INMHA Brain Star Award winners, **Claire Gizowski, Nuria Daviu Abant** and **Lukas Tamayo-Orrego**.

Independently organized satellite symposia complement and complete this exciting program, check them out here: https://can-acn.org/meeting-2021/2021-satellite-symposia/

Some of the most engaging sessions are always the poster sessions featuring the work of our trainees, so make sure to log in to Gather Town during the poster sessions to chat with the presenters.
We hope you enjoy this program, and look forward to welcoming you, virtually.

Shernaz Bamji

President of the Canadian Association for Neuroscience

![](https://assets.underline.io/uploads/markdown_image/1/image/b9aea25343a87d5aac3b9367dc780974.jpg)



Victoria Agapova

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Targeting post-stroke white matter microgliosis using minocycline to prevent cognitive decline in the rat

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