Alzheimer's Disease (AD) remains the major form of Dementia. Progressive neuronal loss is the major cause for the disease; however, the etiology of AD remains a controversial topic. Excessive oxidative stress, Tau hyperphosphorylation and formation of intracellular neurofibrillary tangles, as well as accumulation of extracellular Amyloid beta plaques represent the main targets for finding a cure. There is currently no effective treatment available for AD. Loss of cellular antioxidants including Thioredixin-1 (Trx1) is observed in AD tissue samples. Trx1 is a small redox reductase protein responsible for maintaining the oxidized proteins. Examining the importance of Trx1 depletion in pathology of AD, we have previously shown that pharmacological and genetic inhibition of Trx1 impairs autophagy, a vital housekeeping process responsible for protein homeostasis in neurons. We also have identified that loss of Trx1 is an important upstream event in induction of neuronal nuclear lamina invagination. Nuclear lamina damage or laminopathy is a newly identified mechanism in pathophysiology of AD. In the current studies we use genetic inhibition of Trx1 in human neuroblastoma cells and examine the effect on nuclear events. Our results indicate that downregulation of Trx1 is sufficient for induction of NL damage. These results lead to histone modification and changes in nuclear chromatin methylation. These studies were also complemented in hippocampi tissues from a mouse model of neuronal specific Trx1 knockout. Downregulation of Trx1 in these mice was associated with nuclear lamina damage and accumulation of amyloid beta and Tau hyperphosphorylation. Our studies provide a mechanistic link between oxidative stress and the key downstream events observed in AD pathology.

Nuclear Laminopathy and oxidative stress in Alzheimer's Disease

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PS-3-C -  Disorders of the Nervous System

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Colleagues and Friends:

I am very happy to welcome you to the 14th annual Canadian Neuroscience Meeting, and to the first virtual edition of our meeting. I want to highlight the important work the CAN meeting chair, **Roger Thompson** and co-chair, **Alyson Fournier**, did to put together the great program we are offering this year. Moving to a virtual format required a complete re-design of the program, and both Roger and Alyson did a splendid job in providing us with an appealing and well adapted program for our first virtual event. I wish to thank them for this very important effort.

Highlights of this year’s scientific meeting include invited speakers **Michael Hausser, Franck Polleux, Gwyneth Card, Magdalena Götz**and Brain Prize winner **Huda Zoghbi**. Plenary and parallel symposia, proposed by our members complete our diverse [scientific program.](https://can-acn.org/meeting-2021/program-2021/)

The 2021 Advocacy session, chaired and organized by CAN advocacy committee chair **Karun Singh**, will feature a special lecture and question period with Member of Parliament and past Science Minister **Kirsty Duncan**. This will be followed by a short overview of CAN’s advocacy activities over the last year. We invite you to participate in this session for insight from Dr. Duncan on the workings of Parliament Hill, and to learn more about what CAN has been doing to promote neuroscience research in Canada.

We are also excited to host **Lisa Willis** in the Equity Diversity and Inclusion session, organized by EDI committee chair **Jibran Khokhar**.

A special highlight of our meeting will be the lectures by award-winning young neuroscientists. We are please to host the CAN 2020 Young Investigator Award winner **Mihaela Iordanova**, and CAN 2021 Young Investigator Award winners **Aaron Phillips** and **Tabrez Siddiqui**. Highlights will also include presentation by the top three winners of the CAN-CIHR-INMHA Brain Star Award winners, **Claire Gizowski, Nuria Daviu Abant** and **Lukas Tamayo-Orrego**.

Independently organized satellite symposia complement and complete this exciting program, check them out here: https://can-acn.org/meeting-2021/2021-satellite-symposia/

Some of the most engaging sessions are always the poster sessions featuring the work of our trainees, so make sure to log in to Gather Town during the poster sessions to chat with the presenters.
We hope you enjoy this program, and look forward to welcoming you, virtually.

Shernaz Bamji

President of the Canadian Association for Neuroscience

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Eftekhar Eftekharpour

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Nuclear Laminopathy and oxidative stress in Alzheimer's Disease

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