The subventricular zone neurogenic niche receives neuronal inputs from many areas of the brain. Although these inputs are known to regulate neurogenesis through neurotransmitter release at synapse-like connections between neuronal axon terminals and neural stem and progenitor cells (NPCs), few studies have examined how neuronal modulators at these synapse-like connections affect SVZ NPC function. Our recent work identified monoacylglycerol lipase (Mgll), a hydrolase that breaks down endocannabinoid 2-AG, as an extrinsic factor to regulate SVZ NPC function in culture. 2-AG is a well-known retrograde modulator that controls neurotransmitter release. To date, it remains unknown how Mgll-modulated 2-AG signaling in the SVZ niche regulate SVZ NPC behavior in vivo. In this regard, we propose to examine the role of neuronal Mgll activity from distinct brain region in regulating SVZ NPC function. Using retrograde monosynaptic rabies virus tracing and anterograde tracing, we identified direct synapse-like connections between hypothalamic arcuate nucleus (ARC) neuron axon terminals and a subpopulation of NPCs residing in the ventral SVZ microdomain as previously reported. Intriguingly, specific removal of Mgll expression in ARC neurons using virally transfected Cre recombinase in Mgll-floxed mice resulted in a decrease of SVZ NPCs in this microdomain and a subsequent reduction of proliferating cells in this microdomain. These findings provide an understanding of how long-range neuronal Mgll activity regulates adult SVZ NPC function in a microdomain-specific fashion.

Long-range hypothalamic neuronal projections to the subventricular zone neurogenic niche regulates neural stem cell function through endocannabinoid signaling

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PS-3-E -  Homeostatic and Neuroendocrine Systems

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Colleagues and Friends:

I am very happy to welcome you to the 14th annual Canadian Neuroscience Meeting, and to the first virtual edition of our meeting. I want to highlight the important work the CAN meeting chair, **Roger Thompson** and co-chair, **Alyson Fournier**, did to put together the great program we are offering this year. Moving to a virtual format required a complete re-design of the program, and both Roger and Alyson did a splendid job in providing us with an appealing and well adapted program for our first virtual event. I wish to thank them for this very important effort.

Highlights of this year’s scientific meeting include invited speakers **Michael Hausser, Franck Polleux, Gwyneth Card, Magdalena Götz**and Brain Prize winner **Huda Zoghbi**. Plenary and parallel symposia, proposed by our members complete our diverse [scientific program.](https://can-acn.org/meeting-2021/program-2021/)

The 2021 Advocacy session, chaired and organized by CAN advocacy committee chair **Karun Singh**, will feature a special lecture and question period with Member of Parliament and past Science Minister **Kirsty Duncan**. This will be followed by a short overview of CAN’s advocacy activities over the last year. We invite you to participate in this session for insight from Dr. Duncan on the workings of Parliament Hill, and to learn more about what CAN has been doing to promote neuroscience research in Canada.

We are also excited to host **Lisa Willis** in the Equity Diversity and Inclusion session, organized by EDI committee chair **Jibran Khokhar**.

A special highlight of our meeting will be the lectures by award-winning young neuroscientists. We are please to host the CAN 2020 Young Investigator Award winner **Mihaela Iordanova**, and CAN 2021 Young Investigator Award winners **Aaron Phillips** and **Tabrez Siddiqui**. Highlights will also include presentation by the top three winners of the CAN-CIHR-INMHA Brain Star Award winners, **Claire Gizowski, Nuria Daviu Abant** and **Lukas Tamayo-Orrego**.

Independently organized satellite symposia complement and complete this exciting program, check them out here: https://can-acn.org/meeting-2021/2021-satellite-symposia/

Some of the most engaging sessions are always the poster sessions featuring the work of our trainees, so make sure to log in to Gather Town during the poster sessions to chat with the presenters.
We hope you enjoy this program, and look forward to welcoming you, virtually.

Shernaz Bamji

President of the Canadian Association for Neuroscience

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Edward Sun

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Long-range hypothalamic neuronal projections to the subventricular zone neurogenic niche regulates neural stem cell function through endocannabinoid signaling

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