The ability to automatically generate accurate protocols for scientific experiments would represent a major step towards the automation of science. Large Language Models (LLMs) have impressive capabilities on a wide range of tasks, such as question answering and the generation of coherent text and code. However, LLMs can struggle with multi-step problems and long-term planning, which are crucial for designing scientific experiments. Moreover, evaluation of the accuracy of scientific protocols is challenging, because experiments can be described correctly in many different ways, require expert knowledge to evaluate, and cannot usually be executed automatically. Here we present an automatic evaluation framework for the task of planning experimental protocols, and we introduce BioProt: a dataset of biology protocols with corresponding pseudocode representations. To measure performance on generating scientific protocols, we use an LLM to convert a natural language protocol into pseudocode, and then evaluate an LLM's ability to reconstruct the pseudocode from a high-level description and a list of admissible pseudocode functions. We evaluate GPT-3 and GPT-4 on this task and explore their robustness. We externally validate the utility of pseudocode representations of text by generating accurate novel protocols using retrieved pseudocode, and we run a generated protocol successfully in our biological laboratory. Our framework is extensible to the evaluation and improvement of language model

BioPlanner: Automatic Evaluation of LLMs on Protocol Planning in Biology | VIDEO

Planning for goal-oriented dialogue often requires simulating future dialogue interactions and estimating task progress. Many approaches thus consider training neural networks to perform look-ahead search algorithms such as A* search and Monte Carlo Tree Search (MCTS). However, this training often require abundant annotated data, which creates challenges when faced with noisy annotations or low-resource settings. We introduce GDP-Zero, an approach using Open-Loop MCTS to perform goal-oriented dialogue policy planning without any model training. GDP-Zero prompts a large language model to act as a policy prior, value function, user simulator, and system model during the tree search. We evaluate GDP-Zero on the goal-oriented task PersuasionForGood, and find that its responses are preferred over ChatGPT up to 59.32% of the time, and are rated more persuasive than ChatGPT during interactive evaluations.

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BioPlanner: Automatic Evaluation of LLMs on Protocol Planning in Biology | VIDEO

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