Controlling on their body size, several bird taxa show cognitive abilities outperforming the mammals. This applies namely to parrots and passerines. Yet, in birds we still have only limited information about the physiological circuits regulating the nervous system including neuro-immune interactions. In our previous research we have identified a gene loss of an important neuro-immune regulator CNR2 that is specific for parrots. Compared to songbirds parrots show significantly higher expression of pro-inflammatory markers (IL1B and IL6) in brains of individuals with sterile-induced abdominal inflammation. Parrots frequently suffer from behavioural disorders (depression and feather plucking) that can result from impaired inflammatory regulation. Here we measured gene expression of important neuropeptides that are involved in regulation of behaviour in brains and periphery (ileum) of parrots during acute neuroinflammation. Unlike in brain in the ileum we have identified differential gene expression of POMC. Next we compared the patterns of neuropeptides expression during acute inflammation to chronic inflammation. We have revealed association between expression of key pro-inflammatory cytokines and several neuropeptides (NPY, PDYN, POMC, TAC1 and VIP). Finally, we followed the relationships between cytokine and neuropeptide expression and behavioural patterns in the experimental animals. Our results support the importance of neuro-immune interactions in regulation of avian behaviour during inflammatory conditions. Targeting neuropeptide expression during chronic inflammation could offer novel therapeutic strategies to treat depression-like disorders in parrots.