Climate change causes significant changes in aquatic and terrestrial habitats, making them more susceptible to invasive species relative to native ones. However, our understanding of how metabolic responses to environmental stressors facilitate biological invasions is limited. In this study, we measured the metabolism of native (Gammarus pulex) and invasive (Dikerogammarus villosus) amphipods under different thermal and predation risk conditions to determine the plasticity of each species. We discovered an interactive and species-dependent effect of temperature and predation risk on the body-mass scaling of metabolic rate. The metabolic scaling relationship of the invasive species was insensitive to temperature changes, in contrast to that of the native species. Our results suggest that invasive species are less sensitive to increasing temperature, which may facilitate their invasion success in habitats vulnerable to global warming or at thermally polluted locations. Moreover, both species limited their metabolic responses to predation risk when the temperature increased, which may have negative implications for their defensive responses. Thus, attempts to understand effects of global warming in isolation from additional factors, such as predation pressure or taxonomic identity of species dominating in local communities, may lead to underestimation of its true ecological consequences