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The most recent approaches for clustering single-cell RNA-sequencing data rely on deep auto-encoders. However, three major challenges remain unaddressed. First, current models overlook the impact of the cumulative errors induced by the pseudo-supervised embedding clustering task (Feature Randomness). Second, existing methods neglect the effect of the strong competition between embedding clustering and reconstruction (Feature Drift). Third, the previous deep clustering models regularly fail to consider the topological information of the latent data, even though the local and global latent configurations can bring complementary views to the clustering task. To address these challenges, we propose a novel approach that explores the interaction between local and global latent configurations to progressively adjust the reconstruction and embedding clustering tasks. We elaborate a topological and probabilistic filter to mitigate Feature Randomness and a cell-cell graph structure and content correction mechanism to counteract Feature Drift. The Zero-Inflated Negative Binomial model is also integrated to capture the characteristics of gene expression profiles. We conduct detailed experiments on real-world datasets from multiple representative genome sequencing platforms. Our approach outperforms the state-of-the-art clustering methods in various evaluation metrics. 

AAAI 2023

Exploring the Interaction between Local and Global Latent Configurations for Clustering Single-cell RNA-seq: A Unified Perspective

single-cell rna sequencing data

deep clustering

unsupervised learning

ICPR 2020 is the premier international conference on Pattern Recognition, gathering leading researchers from around the world to present their latest achievements in Pattern Analysis and Recognition, applied Artificial Intelligence and Machine Learning. The topic of the year is " Putting Artificial intelligence to work on Patterns". 
For the first time, ICPR has employed a two-round review process similar to journal submissions, with new papers allowed to be submitted in either the first or second round and papers submitted in the first round and not accepted allowed to be revised and re-submitted for second round review. 

In this edition of the **ICPR 2020** Conference, there are 1407 Oral/Poster presentations organized in five Tracks: 
- Artificial Intelligence, Machine Learning for Pattern Analysis; 
- Biometrics, Human Analysis and Behavior Understanding; Computer Vision, Robotics and Intelligent Systems; 
- Document and Media Analysis; and 
- Image and Signal Processing. 

The **ICPR 2020** Main Conference program also includes 7 Keynotes from prominent world-renowned scientists, 8 Tutorials, 28 Demos, 8 Challenges, 2 Panels, as well as an Industry/Sponsor Exhibition. In addition, 41 Workshops on a range of important current and emerging research topics complete the ICPR 2020 program. 


ICPR 2020

poster

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-23 is the Thirty-Seventh AAAI Conference on Artificial Intelligence. The theme of this conference is to create collaborative bridges within and beyond AI. Like previous AAAI conferences, AAAI-23 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and two new activities: a Bridge Program and a Lab Program. Many of these activities are tailored to the theme of bridges and all are selected according to the highest standards, with additional programs for students and young researchers. 
AAAI is providing you with a conference planner, which you can use to help organize your itinerary of activities. This includes talks to attend in person, talks to attend remotely, breaks with colleagues and your site seeing activities. To access this conference planner, please go to [https://aaai-2023.takemobi.io](https://aaai-2023.takemobi.io).

In order to access this site, you need to register. If you haven't already, please register [here](https://aaai.org/Conferences/AAAI-23/registration/).


The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines.

Various contrastive learning approaches have been proposed in recent years and achieve significant empirical success. While effective and prevalent, contrastive learning has been less explored for time series data. A key component of contrastive learning is to select appropriate augmentations imposing some priors to construct feasible positive samples, such that an encoder can be trained to learn robust and discriminative representations. Unlike image and language domains where ``desired'' augmented samples can be generated with the rule of thumb guided by prefabricated human priors, the ad-hoc manual selection of time series augmentations is hindered by their diverse and human-unrecognizable temporal structures. How to find the desired augmentations of time series data that are meaningful for given contrastive learning tasks and datasets remains an open question. In this work, we address the problem by encouraging both high \textit{fidelity} and \textit{variety} based upon information theory. A theoretical analysis leads to the criteria for selecting feasible data augmentations. On top of that, we propose a new contrastive learning approach with information-aware augmentations, InfoTS, that adaptively selects optimal augmentations for time series representation learning. Experiments on various datasets show highly competitive performance with up to 12.0\% reduction in MSE on forecasting tasks and up to 3.7\% relative improvement in accuracy on classification tasks over the leading baselines.

Time Series Contrastive Learning with Information-Aware Augmentations

Learning from raw high dimensional data via interaction with a given environment has been effectively achieved through the utilization of deep neural networks. Yet the observed degradation in policy performance caused by imperceptible worst-case policy dependent translations along high sensitivity directions (i.e. adversarial perturbations) raises concerns on the robustness of deep reinforcement learning policies. In our paper, we show that these high sensitivity directions do not lie only along particular worst-case directions, but rather are more abundant in the deep neural policy landscape and can be found via more natural means in a black-box setting. Furthermore, we show that vanilla training techniques intriguingly result in learning more robust policies compared to the policies learnt via the state-of-the-art adversarial training techniques. We believe our work lays out intriguing properties of the deep reinforcement learning policy manifold and our results can help to build robust and generalizable deep reinforcement learning policies.

Adversarial Robust Deep Reinforcement Learning Requires Redefining Robustness

Cross entropy loss has served as the main objective function for classification-based tasks. Widely deployed for learning neural network classifiers, it shows both effectiveness and a probabilistic interpretation.  Recently, after the success of self supervised contrastive representation learning methods, supervised contrastive methods have been proposed to learn representations and have shown superior and more robust performance, compared to solely training with cross entropy loss. However, cross entropy loss is still needed to train the final classification layer. In this work, we investigate the possibility of learning both the representation and the classifier using one objective function that combines the robustness of contrastive learning and the probabilistic interpretation of  cross entropy loss. First,  we revisit a previously proposed contrastive-based objective function that approximates cross entropy loss and present a simple extension to learn  the classifier jointly. Second, we propose a new version of the supervised contrastive training that learns jointly the parameters of the classifier and the backbone of the network. We empirically show that these proposed objective functions demonstrate state-of-the-art performance and show a significant improvement over the standard cross entropy loss with more training stability and robustness in various challenging settings.

Contrastive Classification and Representation Learning with Probabilistic Interpretation

We present Progressively Deblurring Radiance Field (PDRF), a novel approach to efficiently reconstruct high quality radiance fields from blurry images. While current State-of-The-Art (SoTA) scene reconstruction methods achieve photo-realistic renderings from clean source views, their performances suffer when the source views are affected by blur, which is commonly observed in the wild. Previous deblurring methods either do not account for 3D geometry, or are computationally intense. To addresses these issues, PDRF uses a progressively deblurring scheme for radiance field modeling, which can accurately model blur with 3D scene context. PDRF further uses an efficient importance sampling scheme and results in fast scene optimization. We perform extensive experiments and show that PDRF is 15X faster than previous SoTA while achieving better performance on both synthetic and real scenes.

PDRF: Progressively Deblurring Radiance Field for Fast Scene Reconstruction from Blurry Images

Sequential Recommender Systems (SRSs) aim to predict the next item that users will consume, by modeling the user interests within their item sequences. While most existing SRSs focus on a single type of user behavior, only a few pay attention to multi-behavior sequences, although they are very common in real-world scenarios. It is challenging to effectively capture the user interests within multi-behavior sequences, because the information about user interests is entangled throughout the sequences in complex relationships. To this end, we first address the characteristics of multi-behavior sequences that should be considered in SRSs, and then propose novel methods for Dynamic Multi-behavior Sequence modeling named DyMuS, which is a light version, and DyMuS+, which is an improved version, considering the characteristics. DyMuS first encodes each behavior sequence independently, and then combines the encoded sequences using dynamic routing, which dynamically integrates information required in the final result from among many candidates, based on correlations between the sequences. DyMuS+, furthermore, applies the dynamic routing even to encoding each behavior sequence to further capture the correlations at item-level. Moreover, we release a new, large and up-to-date dataset for multi-behavior recommendation. Our experiments on DyMuS and DyMuS+ show their superiority and the significance of capturing the characteristics of multi-behavior sequences.

Dynamic Multi-Behavior Sequence Modeling for Next Item Recommendation

The recently proposed Vision transformers (ViTs) have shown
very impressive empirical performance in various computer vision tasks,
and they are viewed as an important type of foundation model. However, ViTs are typically constructed with large-scale sizes, which then
severely hinder their potential deployment in many practical resources constrained applications. To mitigate this challenging problem, structured pruning is a promising solution to compress model size and enable
practical efficiency. However, unlike its current popularity for CNNs and
RNNs, structured pruning for ViT models is little explored.
In this paper, we propose GOHSP, a unified framework of Graph and
Optimization-based Structured Pruning for ViT models. We first develop
a graph-based ranking for measuring the importance of attention heads,
and the extracted importance information is further integrated to an
optimization-based procedure to impose the heterogeneous structured
sparsity patterns on the ViT models. Experimental results show that
our proposed GOHSP demonstrates excellent compression performance.
On CIFAR-10 dataset, our approach can bring 40% parameters reduction
with no accuracy loss for ViT-Small model. On ImageNet dataset, with
30% and 35% sparsity ratio for DeiT-Tiny and DeiT-Small models, our
approach achieves 1.65% and 0.76% accuracy increase over the existing
structured pruning methods, respectively.

GOHSP: A Unified Framework of Graph and Optimization-based Heterogeneous Structured Pruning for Vision Transformer

It is known that neural networks have the problem of being over-confident when directly using the output label distribution to generate uncertainty measures. Existing methods mainly resolve this issue by retraining the entire model to impose the uncertainty quantification capability so that the learned model can achieve desired performance in accuracy and uncertainty prediction simultaneously. However, training the model from scratch is computationally expensive, and a trade-off might exist between prediction accuracy and uncertainty quantification. To this end, we consider a more practical post-hoc uncertainty learning setting, where a well-trained base model is given, and we focus on the uncertainty quantification task at the second stage of training. We propose a novel Bayesian uncertainty learning approach using the Dirichlet meta-model, which is effective and computationally efficient. Our proposed method requires no additional training data and is flexible enough to quantify different uncertainties and easily adapt to different application settings, including out-of-domain data detection, misclassification detection, and trustworthy transfer learning. Finally, we demonstrate our proposed meta-model approach's flexibility and superior empirical performance on these applications over multiple representative image classification benchmarks.

Post-hoc Uncertainty Learning using a Dirichlet Meta-Model

Subsampling algorithms are a natural approach to reduce data size before fitting models on massive datasets. In recent years, several works have proposed methods for subsampling rows from a data matrix while maintaining relevant information for classification. While these works are supported by theory and limited experiments, to date there has not been a comprehensive evaluation of these methods. In our work, we directly compare multiple methods for logistic regression drawn from the coreset and optimal subsampling literature and discover inconsistencies in their effectiveness. In many cases, methods do not outperform simple uniform subsampling.

A Coreset Learning Reality Check

We present a simple and yet effective interpolation-based regularization technique, aiming to improve the generalization of Graph Neural Networks (GNNs) on supervised graph classification. We leverage Mixup, an effective regularizer for vision, where random sample pairs and their labels are interpolated to create synthetic images for training. Unlike images with grid-like samples, graphs have arbitrary structure and topology, which can be very sensitive to any modification in terms of a graph's semantic meanings. This posts two unanswered questions:   Can we directly mixing up a pair of graph inputs?   If so, how well does such mixing strategy regularize the learning of GNNs?  To answer these two questions, we propose ifMixup, which adds dummy nodes to make two graphs have the same input size and then directly interpolates the two graph inputs. We empirically show that such simple mixing strategy can effectively regularize the graph classification learning, resulting in superior predictive accuracy to popular graph augmentation baselines. 

Interpolating Graph Pair to Regularize Graph Classification

Hierarchical reinforcement learning (HRL) proposes to solve difficult tasks by performing decision-making and control at successively higher levels of temporal abstraction. However, off-policy HRL often suffers from the problem of a non-stationary high-level policy since the low-level policy is constantly changing. In this paper, we propose a novel HRL approach for mitigating the non-stationarity by adversarially enforcing the high-level policy to generate subgoals compatible with the current instantiation of the low-level policy. In practice, the adversarial learning is implemented by training a simple state conditioned discriminator network concurrently with the high-level policy which determines the compatibility level of subgoals. Comparison to state-of-the-art algorithms shows that our approach improves both learning efficiency and performance in challenging continuous control tasks.

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Exploring the Interaction between Local and Global Latent Configurations for Clustering Single-cell RNA-seq: A Unified Perspective

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Time Series Contrastive Learning with Information-Aware Augmentations

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