United States

The opioid overdose epidemic represents a serious public health crisis, with fatality rates rising considerably over the past several years. To help address the abuse of prescription opioids, state governments collect data on dispensed prescriptions, yet the use of these data is typically limited to manual searches. In this paper, we propose a novel graph-based framework for detecting anomalous opioid prescribing patterns in state Prescription Drug Monitoring Program (PDMP) data, which could aid governments in deterring opioid diversion and abuse. Specifically, we seek to identify connected networks of opioid prescribers and dispensers who engage in high-risk and possibly illicit activity. We develop and apply a novel extension of the Non-Parametric Heterogeneous Graph Scan (NPHGS) to two years of de-identified PDMP data from the state of Kansas, and find that NPHGS identifies subgraphs that are significantly more anomalous than those detected by other graph-based methods. NPHGS also reveals clusters of potentially illicit activity, which may strengthen state law enforcement and regulatory capabilities. Our paper is the first to demonstrate how prescription data can systematically identify anomalous opioid prescribers and dispensers, as well as illustrating the efficacy of a network-based approach. Additionally, our technical extensions to NPHGS offer both improved flexibility and graph density reduction, enabling the framework to be replicated across jurisdictions and extended to other problem domains.

AAAI 2023

Detecting Anomalous Networks of Opioid Prescribers and Dispensers in Prescription Drug Data

graph-based machine learning

anomaly detection

clustering

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-23 is the Thirty-Seventh AAAI Conference on Artificial Intelligence. The theme of this conference is to create collaborative bridges within and beyond AI. Like previous AAAI conferences, AAAI-23 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and two new activities: a Bridge Program and a Lab Program. Many of these activities are tailored to the theme of bridges and all are selected according to the highest standards, with additional programs for students and young researchers. 
AAAI is providing you with a conference planner, which you can use to help organize your itinerary of activities. This includes talks to attend in person, talks to attend remotely, breaks with colleagues and your site seeing activities. To access this conference planner, please go to [https://aaai-2023.takemobi.io](https://aaai-2023.takemobi.io).

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The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines.

poster

Generative Adversarial Networks (GANs) have shown compelling results in various tasks and applications in recent years. However, mode collapse remains a critical problem in GANs. In this paper, we propose a novel training pipeline to address the mode collapse issue of GANs. Different from existing methods, we propose to generalize the discriminator as feature embedding and maximize the entropy of distributions in the embedding space learned by the discriminator. Specifically, two regularization terms, i.e., Deep Local Linear Embedding (DLLE) and Deep Isometric feature Mapping (DIsoMap), are designed to encourage the discriminator to learn the structural information embedded in the data, such
that the embedding space learned by the discriminator can be well-formed. Based on the well-learned embedding space supported by the discriminator, a non-parametric entropy estimator is designed to efficiently maximize the entropy of embedding vectors, playing as an approximation of maximizing the entropy of the generated distribution. By improving the discriminator and maximizing the distance of the most similar samples in the embedding space, our pipeline effectively reduces the mode collapse without sacrificing the quality of generated samples. Extensive experimental results show the effectiveness of our method which outperforms the GAN baseline, MaF-GAN on CelebA (9.13 vs. 12.43 in FID) and surpasses the recent state-of-the-art energy-based model on the ANIMEFACE dataset (2.80 vs. 2.26 in Inception score).

Combating Mode Collapse via Offline Manifold Entropy Estimation

Understanding the informative structures of scenes is essential for low-level vision tasks. Unfortunately, it is difficult to obtain a concrete visual definition of the informative structures because influences of visual features are task-specific.
In this paper, we propose a single general neural network architecture for extracting task-specific structure guidance for scenes. To do this, we first analyze traditional spectral clustering methods, which computes a set of eigenvectors to model a segmented graph forming small compact structures on image domains. We then unfold the traditional graph-partitioning problem into a learnable network, named Scene Structure Guidance Network (SSGNet), to represent the task-specific informative structures.  The SSGNet yields a set of coefficients of eigenvectors that produces explicit feature representations of image structures. In addition, our SSGNet is light-weight ($\sim$ 55K parameters), and can be used as a plug-and-play module for off-the-shelf architectures. We optimize the SSGNet without any supervision by proposing two novel training losses that enforce task-specific scene structure generation during training. Our main contribution is to show that such a simple network can achieve state-of-the art results for several low-level vision applications including joint upsampling and image denoising. Our submitted source codes also demonstrate that our SSGNet generalizes well on unseen datasets, compared to existing methods which use structural embedding frameworks.

Task-specific Scene Structure Representations

Spatial-temporal (ST) graph modeling, such as traffic speed forecasting and taxi demand prediction, is an important task in deep learning area.
However, for the nodes in the graph, their ST patterns can vary greatly in difficulties for modeling, owning to the heterogeneous nature of ST data. We argue that unveiling the nodes to the model in a meaningful order, from easy to complex, can provide performance improvements over traditional training procedure. The idea has its root in Curriculum Learning, which suggests in the early stage of training models can be sensitive to noise and difficult samples. In this paper, we propose ST-Curriculum Dropout, a novel and easy-to-implement strategy for spatial-temporal graph modeling. Specifically, we evaluate the learning difficulty of each node in high-level feature space and drop those difficult ones out to ensure the model only needs to handle fundamental ST relations at the beginning, before gradually moving to hard ones. Our strategy can be applied to any canonical deep learning architecture without extra trainable parameters, and extensive experiments on a wide range of datasets are conducted to illustrate that, by controlling the difficulty level of ST relations as the training progresses, the model is able to capture better representation of the data and thus yields better generalization. 

Easy Begun is Half Done: Spatial-Temporal Graph Modeling with ST-Curriculum Dropout

Recently, the joint learning framework (JOINT) integrates matching based transductive reasoning and online inductive learning to achieve accurate and robust semi-supervised video object segmentation (SVOS). However, using the mask embedding as the label to guide the generation of target features in the two branches may result in inadequate target representation and degrade the performance. Besides, how to reasonably fuse the target features in the two different branches rather than simply adding them together to avoid the adverse effect of one dominant branch has not been investigated. In this paper, we propose a novel framework that emphasizes Learning to Learn Better (LLB) target features for SVOS, termed LLB, where we design the discriminative label generation module (DLGM) and the adaptive fusion module to address these issues. Technically, the DLGM takes the background-filtered frame instead of the target mask as input and adopts a lightweight encoder to generate the target features, which serves as the label of the online few-shot learner and the value of the decoder in the transformer to guide the two branches to learn more discriminative target representation. The adaptive fusion module maintains a learnable gate for each branch, which reweighs the element-wise feature representation and allows an adaptive amount of target information in each branch flowing to the fused target feature, thus preventing one branch from being dominant and making the target feature more robust to distractor. Extensive experiments on public benchmarks show that our proposed LLB method achieves state-of-the-art performance.

Learning to Learn Better for Video Object Segmentation

Goal Recognition is the task of discerning the intended goal of an agent given a sequence of observations, whereas Plan Recognition consists of identifying the plan to achieve such intended goal. Regardless of the underlying techniques, most recognition approaches are directly affected by the quality of the available observations. In this paper, we develop neuro-symbolic recognition approaches that can combine learning and planning techniques, compensating for noise and missing observations using prior data. We evaluate our approaches in standard human-designed planning domains as well as domain models automatically learned from real-world data. Empirical experimentation shows that our approaches reliably infer goals and compute correct plans in the experimental datasets. An ablation study shows that outperform approaches that rely exclusively on the domain model, or exclusively on machine learning in problems with both noisy observations and low observability.

Robust Neuro-Symbolic Goal and Plan Recognition

Unsupervised text-graph alignment (UTGA) is a fundamental task that bidirectionally generates texts and graphs without parallel data. Most available models of UTGA suffer from information asymmetry, a common phenomenon that texts and graphs include additional information invisible to each other. On the one hand, these models fail to supplement asymmetric information effectively due to the lack of ground truths. On the other hand, it is challenging to indicate asymmetric information with explicit indicators because it cannot be decoupled from the data directly. To address the challenge posed by information asymmetry, we propose the assumption that asymmetric information is encoded in unobservable latent variables and only affects the one-way generation processes. These latent variables corresponding to asymmetric information should obey prior distributions recovered approximately from original data. Therefore, we first propose a taxonomy of the latent variable that classifies the latent variable into transferrable (TV) and non-transferable (NTV) variables and further distinguish NTV as the dependent variable (DV) and the independent variable (IV). Next, we propose three latent VAE-based regularizations on TV, DV, and IV to constrain their distributions to well-designed prior distributions to introduce asymmetric information into models and enhance the preservation of shared contents. Finally, we impose the three proposed constraints on a cycle-consistent learning framework, back-translation (BT), named ConstrainedBT. Experimental results on three UTGA tasks demonstrate the effectiveness of ConstrainedBT on the information-asymmetric challenge.

Latent Constraints on Unsupervised Text-Graph Alignment with Information Asymmetry

Machine learning systems are often deployed for making critical decisions like credit lending, hiring, etc. While making decisions, such systems often encode the user's demographic information (like gender, age) in their intermediate representations. This can lead to decisions that are biased towards specific demographics. Prior work has focused on  debiasing intermediate representations to ensure fair decisions. However, these approaches fail to remain fair with changes in the task or demographic distribution. To ensure fairness in the wild, it is important for a system to adapt to such changes as it accesses new data in an incremental fashion.  In this work, we propose to address this issue by introducing the problem of learning fair representations in an incremental learning setting. To this end, we present Fairness-aware Incremental Representation Learning (FaIRL), a representation learning system that can sustain fairness while incrementally learning new tasks. FaIRL is able to achieve fairness and learn new tasks by controlling the rate-distortion function of the learned representations. Our empirical evaluations show that FaIRL is able to make fair decisions while achieving high performance on the target task, outperforming several baselines. 

Sustaining Fairness via Incremental Learning

Automatic International Classification of Diseases (ICD) coding aims to assign multiple ICD codes to a medical note with an average of 3,000+ tokens. This task is challenging due to the high-dimensional space of multi-label assignment (155,000+ ICD code candidates) and the long-tail challenge - Many ICD codes are infrequently assigned yet infrequent ICD codes are important clinically. This study addresses the long-tail challenge by transforming this multi-label classification task into an autoregressive generation task. Specifically, we first introduce a novel pretraining objective to generate free text diagnosis and procedure descriptions using the SOAP structure, the medical logic physicians use for note documentation. Second, instead of directly predicting the high dimensional space of ICD codes, our model generates the lower dimension of text descriptions, which then infer ICD codes. Third, we designed a novel prompt template for multi-label classification. We evaluate our Generation with Prompt (GP) model with the benchmark of all code assignment (MIMIC-III-full) and few shot ICD code assignment evaluation benchmark (MIMIC-III-few). Experiments on MIMIC-III-few show that our model performs with a marco F1 30.2, which substantially outperforms the previous MIMIC-III-full SOTA model (marco F1 4.3) and the model specifically designed for few/zero shot setting (marco F1 18.7). Finally, we design a novel ensemble learner, a cross attention reranker with prompts, to integrate previous SOTA and our best few-shot coding predictions. Experiments on MIMIC-III-full show that our ensemble learner substantially improves both macro and micro F1, from 10.4 to 14.6 and from 58.2 to 59.1, respectively. 

Multi-label Few-shot ICD Coding as Autoregressive Generation with Prompt

This paper studies how to train machine-learning models that directly approximate the optimal solutions of constrained optimization problems. This is an empirical risk minimization under constraints, which is challenging as training must balance optimality and feasibility conditions. Supervised learning methods often approach this challenge by training the model on a large collection of pre-solved instances. This paper takes a different route and proposes the idea of Primal-Dual Learning (PDL), a self-supervised training method that does not require a set of pre-solved instances or an optimization solver for training and inference. Instead, PDL mimics the trajectory of an Augmented Lagrangian Method (ALM) and jointly trains primal and dual neural networks. Being a primal-dual method, PDL uses instance-specific penalties of the constraint terms in the loss function used to train the primal network. Experiments show that, on a set of nonlinear optimization benchmarks, PDL typically exhibits negligible constraint violations and minor optimality gaps, and is remarkably close to the ALM optimization. PDL also demonstrated improved or similar performance in terms of the optimality gaps, constraint violations, and training times compared to existing approaches.

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