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The emergence of groundbreaking large language models capable of performing complex reasoning tasks holds significant promise for addressing various scientific challenges, including those arising in complex clinical scenarios. To enable their safe and effective deployment in real-world healthcare settings, it is urgently necessary to benchmark the diagnostic capabilities of current models systematically. Given the limitations of existing medical benchmarks in evaluating advanced diagnostic reasoning, we present DiagnosisArena, a comprehensive and challenging benchmark designed to rigorously assess professional-level diagnostic competence. DiagnosisArena consists of 1,113 pairs of segmented patient cases and corresponding diagnoses, spanning 28 medical specialties, deriving from clinical case reports published in 10 top-tier medical journals. The benchmark is developed through a meticulous construction pipeline, involving multiple rounds of screening and review by both AI systems and human experts, with thorough checks conducted to prevent data leakage. Our study reveals that even the most advanced reasoning models, o3-mini, o1, and DeepSeek-R1, achieve only 45.82%, 31.09%, and 17.79% accuracy, respectively. This finding highlights a significant generalization bottleneck in current large language models when faced with clinical diagnostic reasoning challenges. Through DiagnosisArena, we aim to drive further advancements in AI’s diagnostic reasoning capabilities, enabling more effective solutions for real-world clinical diagnostic challenges. We openly share the benchmark and evaluation tools for further research and development.

ACL 2026

DiagnosisArena: Benchmarking Diagnostic Reasoning for Large Language Models

### Welcome to ACL 2023, the 61st Annual Meeting of the Association for Computational Linguistics! 
 The conference will be held in Toronto, Canada, July 9-14, 2023. 
Following the succession of the recent conferences in our field, ACL 2023 will adopt a hybrid format.
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This General Chair’s message is where I express my gratitude to the many individuals who have made
enormous contributions to the conference over the past year.

Read [**ACL 2023 General Chair's message**](https://docs.google.com/document/d/1WobYM7norbG4dI48s75HfJoD89qgX5a_F-6U8AteLSA/edit?usp=sharing/) in full.

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ACL 2023

The Association for Computational Linguistics (ACL) is the premier international scientific and professional society for people working on computational problems involving human language, a field often referred to as either computational linguistics or natural language processing.

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It is my great pleasure and honor to welcome you to the 64th Annual Meeting of the Association for Computational Linguistics (ACL 2026), held in San Diego, California, USA, July 2–7, 2026. ACL 2026 continues our fields tradition of excellence in scholarship, innovation, and inclusivity, and I am deeply grateful to the many volunteers who have worked tirelessly to bring this event to life.

It is exciting to see the many developments in the field reflected at our conference, such as the advancement of large language models (born out of our community) into many application directions. This is not without challenges, partly due to unsolved problems, and partly due to misuse of the technology. All this is reflected well at ACL 2026. The conference also reflects that the field is not only about advancing technology, but also the science of fundamentally understanding language and how it is use by many different speaker communities. 
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The 64th Annual Meeting of the Association for Computational Linguistics (ACL 2026) will take place in San Diego, California, from July 2 - 7, 2026.

Identifying conditions that a certain drug takes therapeutic effect on a target disease is crucial for clinical decision-making support. However, most existing biomedical information extraction methods have focused on identifying only relations between drugs and diseases, while largely overlooking the context-specific conditions where such relations can apply. To address this problem, we introduce the task of applicability condition extraction for therapeutic drug--disease relations from biomedical research literature. We create the first dataset that has manually annotated triples of drugs, diseases, and applicability conditions on biomedical paper abstracts with 1,119 drug-disease pairs. Using this dataset, we systematically evaluate the performance of a range of existing methods. In addition, we propose a new method that enhances LoRA to consider relations between drugs and diseases. Our method consistently outperforms strong baselines across different evaluation settings.

Applicability Condition Extraction for Therapeutic Drug-Disease Relations

Editing presentation slides is a frequent yet tedious task, ranging from creative layout design to repetitive text maintenance. While recent GUI-based agents powered by Multimodal LLMs (MLLMs) excel at tasks requiring visual perception, such as spatial layout adjustments, they often incur high computational costs and latency when handling structured, text-centric, or batch processing tasks. In this paper, we propose Talk-to-Your-Slides, a high-efficiency slide editing agent that operates via language-driven structured data manipulation rather than relying on the image modality. By leveraging the underlying object model instead of screen pixels, our approach ensures precise content modification while preserving style fidelity, addressing the limitations of OCR-based visual agents. Our system features a hierarchical architecture that effectively bridges high-level user instructions with low-level execution codes. Experiments demonstrate that for text-centric and formatting tasks, our method enables 34% faster processing, achieves 34% better instruction fidelity, and operates at an 87% lower cost compared to GUI-based baselines. Furthermore, we introduce TSBench, a human-verified benchmark dataset comprising 379 instructions, including a Hard subset designed to evaluate robustness against complex and visually dependent queries. Our code and benchmark are available at https://drive.google.com/drive/folders/1onwp5m7t3207xZu7HEBTMpdivsiOuqG8?usp=share_link

 Talk to Your Slides: High-Efficiency Slide Editing via Language-Driven Structured Data Manipulation

Large language models (LLMs) are excellent at maintaining high-level, convincing dialogue, but it remains unclear whether their persuasive success reflects genuine understanding of the discourse. We examine this question through informal debates between humans and LLMs, first by measuring their persuasive skills, and then by relating these to their understanding of what is being talked about: namely, their comprehension of argumentative structures and the pragmatic context on the same debates. We find that LLMs effectively maintain coherent, persuasive debates, and can sway the beliefs of both participants and audiences. We also note that awareness or suspicion of AI involvement encourage people to be more critical of the arguments made. However, we also find that LLMs are unable to show comprehension of deeper dialogical structures, such as argument quality or existence of supporting premises. Our results reveal a disconnect between LLM comprehension and dialogical skills, raising ethical and practical concerns on their deployment on explanation-critical contexts. From an argumentation-theoretical perspective, we experimentally question whether an agent, if it can convincingly maintain a dialogue, is required to show it knows what is talking about.

The Thin Line Between Comprehension and Persuasion in LLMs

Agentic workflows solve complex tasks by orchestrating modular components (e.g., planning, reasoning, action, reflection) built on top of LLM backbones. A practical but underexplored question is model allocation: given a fixed workflow decomposition and a pool of candidate LLMs, which components should be upgraded (and with which models) to upgrade task performance, and how can we attribute gains to individual upgrades and their interactions?
We present ShapleyFlow, a cooperative game theoretic framework that models component upgrades as players and evaluates component coalitions to compute Shapley values. This yields interaction-aware attribution and supports Shapley-guided configuration recommendation for model allocation under a fixed workflow structure.
We further introduce CapaBench, a benchmark of 1,500+ tasks across seven domains (shopping, navigation, ticketing, mathematics, operating systems, robotic coordination, and automated theorem proving).
Across 9 representative LLMs and all $2^4$ upgrade coalitions in a 4-component workflow, ShapleyFlow provides (i) principled, interaction-aware attribution for modular workflows and (ii) actionable model-allocation recommendations that improve over strong single-model baselines.

 Attribution-Based Analysis and Optimization of Modular Agentic Workflows

Large Vision Language Models (LVLMs) have demonstrated remarkable capabilities, yet their proficiency in understanding and reasoning over multiple images remains largely unexplored. While existing benchmarks have initiated the evaluation of multi-image models, a comprehensive analysis of their core weaknesses and their causes is still lacking. In this work, we introduce MIMIC (Multi-Image Model Insights and Challenges), a new benchmark designed to rigorously evaluate the multi-image capabilities of LVLMs. Using MIMIC, we conduct a series of diagnostic experiments that reveal pervasive issues: LVLMs often fail to aggregate information across images and struggle to track or attend to multiple concepts simultaneously. To address these failures, we propose two novel complementary remedies. On the data side, we present a procedural data-generation strategy that composes single-image annotations into rich, targeted multi-image training examples. On the optimization side, we analyze layer-wise attention patterns and derive an attention-masking scheme tailored for multi-image inputs. Experiments substantially improved cross-image aggregation, while also enhancing performance on existing multi-image benchmarks, outperforming prior state of the art across tasks. Data and code will be made available.

More Images, More Problems? A Controlled Analysis of VLM Failure Modes.

Concept-based explanations quantify how high-level concepts (e.g., gender or experience) influence model behavior, which is crucial for decision-makers in high-stakes domains. Recent work evaluates the faithfulness of such explanations by comparing them to reference causal effects estimated from counterfactuals. In practice, existing benchmarks rely on costly human-written counterfactuals that serves as imperfect proxy. To address this, we introduce a framework for constructing datasets containing structural counterfactual pairs: LIBERTy (LLM-based Interventional Benchmark for Explainability with Reference Targets). LIBERTy is grounded in explicitly defined Structured Causal Models (SCMs) of the text generation, interventions on a concept propagate through the SCM until an LLM generates the counterfactual. We introduce three datasets (disease detection, CV screening, and workplace violence prediction) together with a new evaluation metric, order-faithfulness. Using them, we evaluate a wide range of methods across five models and identify substantial headroom for improving concept-based explanations. LIBERTy also enables systematic analysis of model sensitivity to interventions: we find that proprietary LLMs show markedly reduced sensitivity to demographic concepts, likely due to post-training mitigation. Overall, LIBERTy provides a much-needed benchmark for developing faithful explainability methods.

LIBERTy: A Causal Framework for Benchmarking Concept-Based Explanations of LLMs with Structural Counterfactuals

Large language models are increasingly deployed in multi-turn settings such as tutoring, support, and counseling, where reliability depends on preserving consistent roles, personas, and goals across long horizons. This requirement becomes critical when LLMs are used to generate synthetic dialogues for training and evaluation, since LLM–LLM conversations can accumulate identity-related failures such as persona drift, role confusion, and “echoing”, where one agent gradually mirrors its partner. We introduce SPASM (Stable Persona-driven Agent Simulation for Multi-turn dialogue generation), a modular, stability-first framework that decomposes simulation into (i) persona creation via schema sampling, plausibility validation, and natural-language persona crafting, (ii) Client–Responder dialogue generation, and (iii) termination detection for coherent stopping. To improve long-horizon stability without changing model weights, we propose Egocentric Context Projection (ECP): dialogue history is stored in a perspective-agnostic representation and deterministically projected into each agent’s egocentric view before generation. Across three LLM backbones (GPT-4o-mini, DeepSeek-V3.2, Qwen-Plus) and nine Client–Responder pairings, we construct a dataset of 4,500 personas and 45,000 conversations (500 personas × 10 conversations per pairing). Ablations show ECP substantially reduces persona drift and, under human validation, eliminates echoing; embedding analyses recover persona structure and reveal strong responder-driven interaction geometry. Our code is available at https://github.com/lhannnn/SPASM.

SPASM: Stable Persona-driven Agent Simulation for Multi-turn Dialogue Generation

Text-to-image (T2I) generative models have achieved remarkable progress, demonstrating exceptional capability in synthesizing high-quality images from textual prompts. While existing research and benchmarks have extensively evaluated the ability of T2I models to follow the literal meaning of prompts, their ability to reason over prompts with domain knowledge to uncover implicit meaning and contextual nuances remains underexplored. To bridge this gap, we introduce T2I-ReasonBench, a novel benchmark designed to explore the knowledge-driven reasoning capabilities of T2I models.
T2I-ReasonBench comprises 800 meticulously designed prompts organized into four dimensions: \textbf{(1) Idiom Interpretation}, \textbf{(2) Textual Image Design}, \textbf{(3) Entity Reasoning}, and \textbf{(4) Scientific Reasoning}. These dimensions challenge models to integrate domain knowledge, infer implicit meaning, and resolve contextual ambiguities. To quantify the performance, we introduce a two-stage evaluation framework: a large language model (LLM) generates prompt-specific question-criterion pairs that evaluate if the image includes the essential elements resulting from correct reasoning; a multimodal LLM (MLLM) then scores the generated image against these criteria. 
Our comprehensive study across 16 state-of-the-art diffusion and unified multimodal models (UMMs) reveal two primary bottlenecks. First, many models lack the foundational reasoning ability to fully comprehend complex prompts. Second, even models with stronger reasoning modules exhibit a persistent gap between their internal understanding and the final generated image. This highlights an urgent need for the next generation of T2I systems to not only improve their reasoning capability but also to enhance integration between reasoning and synthesis.

T2I-ReasonBench: Benchmarking Reasoning-Informed Text-to-Image Generation

Prompt underspecification is a common challenge when interacting with LLMs. In this paper, we present an in-depth analysis of this problem, showing that while LLMs can often infer unspecified requirements by default (41.1%), such behavior is fragile: Under-specified prompts are 2x as likely to regress across model or prompt changes, sometimes with accuracy drops exceeding 20%. This instability makes it difficult to reliably build LLM applications. Moreover, simply specifying all requirements does not consistently help, as models have limited instruction-following ability and requirements can conflict. Standard prompt optimizers likewise provide little benefit. To address these issues, we propose requirements-aware prompt optimization mechanisms that improve performance by 4.8% on average over baselines. We further advocate for a systematic process of proactive requirements discovery, evaluation, and monitoring to better manage prompt underspecification in practice.

What Prompts Don’t Say: Understanding and Managing Underspecification in LLM Prompts

Large language models (LLMs) can answer questions and summarize documents when conditioned on external contexts (e.g., retrieved evidence), yet context use remains unreliable: models may overwrite an already-correct output (neutral regression) even when the context is non-informative. We formalize neutral regression as a do-no-harm requirement and quantify it by measuring accuracy drops on baseline-correct items under answer-consistent contexts. We propose No-Worse Context-Aware Decoding (NWCAD), a decode-time adapter built on a two-stream setup with a two-stage gate: it backs off to no-context decoding when the context is non-informative, and otherwise uses context-conditioned decoding with a contrastive fallback under uncertainty. We evaluate NWCAD on benchmarks that separate do-no-harm reliability from context utilization (accuracy gains on genuinely helpful contexts). NWCAD prevents neutral regression on baseline-correct items while preserving strong context-driven accuracy on helpful contexts.

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Applicability Condition Extraction for Therapeutic Drug-Disease Relations

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