Singapore

Cell phenotype transition refers to the changes in the morphology, function, and surface markers of cells that occur under specific environmental conditions or physiological states, based on their genomic information and external signals. This process plays an important role in development, tissue repair, and responses to external stimuli such as infection or inflammation. Traditional bioinformatics methods for addressing cell type transition often rely on hypothesis-driven models, which may not fully capture the complexity and heterogeneity of the transition processes. In this paper, we introduce DualCPT, a cell phenotype transition and differentiation model based on Markov processes. Specifically, the model consists of a classification branch and a transition branch. The transition branch identifies regulatory genes involved in cell phenotype transition and differentiation. In the classification branch, we evaluate the model’s overall performance on general cell type classification tasks using a comprehensive multi-metric evaluation framework; in the transition branch, we implement a token pruning-based approach for critical locus discovery and enhance information interaction between full-sequence contexts and prioritized regulatory sites via an improved multi-head attention mechanism. Cell phenotype transition tasks are further assessed by uncertainty quantification and confidence calibration. In particular, in gene knockout experiments, we found that knocking out important genes alters the probability of cell phenotype transition and differentiation, and knocking out a certain number of essential genes can terminate specific transition processes. Data, code, and checkpoints are publicly available at https://github.com/Ssupercoder/DualCPT.

AAAI 2026

DualCPT: Dual-branch Modeling for Cellular Phenotype Transition

foundation model;multi-modality learning;information fusion

technical paper

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.<br><br>

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

Multimodal image fusion aims to integrate complementary information from multiple imaging modalities into a single, informative representation, which is crucial for applications in medical imaging and microscopy. Existing methods often face trade-offs between structural fidelity, edge preservation, and computational efficiency. In this work, we propose LightFusionNet, a lightweight dual-stream network designed to efficiently fuse multimodal images while retaining key structural, textural, and intensity features. The network leverages depthwise separable convolutions to reduce model complexity and incorporates a Predictive Context Attention (PCA) mechanism to selectively emphasize informative regions in the feature maps. Extensive experiments on benchmark medical imaging datasets, including PET-MRI, SPECT-MRI, and CT-MRI, demonstrate that our approach achieves comparable qualitative and quantitative performance compared to state-of-the-art fusion methods, while maintaining low computational cost. The proposed method provides an effective and efficient solution for multimodal image fusion, suitable for both clinical and research applications.

LightFusionNet: Lightweight Dual-Stream Network with Predictive Context Attention for Efficient Medical Image Fusion

Models trained on data from one site often underperform at another due to distribution shift, which can impede reliable deployment for medical imaging tasks. We tackle the problem of multi-center healthcare AI, where models must generalize across hospitals with heterogeneous imaging protocols, scanner hardware, and patient demographics. We propose a principled framework based on optimal transport dataset distances (OTDD) to analyze and guide cross‑site transfer. While OT-based approaches have mostly been applied to benchmark, non-medical datasets, we demonstrate its utility in a multi-center healthcare setting. We (i) build OTDD distance matrices between centers from fixed image embeddings (ResNet‑50, ResNet‑18), (ii) cluster centers using OT distance to reveal structure, and (iii) test whether transfer performance (finetuning on a single source, testing on a target) aligns with OTDD. We find that continuous OTDD distances correlate negatively with target AUROC across source-target pairs indicating that centers close in OTDD yield higher AUROC upon finetuning. Our results support OTDD as a center‑level selector/ranker for cross‑site adaptation in multi‑center healthcare, particularly when evaluated with threshold‑free metrics like AUROC.

Multi-Center Domain Shift in Healthcare AI: Optimal Transport-Based Quantification and Adaptation

Mental health challenges and cyberbullying are increasingly prevalent in digital spaces, necessitating scalable and interpretable detection systems. This paper introduces a unified multiclass classification framework for detecting ten distinct mental health and cyberbullying categories from social media data. We curate datasets from Twitter and Reddit, implementing a rigorous ‘split-then-balance’ pipeline to train on balanced data while evaluating on a realistic, held-out imbalanced test set. We conduct a comprehensive evaluation comparing traditional lexical models, hybrid approaches, and several end-to-end fine-tuned transformers. Our results demonstrate that end-to-end fine-tuning is critical for performance, with the domain-adapted MentalBERT emerging as the top model, achieving an accuracy of 0.92 and a Macro F1 score of 0.76, surpassing both its generic counterpart and a zero-shot LLM baseline. Grounded in a comprehensive ethical analysis, we frame the system as a human-in-the-loop screening aid, not a diagnostic tool. To support this, we introduce a hybrid SHAP-LLM explainability framework and present a prototype dashboard (“Social Media Screener”) designed to integrate model predictions and their explanations into a practical workflow for moderators. Our work provides a robust baseline, highlighting future needs for multi-label, clinically validated datasets at the critical intersection of online safety and computational mental health.

A Machine Learning Approach for Detection of Mental Health Conditions and Cyberbullying from Social Media

Accurate and reliable medical image classification is critical for clinical decision-making across diverse imaging modalities, including X-ray, CT, and MRI. Traditional convolutional neural networks often produce overconfident predictions, limiting their clinical trustworthiness. In this work, we propose an uncertainty-aware, attention-augmented neural network that integrates multi-scale SwirlAttention and FeedBackAttention modules with a Bayesian probabilistic classifier. This framework enables robust feature extraction, interpretable attention maps, and principled estimation of epistemic uncertainty. We evaluate our approach on four diverse datasets, including Diabetic Retinopathy, Kvasir, Skin Cancer, and fused multi-focal Oocyte images, covering a wide range of pathological and morphological variations. Extensive experiments demonstrate that our method outperforms state-of-the-art CNN and transformer-based baselines in terms of accuracy, calibration, and interpretability. Grad-CAM visualizations highlight clinically relevant regions, while uncertainty estimates provide actionable insights for ambiguous cases, making the framework suitable for reliable deployment in real-world clinical settings.

BUCAN: Bayesian Uncertainty-aware Classification with Attention Networks for Medical Images

Recent advances in large language models (LLMs) have shown strong reasoning capabilities through large-scale pretraining and post-training reinforcement learning, demonstrated by DeepSeek-R1. However, current post-training methods, such as Grouped Relative Policy Optimization (GRPO), mainly reward correctness, which is not aligned with the multi-dimensional objectives required in high-stakes fields such as medicine, where reasoning must also be faithful and comprehensive. We introduce Clinical-Objective Relative Policy Optimization (CRPO), a scalable, multi-objective, verifiable reinforcement learning method designed to align LLM post-training with clinical reasoning principles. CRPO integrates rule-based and verifiable reward signals that jointly optimize accuracy, faithfulness, and comprehensiveness without relying on human annotation. To demonstrate its effectiveness, we train Clinical-R1-3B, a 3B-parameter model for clinical reasoning. The experiments on three benchmarks demonstrate that our CRPO substantially improves reasoning on truthfulness and completeness over standard GRPO while maintaining comfortable accuracy enhancements. This framework provides a scalable pathway to align LLM reasoning with clinical objectives, enabling safer and more collaborative AI systems for healthcare while also highlighting the potential of multi-objective, verifiable RL methods in post-training scaling of LLMs for medical domains.

Clinical-R1: Empowering Large Language Models for Faithful and Comprehensive Reasoning with Clinical Objective Relative Policy Optimization

Federated learning enables collaborative model development across medical institutions without centralizing sensitive patient data, yet existing embedding-level generative approaches often degrade under non-IID clinical heterogeneity and offer limited formal protection against gradient leakage. We introduce FedHypeVAE, a differentially private, hypernetwork based conditional variational framework that generates client-specific decoders and priors from lightweight, trainable client codes. This bi-level formulation personalizes the generative process while ensuring privacy preserving parameter synthesis decoupled from raw medical images. Federated optimization with differential privacy and distributional alignment strategies improves stability and cross-site generalization. The proposed framework unifies personalization, privacy, and domain adaptability within the generative layer, offering a principled solution for privacy aware representation learning in multi institutional medical imaging.

FedHypeVAE: Federated Learning with Hypernetwork Generated Conditional VAEs for Differentially Private Embedding Sharing

Recent developments on chest radiographs has primarily focused on developing multi-disease frameworks that aim to diagnose a wide range of thoracic abnormalities from the Chest X-ray datasets. In contrast, this study specifically targets pneumothorax, a life-threatening condition commonly referred to as a collapsed lung, which requires timely detection and accurate clinical reporting. Existing automated report generation Vision-Language Models (VLMs) mainly rely on image-level features and often fail to fully leverage the rich structural information embedded in medical image segmentation. To address this limitation, we propose a distinct strategy to incorporate pneumothorax segmentation masks, which delineate affected regions and provide precise localization guidance to enhance the accuracy of medical image interpretation. Experimental results demonstrate that the proposed segmentation-guided approach integrates visual and textual understanding more effectively for pneumothorax diagnosis from chest radiographs. By employing segmentation masks as guidance, VLMs can accurately localize pathological regions while preserving anatomical context, thereby improving both interpretability and diagnostic precision. Quantitative evaluations across multiple metrics further confirm the effectiveness of the proposed methods in bridging the gap between image-level localization and report-level reasoning.

Segmentation-Guided Radiology Report Generation for Pneumothorax Detection in Chest X-Rays

Mammography is one of the primary imaging modalities for breast cancer screening and diagnosis, playing a pivotal role in early detection and mortality reduction. To alleviate the burden on radiologists interpreting mammographic data, artificial intelligence-based models have emerged as decision-making assistants, demonstrating promising results in several studies. However, a critical gap remains between AI capabilities and clinical integration. Current AI systems predominantly employ end-to-end classification approaches that bypass the structured, multi-step reasoning radiologists use in practice. Radiologists systematically detect abnormalities, characterize their features using standardized descriptors, correlate findings across imaging views, perform temporal comparisons, assess information sufficiency, and synthesize evidence into risk-stratified recommendations. In contrast, most AI models map directly from images to diagnoses without transparent intermediate reasoning, limiting their interpretability, clinical utility, and ability to generalize beyond training distributions. This paper examines the radiological chain-of-thought process in mammography interpretation, reviews current AI approaches and their limitations, and proposes a multi-stage reasoning framework that explicitly models each step of clinical decision-making. By decomposing the diagnostic task into sequential reasoning-based stages, this framework aims to create AI systems that not only predict outcomes but also reason transparently in alignment with clinical workflow. Crucially, we explain how contextual information such as breast density serves as a conditioning variable that dynamically optimizes subsequent reasoning stages, mirroring the adaptive decision-making process radiologists employ in clinical practice. We discuss the implications of this approach and identify critical dataset limitations that must be addressed to enable the development of truly reasoning-aware AI in breast imaging.

The Need to Move Beyond Explainability Toward Chain-of-Thought Reasoning: A Focus on AI for Mammography

Clinical ultrasound acquisition is highly operator-dependent, where rapid probe motion and brightness fluctuations often lead to reconstruction errors that reduce trust and clinical utility. We present UltrasODM, a dual-stream framework that assists sonographers during acquisition through calibrated per-frame uncertainty, saliency-based diagnostics, and actionable prompts. UltrasODM integrates (i) a contrastive ranking module that groups frames by motion similarity, (ii) an optical-flow stream fused with Dual Mamba temporal modules for robust 6-DoF pose estimation, and (iii) a Human-in-the-Loop (HITL) layer combining Bayesian uncertainty, clinician-calibrated thresholds, and saliency maps highlighting regions of low confidence. When uncertainty exceeds the threshold, the system issues unobtrusive alerts suggesting corrective actions such as re-scanning highlighted regions or slowing the sweep. Evaluated on a clinical freehand ultrasound dataset, UltrasODM reduces drift by 15.2%, distance error by 12.1%, and Hausdorff distance by 10.1% relative to UltrasOM, while producing per-frame uncertainty and saliency outputs. By emphasizing transparency and clinician feedback, UltrasODM improves reconstruction reliability and supports safer, more trustworthy clinical workflows.

UltrasODM: A Dual Stream Optical Flow Mamba Network for 3D Freehand Ultrasound Reconstruction

The rise in clinical AI has helped to define the diagnostic and decision-making process in the dimension of modern medicine. However, their implementation is constrained by multiple ethical, interpretability, and safety factors that hinder the effective utilization of these AI systems. Existing Human-in-the-Loop (HITL) systems rely heavily on externally triggered human oversight, which creates critical gaps in effective safety and accountability. This study introduces the AI-Instigated Human Oversight (AIHO) framework, an AI governance architecture that enables models to self-assess uncertainty or contextual failure and autonomously escalate decisions to human oversight through a four-layer detection and escalation mechanism. Each layer performs a distinct self-assessment: (Layer 1) predictive uncertainty quantification, (Layer 2) contextual validation and explainability, (Layer 3) ethical and proxy alignment monitoring, and (Layer 4) adaptive governance with human-in-command enforcement. These layers form part of a three-zone operational architecture: (1) Information Flow and AI Core Processing, (2) AIHO Oversight Core, and (3) Human Escalation Loops. These zones in conjunction create a continuous feedback loop which administers continuous self-evaluation, transforming ethical and technical anomalies into actionable human oversight triggers. AIHO establishes a dynamic pathway toward regulation-ready, self-aware clinical AI, aligning with the current international standards for trustworthy and accountable AI in medicine.

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LightFusionNet: Lightweight Dual-Stream Network with Predictive Context Attention for Efficient Medical Image Fusion

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LightFusionNet: Lightweight Dual-Stream Network with Predictive Context Attention for Efficient Medical Image Fusion

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