The multi-agent path finding (MAPF) problem asks to find a set of paths on a graph such that when synchronously following these paths the agents never encounter a conflict. In the most widespread MAPF formulation, the so-called Classical MAPF, the agents’ sizes are neglected and two types of conflicts are considered: occupying the same vertex or using the same edge at the same time step. Meanwhile in numerous practical applications, e.g. in robotics, taking into account the agents’ sizes is vital to ensure that the MAPF solutions can be safely executed. Introducing large agents yields an additional type of conflict arising when one agent follows an edge and its body overlaps with the body of another agent that is actually not using this same edge (e.g. staying still at some distinct vertex of the graph). Until now it was not clear how harder the problem gets when such conflicts are to be considered while planning. Specifically, it was known that Classical MAPF problem on an undirected graph can be solved in polynomial time, however no complete polynomial-time algorithm was presented to solve MAPF with large agents. In this paper we, for the first time, establish that the latter problem is NP-hard and, thus, if P≠NP no polynomial algorithm for it can, unfortunately, be presented. Our proof is based on the prevalent in the field technique of reducing the seminal 3-SAT problem (which is known to be an NP-complete problem) to the problem at hand. In particular, for an arbitrary 3-SAT formula we procedurally construct a dedicated graph with specific start and goal vertices and show that the given 3-SAT formula is satisfiable iff the corresponding path finding instance has a solution.