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Medical image synthesis is an important topic for both clinical and research applications. Recently, diffusion models have become a leading approach in this area. Despite their strengths, many existing methods struggle with (1) limited generalizability, only working for specific body regions or voxel spacings, (2) slow inference, which is a common issue for diffusion models, and (3) weak alignment with input conditions, which is a critical issue for medical imaging. MAISI, a previously proposed framework, addresses generalizability issues but still suffers from slow inference and limited condition consistency. In this work, we present MAISI-v2, the first accelerated 3D medical image synthesis framework that integrates rectified flow to enable fast and high-quality generation. To further enhance condition fidelity, we introduce a novel region-specific contrastive loss to improve sensitivity to the region of interest. Our experiments show that MAISI-v2 can achieve state-of-the-art image quality with 33× acceleration for latent diffusion models. We also conducted a downstream segmentation experiment to show that the synthetic images can be used for data augmentation. We release our code, training details, model weights, and a GUI demo to facilitate reproducibility and promote further development within the community.

AAAI 2026

MAISI-v2: Accelerated 3D High-Resolution Medical Image Synthesis with Rectified Flow and Region-specific Contrastive Loss

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.<br><br>

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

While conventional computer vision emphasizes pixel-level and feature-based objectives, medical image analysis of intricate biological structures necessitates explicit representation of their complex topological properties. Despite their successes, deep learning models often struggle to accurately capture the connectivity and continuity of fine, sometimes pixel-thin, yet critical structures due to their reliance on implicit learning from data. To address this challenge, we introduce Conformable Convolution, a novel convolutional layer designed to explicitly impose topological consistency. Conformable Convolution learns adaptive kernel offsets that focus on regions of high topological significance within an image. This prioritization is guided by our proposed Topological Posterior Generator (TPG) module, which leverages persistent homology. The TPG module identifies key topological features and guides the convolutional layers by applying persistent homology to feature maps transformed into cubical complexes. Unlike existing approaches that are merely aware of topology, our method explicitly constrains the learning process to ensure topological correctness. The proposed modules are architecture-agnostic, enabling them to be integrated seamlessly into various architectures. We showcase the effectiveness of our framework in the segmentation task, where preserving the interconnectedness of structures is critical. The results on three diverse datasets demonstrate that our framework effectively preserves the topology both quantitatively and qualitatively. The source code of this work will be published upon its acceptance.

Conformable Convolution for Topologically Constrained Learning of Complex Anatomical Structures

As synthetic data proliferates across the Internet, it is often reused to train successive generations of generative models. This creates a "self-consuming loop" that can lead to training instability or *model collapse*. Common strategies to address the issue---such as accumulating historical training data or injecting fresh real data---either increase computational cost or require expensive human annotation. In this paper, we empirically analyze the latent space dynamics of self-consuming diffusion models and observe that the low-dimensional structure of latent representations extracted from synthetic data degrade over generations. Based on this insight, we propose *Latent Space Filtering* (LSF), a novel approach that mitigates model collapse by filtering out less realistic synthetic data from mixed datasets. Theoretically, we present a framework that connects latent space degradation to empirical observations. Experimentally, we show that LSF consistently outperforms existing baselines across multiple real-world datasets, effectively mitigating model collapse without increasing training cost or relying on human annotation.

Stabilizing Self-Consuming Diffusion Models with Latent Space Filtering

Adversarial text attacks remain a persistent threat to transformer models, yet existing defenses are typically attack-specific or require costly model retraining. We introduce Guided Perturbation Sensitivity (GPS), a model-agnostic detection framework that identifies adversarial examples by measuring how embedding representations change when important words are masked. GPS first ranks words using importance heuristics, then measures embedding sensitivity to masking top-$k$ critical words, and processes the resulting patterns with a BiLSTM detector. Experiments show that adversarially perturbed words exhibit disproportionately high masking sensitivity compared to naturally important words. Across three datasets, three attack types, and two victim models, GPS achieves over 88\% detection accuracy and demonstrates competitive performance compared to existing state-of-the-art methods, often at lower computational cost. Using Normalized Discounted Cumulative Gain (NDCG) to measure perturbation identification quality, we demonstrate that gradient-based ranking significantly outperforms attention and random selection approaches, with identification quality strongly correlating with detection performance for word-level attacks ($\rho = 0.65$). GPS also generalizes well to unseen datasets, attacks, and models without retraining, providing a practical solution for adversarial text detection.

Guided Perturbation Sensitivity (GPS): Detecting Adversarial Text via Embedding Stability and Word Importance

Custom Diffusion Models (CDMs) offer impressive capabilities for personalization in generative modeling, yet they remain vulnerable to catastrophic forgetting when learning new concepts sequentially. Existing approaches primarily focus on minimizing interference between concepts, often neglecting the potential for positive inter-concept interactions. In this work, we present FLLP (Forget Less by Learning from Parent), a novel framework that introduces a parent-child inter-concept learning mechanism in hyperbolic space to mitigate forgetting. By embedding concept representations within a Lorentzian manifold, naturally suited for modeling tree-like hierarchies, we define parent-child relationships where previously learned concepts act as guidance for adapting to new ones. Our method not only preserves prior knowledge but also supports continual integration of new concepts. We validate FLLP on three public datasets and one synthetic benchmark, showing consistent improvements in both robustness and generalization.

Forget Less by Learning from Parents Through Hierarchical Relationships

Despite significant advancements in point cloud analysis, reducing energy consumption and improving robustness remain understudied, largely due to the inherent limitations of Convolutional Neural Networks (CNNs). To address this, we take the cue from the primary visual cortex and propose a Dendritic-Connected Continuous-Coupled Neural Network (DC-CCNN), a novel Brain-Inspired Neural Network (BINN) architecture tailored for point cloud analysis. By leveraging the unique characteristics of point clouds, our design combines discrete and continuous encoding, replacing traditional Multilayer Perceptrons (MLPs) with more efficient and robust BINNs. Our approach substantially improves the performance of Brain-Inspired Neural Networks on point analysis tasks and maintaining performance comparable to state-of-the-art methods. Furthermore, DC-CCNN exhibits enhanced robustness against various point cloud deformations and corruptions. Our experimental results demonstrate that DC-CCNN achieves competitive performance on benchmark datasets, making it a promising alternative to traditional deep learning methods for point cloud analysis. With its high efficiency and robustness, DC-CCNN has the potential for widespread adoption in 3D computer vision, robotics, and autonomous systems.

Primary Visual Cortex Inspired Point Cloud Analysis Framework

Large Language Models (LLMs) have greatly advanced knowledge graph question answering (KGQA), yet existing systems are typically optimized for returning highly relevant but predictable answers.
A missing yet desired capacity is to exploit LLMs to suggest surprise and novel (``serendipitious'') answers.
In this paper, we formally define the serendipity-aware KGQA task and propose the SerenQA framework to evaluate LLMs' ability to uncover unexpected insights in scientific KGQA tasks. 
SerenQA includes a rigorous serendipity metric based on relevance, novelty, and surprise, along with an expert-annotated benchmark derived from the Clinical Knowledge Graph, focused on drug repurposing. 
Additionally, it features a structured evaluation pipeline encompassing three subtasks: knowledge retrieval, subgraph reasoning, and serendipity exploration.
Our experiments reveal that while state-of-the-art LLMs perform well on retrieval, they still struggle with identifying genuinely surprising and valuable discoveries, underscoring significant room for future improvements.
Our curated resources have been released as supplementary material.

Assessing LLMs for Serendipity Discovery in Knowledge Graphs: A Case for Drug Repurposing

Deploying Large Language Models (LLMs) in specialized domains introduces significant societal and compliance risks, including bias amplification, misinformation propagation, and privacy violations. These risks predominantly emerge from the dynamic interactions between LLMs and humans in specific contexts. Different domains face unique distribution of hazards, and varying interaction modalities introduce distinct levels of exposure and vulnerability. However, current risk assessment frameworks lack a systematic methodology to capture this dynamic interplay. In this work, we introduce the HEV Generative Sandbox, a novel risk evaluation framework that simulates human-LLM behavior to quantify domain-contextual risks across three interdependent dimensions: 1) Hazard (H): Domain-specific threats inherent to a given context; 2) Exposure (E): The extent to which the LLM and its users are subjected to hazardous scenarios; 3) Vulnerability (V): The susceptibility of the system to risk due to human interaction or model weaknesses. Our approach pioneers "domain-rooted scenario generation", wherein we sample contextual distributions from domain-specific corpora and simulate diverse inputs. By unifying dynamic scenario simulation, causal risk decomposition, and closed-loop evaluation, the HEV Generative Sandbox provides a scalable, domain-sensitive methodology for responsible LLM deployment. This work contributes to advancing the safe deployment of LLMs by providing a comprehensive and automated risk evaluation framework. We plan to make our code and simulation-generated data publicly available upon publication.

HEV Generative Sandbox: A Framework for Assessing Domain-Specific Social Risks Through Human-LLM Simulation

In cooperative Multi-Agent Reinforcement Learning (MARL), efficient exploration is crucial for optimizing the performance of joint policy. However, existing methods often update joint policies via independent agent exploration, without coordination among agents, which inherently constrains the expressive capacity and exploration of joint policies. To address this issue, we propose a conductor-based joint policy framework that directly enhances the expressive capacity of joint policies and coordinates exploration. In addition, we develop a Hierarchical Conductor-based Policy Optimization (HCPO) algorithm that instructs policy updates for the conductor and agents in a direction aligned with performance improvement. A rigorous theoretical guarantee further establishes the monotonicity of the joint policy optimization process. By deploying local conductors, HCPO retains centralized training benefits while eliminating inter-agent communication during execution. Finally, we evaluate HCPO on three challenging benchmarks: StarCraftII Multi-agent Challenge, Multi-agent MuJoCo, and Multi-agent Particle Environment. The results indicate that HCPO outperforms competitive MARL baselines regarding cooperative efficiency and stability.

HCPO: Hierarchical Conductor-Based Policy Optimization in Multi-Agent Reinforcement Learning

Test-time compute scaling has emerged as a powerful paradigm for enhancing mathematical reasoning in large language models (LLMs) by allocating additional computational resources during inference. However, current methods employ uniform resource distribution across all reasoning sub-problems, creating fundamental bottlenecks where challenging sub-problems receive insufficient attention while routine operations consume disproportionate resources. This uniform allocation creates performance bottlenecks where additional computational resources yield diminishing returns. Inspired by dual-process theory, we propose **SCALE** (Selective Resource Allocation), a framework that selectively allocates computational resources based on sub-problem difficulty. SCALE operates through four stages: (1) problem decomposition into sequential reasoning sub-problems, (2) difficulty assessment of each sub-problem to distinguish between routine operations and computationally challenging sub-problems, (3) selective processing mode assignment between System 1 for simple sub-problems and System 2 for complex ones, and (4) sequential execution with context propagation. By concentrating resources on challenging sub-problems while processing routine operations efficiently, SCALE achieves substantial performance improvements with superior resource utilization. Extensive experiments demonstrate that SCALE significantly outperforms uniform scaling baselines, achieving accuracy improvements of up to 13.75 percentage points (57.50\% to 71.25\% on AIME25) while reducing computational costs by 33-53\%, representing a major advance in test-time scaling that addresses fundamental limitations of current approaches.

SCALE: Selective Resource Allocation for Overcoming Performance Bottlenecks in Mathematical Test-time Scaling

High-quality training data is critical to the performance of large language models (LLMs). Recent work has explored using LLMs to rate and select data based on a small set of human-designed criteria (rules), but these approaches often rely heavily on heuristics, lack principled metrics for rule evaluation, and generalize poorly to new tasks. We propose a novel rule-based data selection framework that introduces a metric based on the orthogonality of rule score vectors to evaluate and select complementary rules. Our automated pipeline first uses LLMs to generate diverse rules covering multiple aspects of data quality, then rates samples according to these rules and applies the determinantal point process (DPP) to select the most independent rules. These rules are then used to score the full dataset, and high-scoring samples are selected for downstream tasks such as LLM fine-tuning. We evaluate our framework in two experiment setups: (1) alignment with ground-truth ratings and (2) performance of LLMs fine-tuned on the selected data. Experiments across IMDB, Medical, Math, and Code domains demonstrate that our DPP-based rule selection consistently improves both rating accuracy and downstream model performance over strong baselines.

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Conformable Convolution for Topologically Constrained Learning of Complex Anatomical Structures

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