Singapore

Sparse Autoencoder (SAE) has emerged as a powerful tool for mechanistic interpretability of large language models. Recent works apply SAE to protein language models (PLMs), aiming to extract and analyze biologically meaningful features from their latent spaces. However, SAE suffers from semantic entanglement, where individual neurons often mix multiple nonlinear concepts, making it difficult to reliably interpret or manipulate model behaviors. In this paper, we propose a semantically-guided SAE, called ProtSAE. Unlike existing SAE which requires annotation datasets to filter and interpret activations, we guide semantic disentanglement during training using both annotation datasets and domain knowledge to mitigate the effects of entangled attributes. We design interpretability experiments showing that ProtSAE learns more biologically relevant and interpretable hidden features compared to previous methods. Performance analyses further demonstrate that ProtSAE maintains high reconstruction fidelity while achieving better results in interpretable probing. We also show the potential of ProtSAE in steering PLMs for downstream generation tasks.

AAAI 2026

ProtSAE: Disentangling and Interpreting Protein Language Models via Semantically-Guided Sparse Autoencoders

sparse autoencoder

protein language model

mechanistic interpretability

## Welcome!
"I am excited to welcome you to this year’s edition of the Conference on Empirical Methods in Natural Language Processing! Importantly, it marks the 30th edition of EMNLP. With over 8,000 submissions, more than 3,000 accepted papers, and thousands of attendees, we have come a long way from that first
workshop, which had 14 accepted papers. As the field looks ahead, Suzhou is the fitting location for celebrating this milestone: rooted in a long literary tradition, yet modern and forward-looking, and home to a large share of the NLP community." 

*Message from the General Chair, Dirk Hovy*

EMNLP 2025

Celebrate 30 Years of EMNLP! 
EMNLP 2025 will be held in Suzhou, China from November 5th to November 9th, 2025.

poster

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

To access this event page, you need to log in with the **email address you registered with**. Access credentials will be sent to your email from Underline - subject line "Welcome to AAAI 2026". Please be sure to check your spam email folder if you do not see an email confirmation right away.

Please log in

To access this event page, you are required to register.
Please complete your registration to continue.

We recommend reading [**the registration information**](https://aaai.org/conference/aaai/aaai-26/registration/) first.

**Online Registration Form**: https://aaai.getregistered.net/conference-2026 

Registration Required

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

Despite significant advancements in general AI, its effectiveness in the medical domain is limited by the lack of specialized medical knowledge. 
To address this, we formulate GMAI-VL-5.5M, a multimodal medical dataset created by converting hundreds of specialized medical datasets with various annotations into high-quality image-text pairs. 
This dataset offers comprehensive task coverage, diverse modalities, and rich image-text data. 
Building upon this dataset, we develop GMAI-VL, a general medical vision-language model, with a three-stage training strategy that enhances the integration of visual and textual information. 
This approach significantly improves the model's ability to process multimodal data, supporting accurate diagnoses and clinical decision-making. 
Experiments show that GMAI-VL achieves state-of-the-art performance across various multimodal medical tasks, including visual question answering and medical image diagnosis.

GMAI-VL & GMAI-VL-5.5M: A Large Vision-Language Model and a Comprehensive Multimodal Dataset Towards General Medical AI

Large language models have led to significant progress across many NLP tasks, although their massive sizes often incur substantial computational costs. Distillation has become a common practice to compress these large and highly capable models into smaller, more efficient ones. Many existing language model distillation methods can be viewed as behavior cloning from the perspective of imitation learning or inverse reinforcement learning. This viewpoint has inspired subsequent studies that leverage (inverse) reinforcement learning techniques, including variations of behavior cloning and temporal difference learning methods. Rather than proposing yet another specific temporal difference method, we introduce a general framework for temporal difference-based distillation by exploiting the distributional sparsity of the teacher model. Specifically, it is often observed that language models assign most probability mass to a small subset of tokens. Motivated by this observation, we design a temporal difference learning framework that operates on a reduced action space (a subset of vocabulary), and demonstrate how practical algorithms can be derived and the resulting performance improvements.

Language Model Distillation: A Temporal Difference Imitation Learning Perspective

3D visual grounding (3DVG) identifies objects in 3D scenes from language descriptions, with applications in augmented reality and embodied AI. Existing zero-shot approaches leverage 2D vision–language models (VLMs) by converting 3D spatial information (SI) into forms amenable to VLM processing, typically as composite visual inputs such as specified-view renderings or video sequences with overlaid object markers. However, this VLM~$\oplus$~SI paradigm yields entangled visual representations that compel the VLM to process entire cluttered cues, making it hard to exploit spatial–semantic relationships effectively.
In this work, we propose a new VLM~$\otimes$~SI paradigm that externalizes the 3D SI into a form that enables the VLM to incrementally retrieve only what it needs during its reasoning process.
We instantiate this paradigm with a novel View-on-Graph (VoG) method, which organizes the scene into a multi-modal, multi-layer scene graph and allows the VLM to operate as an active agent that selectively accesses necessary cues as it traverses the scene. This design offers two intrinsic advantages:
(i) by structuring 3D context into a spatially and semantically coherent scene graph rather than confounding the VLM with densely entangled visual inputs, it makes spatial–semantic relationships easier to exploit and lowers the VLM's reasoning difficulty; and
(ii) by actively exploring and reasoning over the scene graph, it naturally produces transparent, step-by-step traces for interpretable 3DVG.
Extensive experiments demonstrate the effectiveness of the proposed VLM~$\otimes$~SI paradigm and show that VoG achieves state-of-the-art zero-shot performance, establishing structured scene exploration as a promising strategy for advancing zero-shot 3DVG.

View-on-Graph: Zero-Shot 3D Visual Grounding via Vision-Language Reasoning on Scene Graphs

Resource-constrained weight deployment is a task of immense practical importance. Recently, there has been interest in the specific task of Delta Compression, where parties each hold a common base model and only communicate compressed weight updates. However, popular parameter efficient updates such as Low Rank Adaptation (LoRA) face inherent representation limitations - which are especially pronounced when combined with aggressive quantization. To overcome this, we build on recent work that improves LoRA representation capacity by using fixed-frequency sinusoidal functions to increase stable rank without adding additional parameters. We extend this to the quantized setting and present the first theoretical analysis showing how stable rank evolves under quantization. From this, we introduce SineLoRA$\Delta$, a principled and effective method for delta compression that improves the expressivity of quantized low-rank adapters by applying a sinusoidal activation. We validate SineLoRA$\Delta$ across a diverse variety of domains - including language modeling, vision-language tasks, and text-to-image generation - achieving up to 66\% memory reduction with similar performance. We additionally provide a novel application of the canonical Bjøntegaard Delta metric to consistently compare adapter compression changes across the rate-distortion curve.

SineLoRA∆: Sine-Activated Delta Compression

Traditionally, AI research in medical diagnosis has largely centered on image analysis. While this has led to notable advancements, the absence of patient-reported symptoms continues to hinder diagnostic accuracy. To address this, we propose a Pre-Consultation Dialogue framework that mimics real-world diagnostic procedures, where doctors iteratively query patients before reaching a conclusion. Specifically, we simulate diagnostic dialogues between two vision–language models (VLMs): a DoctorVLM, which generates follow-up questions based on the image and dialogue history, and a PatientVLM, which responds using a symptom profile derived from the ground-truth diagnosis. We additionally conducted a small-scale clinical validation of the synthetic symptoms generated by our framework, confirming their usefulness for diagnosis. These DocVLM–PatientVLM interactions yield realistic, multi-turn dialogues paired with images and diagnoses, which are then used to fine-tune the DoctorVLM. This dialogue-based training substantially enhances diagnostic performance. For instance, using Qwen2.5-VL-7B as the base model, with symptoms generated using our framework achieves an F1 score of 81.0%, compared to just 56.5% with direct image-only fine-tuning on the DermaMNIST dataset.

PatientVLM Meets DocVLM: Pre-Consultation Dialogue Between Vision-Language Models for Efficient Diagnosis

Long-term, high-fidelity simulation of slow-changing physical systems, such as the ocean and climate, presents a fundamental challenge in scientific computing. Traditional autoregressive machine learning models often fail in these tasks as minor errors accumulate and lead to rapid forecast degradation. To address this problem, we propose NeuralOM, a general neural operator framework designed for simulating complex, slow-changing dynamics. NeuralOM's core consists of two key innovations: (1) a Progressive Residual Correction Framework that decomposes the forecasting task into a series of fine-grained refinement steps, effectively suppressing long-term error accumulation; and (2) a Physics-Guided Graph Network whose built-in adaptive messaging mechanism explicitly models multi-scale physical interactions, such as gradient-driven flows and multiplicative couplings, thereby enhancing physical consistency while maintaining computational efficiency. We validate NeuralOM on the challenging task of global Subseasonal-to-Seasonal (S2S) ocean simulation. Extensive experiments demonstrate that NeuralOM not only surpasses state-of-the-art models in forecast accuracy and long-term stability, but also excels in simulating extreme events. For instance, at a 60-day lead time, NeuralOM achieves a 13.3% lower RMSE compared to the best-performing baseline, offering a stable, efficient, and physically-aware paradigm for data-driven scientific computing.

NeuralOM: Neural Ocean Model for Subseasonal-to-Seasonal Simulation

Despite recent advances in LLMs, the task of code generation is still challenging. To cope, code selection algorithms select the best program from multiple programs generated by an LLM. However, existing algorithms can fail to identify the correct program, either because they can misidentify nonequivalent programs or because they rely on an LLM and assume it always correctly determines the output for every input. We present ExPairT-LLM, an exact learning algorithm for code selection that selects a program by posing to an LLM oracle two new types of queries: pairwise membership and pairwise equivalence. These queries are simpler for LLMs and enable ExPairT-LLM to identify the correct program through a tournament, which is robust to some LLM mistakes. We evaluate ExPairT-LLM on four popular code datasets. Its pass@1 (success rate) outperforms the state-of-the-art code selection algorithm on average by +13.0% and up to +27.1%. It also improves the pass@1 of LLMs performing complex reasoning by +24.0%.

ExPairT-LLM: Exact Learning for LLM Code Selection by Pairwise Queries

Sequential recommendation aims to predict the next item based on historical interactions. To further enhance the reasoning capability in sequential recommendation, LLMs are employed to predict the next item or generate semantic IDs for item representation, given LLMs' extensive domain knowledge and reasoning ability. However, existing LLM-based methods suffer from two limitations. (i) The scarcity of recommendation data with reasoning paths makes it challenging to design suitable chain-of-thought prompting templates, and the full potential of LLMs' reasoning abilities remains underutilized. (ii) Upon obtaining semantic IDs, the LLMs and their representations are excluded from the subsequent recommendation model training, preventing downstream models from fully utilizing the rich semantic information encoded within these IDs. To address these issues, we propose a novel CoderRec framework, which is capable of fully exploiting the information encoded in semantic IDs to guide the recommendation process. Specifically, to address the problem of scarcity in reasoning path-augmented data, we introduce latent reasoning into sequential recommendation and treat the representation captured by the downstream model as domain-specific latent thought, enabling implicit logical inference without requiring explicit CoT annotations. To ensure that the downstream recommendation models are able to deeply leverage the semantic information within IDs, we propose a novel cross-scale model collaboration strategy, which employs cross-scale IDs and a two-phase approach to align LLM-derived semantics with recommendation objectives. Extensive experiments have shown the effectiveness of our proposed CoderRec framework.

Cross-Scale Collaboration between LLMs and Lightweight Sequential Recommenders with Domain-Specific Latent Reasoning

Causal discovery from observational data is a fundamental tool in various fields of science.
While existing approaches are typically designed for a single dataset, we often need to handle multiple datasets with non-identical variable sets in practice.
One straightforward approach is to estimate a causal graph from each dataset and construct a single causal graph by overlapping.
However, this approach identifies limited causal relationships because unobserved variables in each dataset can be confounders, and some variable pairs may be unobserved in any dataset.
To address this issue, we leverage Causal Additive Models with Unobserved Variables (CAM-UV) that provide causal graphs having information related to unobserved variables.
We show that the ground truth causal graph has structural consistency with the information of CAM-UV on each dataset.
As a result, we propose an approach named I-CAM-UV to integrate CAM-UV results by enumerating all consistent causal graphs.
We also provide an efficient combinatorial search algorithm and demonstrate the usefulness of I-CAM-UV against existing methods.

I-CAM-UV: Integrating Causal Graphs over Non-Identical Variable Sets Using Causal Additive Models with Unobserved Variables

While code large language models have demonstrated remarkable progress in code generation, the generated code often exhibits poor runtime efficiency, limiting its practical application in performance-sensitive scenarios. To address this limitation, we propose an efficiency-oriented reinforcement learning framework guided by a novel performance reward. Based on this framework, we take a deeper dive into the code efficiency problem, identifying then proposing methods to overcome key bottlenecks: (1) Dynamic exploration overcomes the static data constraints of offline fine-tuning, enabling the discovery of more efficient code implementations. (2) The error-insensitive reinforcement learning method and high-contrast efficiency signals are crucial for mitigating systematic errors and achieving effective optimization. (3) Online exploration is most effective when starting from a high-correctness baseline, as this allows for efficiency improvements without sacrificing accuracy. With these discoveries, we finally propose a two-stage tuning method, which achieves high and balanced performance across correctness and efficiency. The results of experiments show the effectiveness of the method, which improves code correctness by 10.18\% and runtime efficiency by 7.75\% on a 7B model, achieving performance comparable to much larger model.

Downloads

Next from AAAI 2026

GMAI-VL & GMAI-VL-5.5M: A Large Vision-Language Model and a Comprehensive Multimodal Dataset Towards General Medical AI

Similar lecture

Sparse Autoencoder Features for Classifications and Transferability

Stay up to date with the latest Underline news!

PRESENTATIONS

CONFERENCES

COMPANY

RESOURCES

.css-70qvj9{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-align-items:center;-webkit-box-align:center;-ms-flex-align:center;align-items:center;}Downloads

Next from AAAI 2026

GMAI-VL & GMAI-VL-5.5M: A Large Vision-Language Model and a Comprehensive Multimodal Dataset Towards General Medical AI

Similar lecture

Sparse Autoencoder Features for Classifications and Transferability

Stay up to date with the latest Underline news!

PRESENTATIONS

CONFERENCES

COMPANY

RESOURCES

Downloads