Super-resolution from a Blurry low-resolution image (SRB) constitutes a severely ill-posed inverse problem. Current learning-based SRB approaches primarily rely on synthetic, well-labeled paired datasets to regularize solution spaces, yet they exhibit limited generalizability in practical applications due to significant domain discrepancies between simulated degradations and real-world imaging conditions. To bridge this synthetic-to-real gap, we propose a novel {\it S}elf-supervised {\it E}vent-based SRB (SE-SRB) framework that leverages neuromorphic event streams as physical priors and adopts a lightweight neural architecture tailored for effective domain adaptation. Specifically, the proposed SE-SRB introduces a self-supervised learning paradigm based on asymmetric integral driven consistency, which enforces temporal coherence between predictions derived from RGB and asynchronous event streams at different time points. This constraint encourages the model to implicitly learn the fusion of complementary modalities and reconstruct sharp high-resolution images in accordance with underlying physics patterns. Extensive experiments validate that SE-SRB consistently outperforms state-of-the-art methods on both synthetic and real-world datasets. Notably, all modules are implemented using lightweight neural architectures and are jointly optimized, resulting in high computational efficiency with fewer parameters, reduced FLOPs, and real-time inference capability (40 FPS).