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Recent advances in multi-instance learning (MIL) have demonstrated impressive performance in whole slide image (WSI) analysis. However, current methods search for cues and draw conclusions from all instances or regions, resulting in excessive redundant computation and suboptimal representation quality due to irrelevant and uninformative feature interference. To address these issues, we propose CICS, an efficient and general framework that performs compact information compression and selection for high-efficiency WSI analysis. In particular, CICS features two key components: (1) context-aware compression (CAC), which partitions the instance space into sub-regions and applies learnable compression to discard irrelevant components, reduce computational complexity while facilitating information selection, and (2) global-proximity selective attention (GPSA), which cherry-picks the most informative representation with a proximity-assisted global dynamic selection strategy. Building upon these innovations, CICS forms a plug-and-play module that reduces computational complexity through compact instance representations while improving feature quality by preserving the most informative cues. Extensive experiments on six WSI classification and survival prediction datasets show that CICS consistently improves the performance of multiple representative MIL methods. It achieves 2.5%, 7.7%, and 3.9% accuracy gain over the state-of-the-art Transformer-based TransMIL, Mamba-based MambaMIL, and graph-based WIKG methods on the ESCA dataset.

AAAI 2026

Content-aware Information Compression and Selection for Whole Slide Image Analysis

cv:applications

cv: representation learning for vision

ml: classification and regression

We are pleased to announce the Thirty-Eighth AAAI Conference on Artificial Intelligence (AAAI-24), which will be held in Vancouver, British Columbia at the Vancouver Convention Centre – West Building from 20-27 February, 2024.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-24 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

We expect for AAAI-24 to be an in-person conference – one author of all accepted papers will be expected to present work in person unless there are exceptional circumstances that prevent this.

In order to access the AAAI-24 event page you need to register [here](https://aaai.org/aaai-conference/registration/)

AAAI 2024

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. 

poster

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

Large Language Models (LLMs) exhibit strong performance across various natural language processing (NLP) tasks but remain vulnerable to hallucinations, generating factually incorrect or misleading outputs. Uncertainty estimation, often using predictive entropy estimation, is key to addressing this issue. However, existing methods often require multiple samples or extra computation to assess semantic entropy. This paper proposes an efficient, training-free uncertainty estimation method that approximates predictive entropy using the responses' top-$K$ probabilities. Moreover, we employ an adaptive mechanism to determine $K$ to enhance flexibility and filter out low-confidence probabilities. Experimental results on three free-form question-answering datasets across several LLMs demonstrate that our method outperforms expensive state-of-the-art baselines, contributing to the broader goal of enhancing LLM trustworthiness.

Probabilities Are All You Need: A Probability-Only Approach to Uncertainty Estimation in Large Language Models

Peptide-based drug design targeting “undruggable” proteins remains one of the most critical challenges in modern drug discovery. Conventional peptide-discovery pipelines rely on low-throughput experimental screening, which is both time-consuming and prohibitively expensive. Moreover, existing computational approaches for designing peptides against target proteins typically depend on the availability of high-quality structural information. Although recent structure-prediction tools such as AlphaFold3 have achieved breakthroughs in protein modeling, their accuracy for functional interfaces remains limited. The acquisition of high-resolution structures is often expensive, time-intensive, and particularly challenging for targets with dynamic conformations, further restricting the efficient development of peptide therapeutics. Additionally, current sequence-based generative methods follow a paradigm that relies on known templates, which limits the exploration of sequence space and results in generated peptides lacking diversity and novelty. To address these limitations, we propose a contrastive conditioned diffusion framework for target-specific peptide generation, referred to as PepCCD. It employs a contrastive learning strategy between proteins and peptides to extract sequence-based conditioning representations of target proteins, which serve as precise conditions to guide a pre-trained diffusion model to generate peptide sequences with the desired target specificity. Extensive experiments on multiple benchmark target proteins demonstrate that the peptides designed by PepCCD exhibit strong binding affinity and outperform state-of-the-art methods in terms of diversity and generation efficiency.

PepCCD: A Contrastive Conditioned Diffusion Framework for Target-Specific Peptide Generation

Multimodal sarcasm detection (MSD) aims to identify sarcasm polarity through diverse modalities (i.e., image-text pairs), which gains increasing attention. While significant advancements have been witnessed, the existing approaches still face two major issues: lack of explainability and weak generalizability. In this paper, we introduce a new large vision-language model (LVLM) dubbed S³-MSD for explainable and generalizable MSD through three key components. For explainability, we develop (1) a self-training paradigm bootstrapping answers with explanations automatically, and (2) a self-calibrating mechanism rectifying flawed explanations. For generalizability, we design (3) a self-focusing module amplifying visual semantic entities through preference optimization, to mitigate textual over-reliance. Experimental results on both in-distribution and out-of-distribution (OOD) benchmarks demonstrate that S³-MSD consistently outperforms state-of-the-art methods in detection performance. Furthermore, the proposed S³-MSD provides persuasive explanations, as validated by quantitative and human evaluations.

S³-MSD: Large Vision-Language Model for Explainable and Generalizable Multi-modal Sarcasm Detection

The AI community has shown substantial interest in the concept of world models: internal representations that simulate aspects of the external world, track entities and states, capture causal relationships, and enable prediction of consequences. This contrasts with representations based solely on statistical correlations. A key motivation behind this research direction is the argument that humans possess such mental world models, and finding evidence of similar representations in AI models might indicate that these models truly "understand" the world in a human-like way. In this paper, we use problems and case studies from the philosophy of science literature to critically examine whether the world model framework adequately characterizes human-level understanding. We focus on specific philosophical analyses where the distinction between world model capabilities and human understanding is most pronounced. While these represent particular views of understanding rather than universal definitions, they illuminate some important limitations in using world models as a lens to claim that AI models understand in a human-like way. By highlighting these distinctions, we hope to stimulate deeper discussion about the nature of understanding in both human and artificial contexts.

Beyond World Models: Rethinking Understanding in AI Models

Advanced text generation is paramount for enhancing the naturalness of human-computer interaction and improving emotional expressiveness. Current mainstream methods largely rely on large language models (LLMs) for single-turn generation, often lacking the interactivity and multi-dimensional feedback mechanisms inherent in human writing. This limitation frequently results in generated texts that fall short in terms of depth, fluency, and stylistic sophistication.

To address these deficiencies, this paper proposes WRitEer (Writer-Reader iterative tuning with Editor-Driven evolution and refinement), an interactive multi-agent collaborative human-like writing framework. Centered around an LLM, this framework integrates multi-objective optimization with preference fine-tuning techniques. It introduces three synergistic agents: the Reader, responsible for discourse analysis and indicator generation; the Editor, which constructs prompts based on feedback indicators and iteratively refines them through an evolutionary search; and the Writer, which generates text based on these refined prompts and continuously self-optimizes via a DPO mechanism that incorporates preference feedback. Experimental results consistently demonstrate that this ``generate-evaluate-reflect-optimize'' workflow significantly outperforms single LLM models across multiple datasets, yielding advanced rich texts that exhibit superior human-like style, coherence, expressiveness, and controllability. Our code can be found in https://github.com/frontsea320/WRitEer.

WRitEer: A Multi-Objective, Preference-Driven Multi-Agent Framework for Human-Like Advanced Text Generation

Pose graph optimization (PGO) is fundamental to robot perception and navigation systems, serving as the mathematical backbone for solving simultaneous localization and mapping (SLAM). Existing solvers suffer from polynomial growth in computational complexity with graph size, hindering real-time deployment in large-scale scenarios. In this paper, by duplicating variables and introducing equality constraints, we reformulate the problem and propose a Parallelizable Riemannian Alternating Direction Method of Multipliers (PRADMM) to solve it efficiently. Compared with the state-of-the-art methods that usually exhibit polynomial time complexity growth with graph size, PRADMM enables efficient parallel computation across vertices regardless of graph size. Crucially, all subproblems admit closed-form solutions, ensuring PRADMM maintains exceptionally stable performance. Furthermore, by carefully exploiting the structures of the coefficient matrices in the constraints, we establish the global convergence of PRADMM under mild conditions, enabling larger relaxation step sizes within the interval (0,2). Extensive empirical validation on two synthetic datasets and multiple real-world 3D SLAM benchmarks confirms the superior computational performance of PRADMM.

Parallelizable Riemannian Alternating Direction Method of Multipliers for Non-convex Pose Graph Optimization

Articulated object modeling, which represents interconnected rigid bodies with their geometry, part segmentation, articulation tree, and physical properties, is crucial for robotic perception and manipulation. Recently existing methods like SAGCI leverage Interactive Perception (IP) to refine models through robot interaction. However, SAGCI suffers from prior-dependency (requiring initialization), neglects kinematic/dynamic constraints, and generates non-watertight meshes. To overcome these limitations, we propose SIAM, a novel framework for efficient and generalizable Single-Interaction Articulated Modeling. Given an initial point cloud, SIAM first enables minimal robot interaction to trigger object motion. It then precisely segments parts by analyzing point cloud differences pre- and post-interaction. For joint parameter estimation, we introduce an optimization incorporating novel kinematic energy constraints, enhancing physical consistency. Finally, we reconstruct a high-quality, topologically watertight mesh by learning 3D Gaussian Primitives from multi-view RGB-D observations under deformation. Extensive experiments on the PartNet-Mobility benchmark demonstrate state-of-the-art articulation modeling performance. Successful real-world deployment with an xArm robot further validates the framework's practicality and transferability. SIAM achieves accurate, prior-free modeling with significantly reduced interaction cost. Code will be publicly available upon acceptance.

SIAM: Towards Generalizable Articulated Object Modeling via Single Robot-Object Interaction

In community question answering (cQA) platforms like Stack Overflow, related question retrieval is recognized as a fundamental task that allows users to retrieve related questions to answer user queries automatically. Although many traditional approaches have been proposed for investigating this research field, they mostly rely on static approaches and neglect the interaction property. We argue that the conversational way can well distinguish the fine-grained representations of questions and has great potential to improve the performance of question retrieval. In this paper, we propose a related question retrieval model through conversations, called TeCQR, to locate related questions in cQA. Specifically, we build conversations by utilizing tag-enhanced clarifying questions. In addition, we design a noise tolerance model that evaluates the semantic similarity between questions and tags, enabling the model to effectively handle noisy feedback. Moreover, the tag-enhanced two-stage offline training is proposed to fully exploit the mutual relationships among user queries, questions, and tags to learn their fine-grained representations. Based on the learned representations and contextual conversations, TeCQR incorporates conversational feedback by learning to ask tag-enhanced clarifying questions to retrieve related questions more effectively. Experimental results demonstrate that our model significantly outperforms state-of-the-art baselines. \textit{The code and dataset are provided in the Supplementary Materials.}

Beyond Static: Related Questions Retrieval Through Conversations in Community Question Answering

Finding a few solutions for a given problem that are diverse, as opposed to finding a single best solution to solve the problem, has recently become a notable topic in theoretical computer science. Recently, Baste, Fellows, Jaffke, Masařík, Oliveira, Philip, and Rosamond showed that under a standard structural parameterization by treewidth, one can find a set of diverse solutions for many problems with only a very small additional cost [Artificial Intelligence 2022]. In this paper, we investigate a much stronger graph parameter, the cliquewidth, which can additionally describe some dense graph classes. Broadly speaking, it describes graphs that can be recursively constructed by a few operations defined on graphs whose vertices are divided into a bounded number of groups, while each such group behaves uniformly with respect to any operation.

We show that for any vertex problem, if we are given a dynamic program solving that problem on cliquewidth decomposition, we can modify it to produce a few solutions that are as diverse as possible with as little overhead as in the above-mentioned treewidth paper. As a consequence, we prove that a diverse version of any MSO$_1$ expressible problem can be solved in linear FPT time parameterized by cliquewidth, the number of sought solutions, and the number of quantifiers in the formula. That was an important missing piece in the complexity landscape of structural graph parameters and logic. We prove our results, allowing for a more general natural collection of diversity functions compared to only two mostly studied diversity functions previously. That might be of independent interest as a larger pool of different diversity functions can highlight various aspects of different solutions to a problem.

Finding Diverse Solutions Parameterized by Cliquewidth

Multi-character role-playing aims to equip models with the capability to simulate diverse roles. Existing methods either use one shared parameterized module across all roles or assign a separate parameterized module to each role. However, the role-shared module may ignore distinct traits of each role, weakening personality learning, while the role-specific module may overlook shared traits across multiple roles, hindering commonality modeling. In this paper, we propose a novel \textbf{HyCoRA}: \textbf{Hy}per-\textbf{Co}ntrastive \textbf{R}ole-\textbf{A}daptive learning framework, which efficiently improves multi-character role-playing ability by balancing the learning of distinct and shared traits. Specifically, we propose a Hyper-Half Low-Rank Adaptation structure, where one half is a role-specific module generated by a lightweight hyper-network, and the other half is a trainable role-shared module. The role-specific module is devised to represent distinct persona signatures, while the role-shared module serves to capture common traits. Moreover, to better reflect distinct personalities across different roles, we design a hyper-contrastive learning mechanism to help the hyper-network distinguish their unique characteristics. Extensive experimental results on both English and Chinese available benchmarks demonstrate the superiority of our framework. The further GPT-4 evaluations and visual analyses also verify the capability of HyCoRA to capture role characteristics.

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Probabilities Are All You Need: A Probability-Only Approach to Uncertainty Estimation in Large Language Models

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