Multimodal Large Language Models (MLLMs) have recently achieved strong performance across a variety of multimodal tasks. However, they still suffer from various forms of hallucination, which hinder their practical deployment. Prior approaches often struggle to efficiently construct high-quality hallucination-related samples and to process them in a fine-grained manner, resulting in limited effectiveness in hallucination alleviation. To address this issue, we propose a data sampling strategy that selects samples better suited for hallucination-oriented training, thereby enhancing training effectiveness. In addition, we introduce a quantitative method for measuring hallucination severity and assign individualized weights to training samples accordingly. Building on this, we present Hallucination-Differentiated Direct Preference Optimization (HD-DPO), a novel preference optimization framework. During fine-tuning, HD-DPO incorporates these weights into both the formulation of customized loss functions and the modulation of localized visual attention, enabling fine-grained optimization. Experimental results demonstrate that our method outperforms existing fine-tuning strategies across multiple benchmarks and generalizes well to diverse MLLM architectures, effectively reducing hallucination rates and enhancing overall model performance.