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Standardized microplates are used to conduct large-scale biomedical research. The design of microplate layouts plays an essential role in handling so-called plate effects, i.e., systematic variations across the geometry of a microplate. An effective layout allows us to detect and negate plate effects. The randomized placement of controls and compounds produces layouts of limited effectiveness, so specific approaches are needed. A previously developed system, PLAID, proposed a constraint satisfaction model to construct effective plate layouts. However, PLAID does not scale well with microplate dimensions. To improve on PLAID, we propose Constraint Optimization of MicroPlate Designs (COMPD), which allows for greater flexibility and higher quality of the layouts.

AAAI 2026

Constraint Optimization of MicroPlate Designs

poster

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.<br><br>

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

Maximum satisfiability (MaxSAT) is a viable approach to solving NP-hard combinatorial optimization problems through propositional encodings.
Understanding how problem structure and encodings impact the behaviour of different MaxSAT solving algorithms is an important challenge.
In this work, we identify MaxSAT instances in which the constraints entail an ordering of the objective variables as an interesting instance class from the perspectives of problem structure and MaxSAT solving. From the problem structure perspective, we show that a non-negligible percentage of instances in commonly used MaxSAT benchmark sets have ordered objectives and further identify various examples of such problem domains to which MaxSAT solvers have been successfully applied. From the algorithmic perspective, we argue that MaxSAT instances with ordered objectives, provided an ordering, can be solved (at least) as efficiently with a very simplistic algorithmic approach as with modern core-based MaxSAT solving algorithms. We show empirically that state-of-the-art MaxSAT solvers suffer from overheads and are outperformed by the simplistic approach on real-world optimization problems with ordered objectives.

Ordered Objectives in Maximum Satisfiability

During the video encoding process, the original spatial domain signal is first transformed into the frequency domain, followed by quantization and compression. As a result, the quality degradation in compressed videos primarily stems from distortions in the frequency domain information. However, existing video enhancement methods typically directly fuse information from adjacent frames in the spatial domain, making it difficult for models to effectively compensate for frequency domain distortions, which leads to suboptimal detail restoration. To address this issue, we propose a Hierarchical Frequency-Guided Alignment Transformer. Additionally, by analyzing the characteristics of the frequency domain, we find that different frequency bands exhibit both correlations and a certain degree of independence. Based on this, we introduce a Frequency-Aware Transformer module that employs a combination of independent and mixed processing to optimize information exchange across different frequency domains, effectively mitigating cross-interference from irrelevant information. Experimental results demonstrate that, compared to existing methods, our approach achieves state-of-the-art performance in objective metrics (PSNR/SSIM), perceptual quality (LPIPS), and subjective visual effects, while reducing model complexity.

Hierarchical Frequency-Guided Alignment Transformer for Compressed Video Quality Enhancement

Privacy-preserving Transformer inference has gained attention due to the potential leakage of private information. Despite recent progress, existing frameworks still fall short of practical model scales, with gaps up to a hundredfold. A possible way to close this gap is the Mixture of Experts (MoE) architecture, which has emerged as a promising technique to scale up model capacity with minimal overhead. However, given that the current secure two-party (2-PC) protocols allow the server to homomorphically compute the FFN layer with its plaintext model weight, under the MoE setting, this could reveal which expert is activated to the server, exposing token-level privacy about the client's input. While naively evaluating all the experts before selection could protect privacy, it nullifies MoE sparsity and incurs the heavy computational overhead that sparse MoE seeks to avoid. 

To address the privacy and efficiency limitations above, we propose a 2-PC privacy-preserving inference framework, SecMoE. Unifying per-entry circuits in both the MoE layer and piecewise polynomial functions, SecMoE obliviously selects the extracted parameters from circuits and only computes one encrypted entry, which we refer to as Select-Then-Compute. This makes the model for private inference scale to 63$\times$ larger while only having a 15.2$\times$ increase in end-to-end runtime. Extensive experiments show that, under 5 expert settings, SecMoE lowers the end-to-end private inference communication by 1.8$\sim$7.1$\times$ and achieves 1.3$\sim$3.8$\times$ speedup compared to the state-of-the-art (SOTA) protocols.

SecMoE: Communication-Efficient Secure MoE Inference via Select-Then-Compute

While Multimodal Large Language Models (MLLMs) show immense promise for achieving truly human-like interactions, progress is hindered by the lack of fine-grained evaluation frameworks for human-centered scenarios, encompassing both the understanding of complex human intentions and the provision of empathetic, context-aware responses. 
Here we introduce HumanSense, a comprehensive benchmark designed to evaluate the human-centered perception and interaction capabilities of MLLMs, with a particular focus on deep understanding of extended multimodal contexts and the formulation of rational feedback. Our evaluation reveals that leading MLLMs still have considerable room for improvement, particularly for advanced interaction-oriented tasks. Supplementing visual input with audio and text information yields substantial improvements, and Omni-modal models show advantages on these tasks. Furthermore, we argue that appropriate feedback stems from a contextual analysis of the interlocutor's needs and emotions, with reasoning ability serving as the key to unlocking it. Accordingly, we employ a multi-stage, modality-progressive reinforcement learning to enhance the reasoning abilities of an Omni model, achieving substantial gains on evaluation results. Additionally, we observe that successful reasoning processes exhibit highly consistent thought patterns. By designing corresponding prompts, we also enhance the performance of non-reasoning models in a training-free manner.

HumanSense: From Multimodal Perception to Empathetic Context-Aware Responses Through Reasoning MLLMs

Due to the long-range modeling ability and linear complexity property, Mamba has attracted considerable attention in point cloud analysis. Despite some interesting progress, related work still suffers from imperfect point cloud serialization, insufficient high-level geometric perception, and overfitting of the selective state space model (S6) at the core of Mamba. To this end, we resort to an SSM-based point cloud network termed CloudMamba to address the above challenges. Specifically, we propose sequence expanding and sequence merging, where the former serializes points along each axis separately and the latter serves to fuse the corresponding higher-order features causally inferred from different sequences, enabling unordered point sets to adapt more stably to the causal nature of Mamba without parameters. Meanwhile, we design chainedMamba that chains the forward and backward processes in the parallel bidirectional Mamba, capturing high-level geometric information during scanning. In addition, we propose a grouped selective state space model (GS6) via parameter sharing on S6, alleviating the overfitting problem caused by the computational mode in S6. Experiments on various point cloud tasks validate CloudMamba's ability to achieve state-of-the-art results with significantly less complexity.

CloudMamba: Grouped Selective State Spaces for Point Cloud Analysis

Recently, All-in-One image restoration (AIR) techniques have advanced significantly, offering promising solutions for complex real-world degradations. However, most existing approaches heavily rely on degradation-specific representation learning, which can lead to oversmoothing and artifacts in the restored images. To address this limitation, we propose ClearAIR, a novel AIR framework inspired by human visual perception and designed with a hierarchical restoration strategy in a coarse to fine manner. First, leveraging the global priority characteristic of early human visual perception, we employ an image quality assessment model to evaluate the overall image structure and degradation level. Next, to locate the local degradation areas, we introduce an attention-driven regional analysis process. By combining the Segment Anything Model, we achieve regional semantic positioning and use a task recognizer to identify the degradation patterns of the regions, thus realizing a detailed analysis of the local degradation situations. Finally, aiming at the challenge of local detail restoration, we propose an internal clue reuse mechanism. This mechanism deeply mines the internal information of the image in a self-supervised manner and enhances the model’s learning ability for local details. Experimental results demonstrate that ClearAIR achieves superior restoration results across diverse synthetic and real-world datasets.

ClearAIR: A Human-Visual-Perception-Inspired All-in-One Image Restoration

Ensemble attacks integrate the outputs of surrogate models with diverse architectures, which can be combined with various gradient-based attacks to improve adversarial transferability. However, previous work shows unsatisfactory attack performance when transferring across heterogeneous model architectures. The main reason is that the gradient update directions of heterogeneous surrogate models differ widely, making it hard to reduce the gradient variance of ensemble models while making the best of individual model. To tackle this challenge, we design a novel ensemble attack, NAMEA, which for the first time integrates the gradients from the non-attention areas of ensemble models into the iterative gradient optimization process. Our design is inspired by the observation that the attention areas of heterogeneous models vary sharply, thus the non-attention areas of ViTs are likely to be the focus of CNNs and vice versa. Therefore, we merge the gradients respectively from the attention and non-attention areas of ensemble models so as to fuse the transfer information of CNNs and ViTs. Specifically, we pioneer a new way of decoupling the gradients of non-attention areas from those of attention areas, while merging gradients by meta-learning. Empirical evaluations on ImageNet dataset indicate that NAMEA outperforms AdaEA and SMER, the state-of-the-art ensemble attacks by an average of 15.0% and 9.6%, respectively. This work is the first attempt to explore the power of ensemble non-attention in boosting cross-architecture transferability, providing new insights into launching ensemble attacks.

Boosting Adversarial Transferability via Ensemble Non-Attention

Remote sensing images are becoming increasingly widespread in military, earth resource exploration, and environmental monitoring. Because of the limitation of a single sensor, we can obtain high spatial resolution grayscale panchromatic (PAN) images and low spatial resolution color multispectral (MS) images. Therefore, an important issue is to obtain a color image with high spatial resolution when there is only a PAN image at the input. The existing methods improve spatial resolution using super-resolution (SR) technology and spectral recovery using colorization technology. However, the SR technique cannot improve the spectral resolution, and the colorization technique cannot improve the spatial resolution. Moreover, the pansharpening method needs two registered inputs and can not achieve SR. As a result, an integrated approach is expected. To solve the above problems, we designed a novel multi-function model (MFmamba) to realize the tasks of SR, spectral recovery, joint SR and spectral recovery through three different inputs. Firstly, our MFmamba utilizes UNet++ as the backbone, and a Mamba Upsample Block (MUB) is combined with UNet++. Secondly, a Dual Pool Attention (DPA) is designed to replace the skip connection in UNet++. Finally, a Multi-scale Hybrid Cross Block (MHCB) is proposed for initial feature extraction. Many experiments show that MFmamba is competitive in evaluation metrics and visual results and performs well in the three tasks when only the input PAN image is used.

MFmamba: A Multi-function Network for Panchromatic Image Resolution Restoration Based on State-Space Model

Among the diverse services provided by Location-Based Social Networks (LBSNs), Next Point-of-Interest (POI) recommendation plays a crucial role in inferring user preferences from historical check-in trajectories. However, existing sequential and graph-based methods frequently neglect significant mobility variations across distinct contextual scenarios (e.g., tourists versus locals). This oversight results in suboptimal performance due to two fundamental limitations: the inability to capture scenario-specific features and the failure to resolve inherent inter-scenario conflicts. To overcome these limitations, we propose the \underline{\bf{M}}ultifaceted \underline{\bf{S}}cenario-\underline{\bf{A}}ware \underline{\bf{H}}yper\underline{\bf{g}}raph Learning method (MSAHG), a framework that adopts a scenario-splitting paradigm for next POI recommendation.
Our main contributions are:
(1) Construction of scenario-specific, multi-view disentangled sub-hypergraphs to capture distinct mobility patterns;
(2) A parameter-splitting mechanism to adaptively resolve conflicting optimization directions across scenarios while preserving generalization capability.
Extensive experiments on three real-world datasets demonstrate that MSAHG consistently outperforms five state-of-the-art methods across diverse scenarios, confirming its effectiveness in multi-scenario POI recommendation. Our code is publicly available at {https://anonymous.4open.science/r/AAAI26-MSAHG}.

Multifaceted Scenario-Aware Hypergraph Learning for Next POI Recommendation

Traffic forecasting is essential for intelligent transportation systems. Accurate forecasting relies on continuous observations collected by traffic sensors. However, due to high deployment and maintenance costs, not all regions are equipped with such sensors. This paper aims to forecast for regions without traffic sensors, where the lack of historical traffic observations challenges the generalisability of existing models. We propose a model named **GenCast**, the core idea of which is to exploit external knowledge to compensate for the missing observations and to enhance generalisation. We integrate physics-informed neural networks into GenCast, enabling physical principles to regularise the learning process. We introduce an external signal learning module to explore correlations between traffic states and external signals such as weather conditions, further improving model generalisability. Additionally, we design a spatial grouping module to filter localised features that hinder model generalisability. Extensive experiments show that GenCast consistently reduces forecasting errors on multiple real-world datasets.

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