Active domain adaptation (ADA) aims to select a small set of target samples for annotation and use them for training to maximally boost the adaptation performance. However, most existing ADA methods only rely on the original output of the model, without considering the relationship between the source and target domain features, which may lead to selecting uninformative samples. In this paper, we propose an effective ADA framework: Prototype-Driven Active Domain Adaptation with density consideration (PDADA). It selects the most valuable target samples in the presence of domain shift through two criteria: Density-Conscious Domainness (DCD) and Prototype-Driven Informativeness (PDI). Furthermore, considering the class imbalance and cluster looseness issues in sample selection and domain adaptation, we develop a Class Balanced Expansion (CBE) algorithm and the Adversarial Active Domain Adaptation via Protecting Structured Information (AADA-PSI). Extensive experiments demonstrate that under the cooperation of the above components, PDADA outperforms previous methods on several challenging benchmarks and can be generalized to multi-source active domain adaptation setting.