Singapore

Single-cell RNA sequencing (scRNA-seq) is essential for decoding tumor heterogeneity. However, pan-cancer research still faces two key challenges: learning discriminative and efficient single-cell representations, and establishing a comprehensive evaluation benchmark. In this paper, we introduce \algoname, a lightweight hybrid neural network that combines the strengths of Transformers and state-space models to achieve a balance between performance and efficiency. \algoname consists of a front-end local-context encoder with shared self-attention layers to capture complex, order-independent gene interactions; and a back-end global sequential feature decoder that efficiently integrates global context using a linear-time state-space model. This modular design preserves the expressive power of Transformers while leveraging the scalability of Mamba to enable transcriptome modeling, effectively capturing both local and global regulatory signals. To enable robust evaluation, we also construct a large-scale pan-cancer single-cell benchmark, \algoname Bench, containing over 3.5 million high-quality cells across 33 cancer subtypes, curated through a rigorous preprocessing pipeline. Experimental results show that \algoname outperforms state-of-the-art models on our pan-cancer benchmark (+4.0\%) and across multiple public tasks, including cell type annotation (+7.4\%), batch integration (+4.0\%) and multi-omics integration (+3.1\%).

AAAI 2026

PanFoMa: A Lightweight Foundation Model and Benchmark for Pan-Cancer

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.<br><br>

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

While Multimodal Large Language Models (MLLMs) demonstrate remarkable capabilities across diverse domains, their application to specialized anomaly detection (AD) remains constrained by domain adaptation challenges. Existing Group Relative Policy Optimization (GRPO) based approaches suffer from two critical limitations: inadequate training data utilization when models produce uniform responses, and insufficient supervision over reasoning processes that encourage immediate binary decisions without deliberative analysis.
We propose a comprehensive framework addressing these limitations through two synergistic innovations. First, we introduce a multi-stage deliberative reasoning process that guides models from region identification to focused examination, generating diverse response patterns essential for GRPO optimization while enabling structured supervision over analytical workflows. Second, we develop a fine-grained reward mechanism incorporating classification accuracy and localization supervision, transforming binary feedback into continuous signals that distinguish genuine analytical insight from spurious correctness.
Comprehensive evaluation across multiple industrial datasets demonstrates substantial performance improvements in adapting general vision-language models to specialized anomaly detection. Our method achieves superior accuracy with efficient adaptation of existing annotations, effectively bridging the gap between general-purpose MLLM capabilities and the fine-grained visual discrimination required for detecting subtle manufacturing defects and structural irregularities.

AD-FM: Multimodal LLMs for Anomaly Detection via Multi-Stage Reasoning and Fine-Grained Reward Optimization

Molecular evolution is the process of simulating the natural evolution of molecules in chemical space to explore potential molecular structures and properties. The relationships between similar molecules are often described through transformations such as adding, deleting, and modifying atoms and chemical bonds, reflecting specific evolutionary paths. Existing molecular representation methods mainly focus on mining data, such as atomic-level structures and chemical bonds directly from the molecules, often overlooking their evolutionary history. Consequently, we aim to explore the possibility of enhancing molecular representations by simulating the evolutionary process. We extract and analyze the changes in the evolutionary pathway and explore combining it with existing molecular representations. Therefore, this paper proposes the molecular evolutionary network (MEvoN) for molecular representations. First, we construct the MEvoN using molecules with a small number of atoms and generate evolutionary paths utilizing similarity calculations. Then, by modeling the atomic-level changes, MEvoN reveals their impact on molecular properties. Experimental results show that the MEvoN-based molecular property prediction method significantly improves the performance of traditional end-to-end algorithms by approximately 33% on both the QM7 and QM9 datasets. The code and implementation details are provided in the appendix.

Can Molecular Evolution Mechanism Enhance Molecular Representation?

In multimodal sentiment analysis, modality missingness and quality degradation are common. Existing methods often rely on batch-level modality generation, generation but neglect sample-level missingness, hence their flexibility is limited severely in real-world scenarios. To address this, Sample-specific Modality Diagnosis and Cross-modal Enhancement for Incomplete Multimodal Representations (SMCIR) is proposed. Specifically, The Dynamic Multi-feature Fusion Detector (DMFD) is presented, which detects missingness and severity at the sample-level using indicators such as information entropy, modality similarity, and mutual information. Unlike batch-based methods, the DMFD provides fine-grained detection and adaptive responses, improving sensitivity to modality disturbances. Meanwhile, the Context-aware Modality Completion Generator (CMCG) is developed to restore missing modalities through context-guided reconstruction using multiscale feature fusion and cross-modal attention. In this way, the proposed CMCG method can avoid redundancy and inconsistency, enhancing the consistency and discriminativity of the fused representation. In CMCG, the text modality serves as a stable guide to improve context consistency. Experiments on the CMU-MOSI and CMU-MOSEI datasets show that SMCIR outperforms existing full-modal and non-recovery-based methods, well validating its efficacy and superiority in multimodal learning.

Sample-specific Modality Diagnosis and Cross-modal Enhancement for Incomplete Multimodal Representations

Multi-relational graph clustering aims to uncover complex node interactions by leveraging multiple relational views, yet existing methods often suffer from two key limitations: they assume equal importance across views and decouple representation learning from clustering, both of which hinder overall performance. To address these issues, we propose OMC-DVM, a novel end-to-end Online Multi-Relational Graph Clustering With Dominant View Mining framework. 
OMC-DVM introduces two core innovations: (1) A unsupervised dominant view mining module that dynamically identifies the dominant view using Maximum Mean Discrepancy (MMD) and adaptively aligns other views to it, mitigating view imbalance. 
(2) An online ,multi-relational clustering process that unifies representation learning and clustering into a single stage.
By performing clustering-level contrastive learning , OMC-DVM directly generates cluster assignments in an end-to-end manner.

Online Multi-Relational Clustering with Dominant View Mining

Goal-conditioned Hierarchical Reinforcement Learning (GCHRL) has demonstrated effectiveness in addressing complicated decision-making tasks by providing ''temporal extraction'', which decomposes tasks into smaller and more manageable ''subgoals''. This enables agents to plan over a longer time scale. However, achieving optimal exploration and exploitation still remains a challenge, especially for long-horizon or sparse-reward scenarios. In this paper, we introduce Active exploraion and hierarchical Self-Imitation (ASI), an effective scheme to enhance exploration and exploitation based on subgoal representation learning. The key point of ASI is to utilize temporal adjacency information in the representation space. We construct and dynamically update an adjacency graph that captures the relationships between subgoals. Based on the adjacency information provided by the graph, we design two mechanisms: (1) active ``frontier-reaching'' exploration that faster expands the explored area by targeting boundary regions, and (2) hierarchical self-imitation learning that leverages historical experience to facilitate both frontier reaching and policy training. Experimental results show that our method accelerates exploration and outperforms existing baselines in challenging long-horizon continuous control tasks.

Enhancing Exploration and Exploitation in Hierarchical Reinforcement Learning with Subgoal Graph Learning

Multi-objective combinatorial optimization problems (MOCOP) frequently arise in practical applications that require the simultaneous optimization of conflicting objectives. Although traditional evolutionary algorithms can be effective, they typically depend on domain knowledge and repeated parameter tuning, limiting flexibility when applied to unseen MOCOP instances. Recently, integration of Large Language Models (LLMs) into evolutionary computation has opened new avenues for automatic heuristic generation, using their advanced language understanding and code synthesis capabilities. Nevertheless, most existing approaches predominantly focus on single-objective tasks, often neglecting key considerations such as runtime efficiency and heuristic diversity in multi-objective settings. To bridge this gap, we introduce Multi-heuristics for MOCOP via Pareto-Grid-guided Evolution of LLMs (MPaGE), a novel enhancement of the Simple Evolutionary Multiobjective Optimization (SEMO) framework that leverages LLMs and Pareto Front Grid (PFG) technique. By partitioning the objective space into grids and retaining top-performing candidates to guide heuristic generation, MPaGE utilizes LLMs to prioritize heuristics with semantically distinct logical structures during variation, thus promoting diversity and mitigating redundancy within the population. Through extensive evaluations, MPaGE demonstrates superior performance over existing LLM-based frameworks, and achieves competitive results to traditional Multi-objective evolutionary algorithms (MOEAs), with significantly faster runtime.

Pareto-Grid-Guided Large Language Models for Fast and High-Quality Heuristics Design in Multi-Objective Combinatorial Optimization

Joint multilingual instruction tuning is a widely adopted approach to improve the multilingual instruction-following ability and downstream performance of large language models (LLMs), but the resulting multilingual capability remains highly sensitive to the composition and selection of the training data.
Existing selection methods, often based on features like text quality, diversity, or task relevance, typically overlook the intrinsic linguistic structure of multilingual data.
In this paper, we propose LangGPS, a lightweight two-stage pre-selection framework guided by language separability—a signal that quantifies how well samples in different languages can be distinguished in the model’s representation space. LangGPS first filters training data based on separability scores and then refines the subset using existing selection methods.
Extensive experiments across six benchmarks and 22 languages demonstrate that applying LangGPS on top of existing selection methods improves their effectiveness and generalizability in multilingual training, especially for understanding tasks and low-resource languages.
Further analysis reveals that highly separable samples facilitate the formation of clearer language boundaries and support faster adaptation, while low-separability samples tend to function as bridges for cross-lingual alignment.
Besides, we also find that language separability can serves as an effective signal for multilingual curriculum learning, where interleaving samples with diverse separability levels yields stable and generalizable gains.
Together, we hope our work offers a new perspective on data utility in multilingual contexts and support the development of more linguistically informed LLMs.

LangGPS: Language Separability Guided Data Pre-Selection for Joint Multilingual Instruction Tuning

In this paper, we investigate code-integrated reasoning (CIR), where models generate code when necessary and integrate feedback by executing it through a code interpreter. To acquire this capability, models must learn when and how to use external code tools effectively, which is supported by tool-augmented reinforcement learning (RL). Despite its benefits, tool-augmented RL can still suffer from potential instability in the learning dynamics. In light of this challenge, we present a systematic approach ETIR (Effective TIR) to improving the training effectiveness and stability of tool-augmented RL for code-integrated reasoning. Specifically, we develop enhanced training strategies that balance exploration and stability, progressively building tool-use capabilities while improving reasoning performance. Through extensive experiments on five mainstream mathematical reasoning benchmarks, our model demonstrates significant performance improvements over multiple competitive baselines. Furthermore, we conduct an in-depth analysis of the mechanism of code-integrated reasoning, revealing several key insights, such as the extension of model’s capability boundaries and the simultaneous improvement of reasoning efficiency through code integration. These findings underscore the potential of code-integrated reasoning as a scalable paradigm for advancing robust and efficient language model reasoning.

Towards Effective Code-Integrated Reasoning

Efficiently fine-tuning pre-trained models for downstream tasks is a key challenge in the era of foundation models. Parameter-efficient fine-tuning (PEFT) presents a promising solution, achieving performance comparable to full fine-tuning by updating only a small number of adaptation weights per layer. Traditional PEFT methods typically rely on a single expert, where the adaptation weight is a low-rank matrix. However, for complex tasks, the data's inherent diversity poses a significant challenge for such models, as a single adaptation weight cannot adequately capture the features of all samples. To address this limitation, we explore how to integrate multiple **small** adaptation experts into a compact structure to defeat a **large** adapter. Specifically, we propose Tucker Adaptation (TuckA), a method with four key properties: (i) We use Tucker decomposition to create a compact 3D tensor where each slice naturally serves as an expert. The low-rank nature of this decomposition ensures that the number of parameters scales efficiently as more experts are added. (ii) We introduce a hierarchical strategy that organizes these experts into groups at different granularities, allowing the model to capture both local and global data patterns. (iii) We develop an efficient batch-level routing mechanism, which reduces the router's parameter size by a factor of $L$ compared to routing at every adapted layer (where $L$ is the number of adapted layers) (iv) We propose data-aware initialization to achieve loss-free expert load balancing based on theoretical analysis. Extensive experiments on benchmarks in natural language understanding, image classification, and mathematical reasoning speak to the efficacy of TuckA, offering a new and effective solution to the PEFT problem.

TuckA: Hierarchical Compact Tensor Experts for Efficient Fine-Tuning

Clinical reinforcement learning (RL) holds promise for treatment recommendation but remains hindered by black-box decision processes, limited safety guarantees, and lack of individualized reasoning. We introduce Delphi Engine, the first fully trainable neuro-symbolic causal RL framework for dynamic treatment planning, designed to answer three core clinical questions in real time: Why this action? Why is it safe? Why for this patient?
Specifically, Delphi integrates: (1) causality-aware state modeling using discretized physiological variables and subtype-specific causal graphs; (2) adaptive symbolic rule constraints, combining clinical guidelines and behavior-derived rules into soft differentiable logic; and (3) interpretable decision fusion, where actions are selected based on joint neural-symbolic Q-values and explained via structured LLM-based justifications.
We evaluate Delphi on the MIMIC-III sepsis cohort using both standard off-policy evaluations (WIS↑1.47, DR↑1.29, RMSE↓0.207) and the first blinded physician evaluation of an explainable RL system in healthcare. Delphi consistently outperforms historical physicians' treatments in safety (+10.4\%), understandability (+8.9\%), and adoption rate (+5.75\%) across six clinical axes. These results highlight Delphi’s potential as a safe, interpretable, and patient-specific AI assistant for critical care.

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