Reconstructing 3D scenes from multi-view image sequences remains a significant challenge in practical applications. While recent advances in 3D Gaussian Splatting have enabled high-quality rendering, existing methods rely heavily on pixel-level $\mathcal{L}_1$ loss, which misaligns with human perception, leading to a lack of high-frequency details and the emergence of artifacts. Additionally, the position gradient-based densification strategy often results in under-densified Gaussian primitives, thereby desgrading rendering quality. To address these challenges, we propose Pano-GS, a perception-aware Gaussian optimization framework. Specifically, we introduce a gradient consistency-constrained loss to capture high-frequency details, mitigating the inherent shortcomings of traditional $\mathcal{L}_1$ loss and enhancing reconstruction fidelity. In addition, we use a multi-criteria densification strategy to reduce the sole reliance on average position gradients. Extensive experiments demonstrate that Pano-GS achieves state-of-the-art performance, confirming its effectiveness and robust generalization across diverse real-world scenes.