Dataset distillation has achieved remarkable progress as an effective approach for data compression. However, real-world data often comes from diverse domains, leading to potential mismatches between the domains of synthesized images and those of the evaluation set. Existing methods primarily assume domain alignment between them, which limits their generalization ability in the above cross-domain scenarios. In this paper, we aim to ensure that images synthesized from known domains maintain robust performance on unseen domains and propose a novel framework called Channel-masked Asymmetric Distribution Matching (CADM). During asymmetric distribution matching, domain-sensitive channels of real data are selectively masked at different layers to extract domain-invariant features that guide synthetic data optimization. To further improve synthetic data representation, we introduce a class-focused domain-agnostic regularization to capture class-relevant knowledge while ignoring domain-specific information. Experiments show that our method produces domain-robust synthetic data and substantially improves generalization performance on unseen domains.