Singapore

Recent advances in large language models (LLMs) have enabled their application to a range of healthcare tasks. However, aligning LLMs with the nuanced demands of medical ethics, especially under complex real-world scenarios, remains underexplored. In this work, we present MedES, a dynamic, scenario-centric benchmark specifically constructed from 260 authoritative Chinese medical, ethical, and legal sources to reflect the challenges in clinical decision-making. To facilitate model alignment, we introduce a guardian-in-the-loop framework that leverages a dedicated automated evaluator—trained on expert-labeled data and achieving over 97% accuracy within our domain—to generate targeted prompts and provide structured ethical feedback. Using this pipeline, we align a 7B-parameter LLM through supervised fine-tuning and domain-specific preference optimization. Experimental results, conducted entirely within the Chinese medical ethics context, demonstrate that our aligned model outperforms notably larger baselines on core ethical tasks, with observed improvements in both quality and composite evaluation metrics. Our work offers a practical and adaptable framework for aligning LLMs with medical ethics in the Chinese healthcare domain, and suggests that similar alignment pipelines may be instantiated in other legal and cultural environments through modular replacement of the underlying normative corpus.

AAAI 2026

A Human-Centric Pipeline for Aligning Large Language Models with Chinese Medical Ethics

app: natural sciences (healthcare)

nlp: prompt engineering / (large) language models

peai: morality & value-based ai

robustness & trustworthiness

peai: safety

poster

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.<br><br>

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

Artificial intelligence (AI) is playing an increasingly important role in supporting decision-making, particularly in educational contexts, where it serves as a critical tool to assist teacher judgment and optimize instructional decisions. However, limited research has examined how different AI-assisted decision-making paradigms influence the quality of human–AI collaboration, as well as the underlying psychological mechanisms and causal pathways. Therefore, this study investigated 59 pre-service teachers to examine how AI-assisted decision-making paradigms and human-AI consistency influenced their psychological states and task performance. Specifically, this study employed a two-factor mixed experimental design, with the AI-assisted decision-making paradigms as the between-subjects factor and human-AI consistency as the within-subjects factor. Data were analyzed using a combination of generalized linear mixed models (GLMM) and structural equation modeling (SEM). The results reveal that AI-assisted decision-making paradigms do not have a significant direct effect on task performance. Their effects are exerted indirectly through a sequential mediation mechanism involving users’ confidence and their trust in AI. Consistency between human and AI decisions not only significantly enhances users’ trust in AI and their task performance, but the proportion of consistent decisions also significantly moderates the effect of AI-assisted decision-making paradigms on users’ confidence levels. Notably, our findings indicate that users maintain a moderately high level of trust in AI even when their decisions diverge from those of AI. In summary, this study highlights the mediating mechanism by which AI-assisted decision-making paradigms influence task performance through psychological states and identifies the moderating role of human–AI consistency in this pathway. These findings advance the theoretical understanding of human–AI interaction models in educational contexts and offer mechanistic insights to guide the optimization of instructional AI systems.

Shaping Human–AI Collaboration in Education: Effects of AI-Assisted Decision-Making Paradigms and Human–AI Decision Consistency on Pre-Service Teachers’ Psychological States and Performance

Low-resource machine translation remains a significant challenge for large language models (LLMs), which often lack exposure to these languages during pretraining and have limited parallel data for fine-tuning. We propose a novel approach that enhances translation for low-resource languages by integrating an external dictionary tool and training models end-to-end using reinforcement learning, in addition to supervised fine-tuning. Focusing on the Spanish–Wayuunaiki language pair, we frame translation as a tool-augmented decision-making problem in which the model can selectively consult a bilingual dictionary during generation. Our method combines supervised instruction tuning with Group Relative Policy Optimization (GRPO), enabling the model to learn both when and how to use the tool effectively. BLEU similarity scores are used as rewards to guide this learning process. Preliminary results show that our tool-augmented models achieve up to +3.37 BLEU improvement over previous work, and a 18\% relative gain compared to a supervised baseline without dictionary access, on the Spanish–Wayuunaiki test set from the AmericasNLP 2025 Shared Task. We also conduct ablation studies to assess the effects of model architecture and training strategy, comparing Qwen2.5-0.5B-Instruct with other models such as LLaMA and a prior NLLB-based system. These findings highlight the promise of combining LLMs with external tools and the role of reinforcement learning in improving translation quality in low-resource language settings.

Improving Low-Resource Translation with Dictionary-Guided Fine-Tuning and RL: A Spanish-to-Wayuunaiki Study

Child malnutrition remains a global crisis, yet existing screening methods are laborious and poorly scalable, hindering early intervention. In this work, we present NutriScreener, a retrieval-augmented, multi-pose graph attention network that combines CLIP-based visual embeddings, class-boosted knowledge retrieval, and context awareness to enable robust malnutrition detection and anthropometric prediction from children's images, simultaneously addressing generalizability and class-imbalance. In a clinical study, doctors rated it 4.3/5 for accuracy and 4.6/5 for efficiency, confirming its deployment readiness in low-resource settings. Trained and tested on 2,141 children from AnthroVision and additionally evaluated on diverse cross-continent populations, including ARAN and an in-house Adult dataset. It achieves 0.79 recall, 0.82 AUC, and significantly lower anthropometric RMSEs, demonstrating reliable measurement in unconstrained, pediatric settings. Cross-dataset results show up to 25\% recall gain and up to 3.5 cm RMSE reduction using demographically matched knowledge bases. NutriScreener offers a scalable and accurate solution for early malnutrition detection in low-resource environments.

NutriScreener: Retrieval Augmented Multi-Pose Graph Attention Network for Malnourishment Screening

While state-of-the-art large language models (LLMs) have shown impressive performance on many tasks, systematically evaluating undesirable behaviors of these models remains critical. In this work, we investigate how the quality of LLM responses changes in terms of information accuracy, truthfulness, and refusals depending on three user traits: English proficiency, education level, and country of origin. We present extensive experimentation on three state-of-the-art LLMs and two different datasets targeting truthfulness and factuality. Our findings suggest that undesirable behaviors in state-of-the-art LLMs occur disproportionately more for users with lower English proficiency, of lower education status, and originating from outside the US, rendering these models unreliable sources of information towards their most vulnerable users.

LLM Targeted Underperformance Disproportionately Impacts Vulnerable Users

Automated interpretation of medical images demands robust modeling of complex visual-semantic relationships while addressing annotation scarcity, label imbalance, and clinical plausibility constraints. We introduce MIRNet (Medical Image Reasoner Network), a novel framework that integrates self-supervised pre-training with constrained graph-based reasoning. Tongue image diagnosis is a particularly challenging domain that requires fine-grained visual and semantic understanding. Our approach leverages self-supervised masked autoencoder (MAE) to learn transferable visual representations from unlabeled data; employs graph attention networks (GAT) to model label correlations through expert-defined structured graphs; enforces clinical priors via constraint-aware optimization using KL divergence and regularization losses; and mitigates imbalance using asymmetric loss (ASL) and boosting ensembles. To address annotation scarcity, we also introduce TongueAtlas-4K, a comprehensive expert-curated benchmark comprising 4,000 images annotated with 22 diagnostic labels–representing the largest public dataset in tongue analysis. Validation shows our method achieves state-of-the-art performance. While optimized for tongue diagnosis, the framework readily generalizes to broader diagnostic medical imaging tasks. Code is available at https://github.com/zijie8247/MIRNet.

MIRNet: Integrating Constrained Graph-Based Reasoning with Pre-training for Diagnostic Medical Imaging

Understanding the communicative behaviors of non- and minimally-speaking individuals with autism spectrum disorder (ASD) and other complex neurodevelopmental disorders (NDDs) remains a critical challenge for both clinical support and machine learning research. However, developing automated systems for this task is hindered by data scarcity, privacy concerns, heterogeneous and idiosyncratic actions, and the significant domain shift from neurotypical to neurodiverse populations. To address these challenges, we first present a novel, large-scale, privacy-preserving 3D skeleton action recognition dataset with 2,721 samples capturing in-home interactions of nonverbal individuals with ASD and complex NDDs. Second, we propose AXON, a novel cross-modal knowledge distillation method that transfers the rich semantic understanding of a pre-trained CLIP model to a graph-based skeleton model, outperforming other cross-modal knowledge distillation baselines in classifying subtle communicative acts. We further introduce a gradient-based interpretability analysis method to characterize how individuals with ASD and complex NDDs perform communicative actions. Our analysis reveals both population- and individual-level communicative styles, showcasing individual biases and idiosyncratic movements. Our foundational study helps the development of more adaptive and personalized augmentative technologies, aiming to foster greater communicative autonomy and understanding for this underserved population.

AXON: Action Characterization Through Cross-Modal Knowledge Distillation for Neurodiverse Individuals

Invasive mechanical ventilation (MV) is a life-sustaining therapy commonly used in the intensive care unit (ICU) for patients with severe and acute conditions. These patients frequently rely on MV for breathing. Given the high risk of death in such cases, optimal MV settings can reduce mortality, minimize ventilator-induced lung injury, shorten ICU stays, and ease the strain on healthcare resources. However, optimizing MV settings remains a complex and error-prone process due to patient-specific variability. While Offline Reinforcement Learning (RL) shows promise for optimizing MV settings, current methods struggle with the hybrid (continuous and discrete) nature of MV settings. Discretizing continuous settings leads to exponential growth in the action space, which limits the number of optimizable settings. Converting the predictions back to continuous can cause a distribution shift, compromising safety and performance.
To address this challenge, we constrain the action space and employ factored action critics. This approach allows us to scale to six optimizable settings compared to 2-3 in previous studies. 
We adapt SOTA offline RL algorithms to operate directly on hybrid action spaces, avoiding the pitfalls of discretization. 
We also introduce a clinically grounded reward function based on ventilator-free days and physiological targets. Using multi-objective optimization for reward selection, we show that this leads to a more equitable consideration of all clinically relevant objectives.
Notably, we develop a system in close collaboration with healthcare professionals that is aligned with real-world clinical objectives and designed with future deployment in mind.

Advancing Safe Mechanical Ventilation Using Offline RL with Hybrid Actions and Clinically Aligned Rewards

Online peer-support communities are vital for mental health, but their therapeutic benefit hinges on receiving a timely and helpful first reply. Posts that languish unanswered can exacerbate feelings of distress and abandonment. This paper develops and validates an integrated framework to predict, explain, and reduce this ``reply gap" on Reddit. First, using survival analysis on over 91,000 posts (2018–2025), we show that a deep learning model (DySurv) can accurately predict reply times (C-Index = 0.742), with a post's lexico-semantic content being a far stronger predictor than author history. Second, moving from correlation to causation, we use a causal inference framework on 48,612 posts to estimate the effect of different support types. We find that initial replies providing emotional support are most effective, increasing the odds of a positive user response by 49% (OR=1.49), an effect most pronounced for high-risk users. Third, we operationalize these insights in RiskMatch, a recommender system that routes at-risk posts to historically effective helpers. Rigorous counterfactual evaluation using inverse propensity scoring (IPS)—a method that corrects for biases in historical data—demonstrates that our system reduces the median wait time by 26 minutes for the highest-risk quintile. This work provides a validated, data-driven methodology to build more responsive and effective peer-support ecosystems, offering a concrete pathway to ensure fewer calls for help go unanswered.

Mind the Gap: Predicting, Explaining and Reducing Time-to-First-Comment (Reply Gap) in Online Mental-Health Communities

Few-shot multimodal industrial anomaly detection is a critical yet underexplored task, offering the ability to quickly adapt to complex industrial scenarios. In few-shot settings, insufficient training samples often fail to cover the diverse patterns present in test samples. This challenge can be mitigated by extracting structural commonality from a small number of training samples. In this paper, we propose a novel few-shot unsupervised multimodal industrial anomaly detection method based on structural commonality, CIF (Commonality In Few). To extract intra-class structural information, we employ hypergraphs, which are capable of modeling higher-order correlations, to capture the structural commonality within training samples, and use a memory bank to store this intra-class structural prior. Firstly, we design a semantic-aware hypergraph construction module tailored for single-semantic industrial images, from which we extract common structures to guide the construction of the memory bank. Secondly, we use a training-free hypergraph message passing module to update the visual features of test samples, reducing the distribution gap between test features and features in the memory bank. We further propose a hyperedge-guided memory search module, which utilizes structural information to assist the memory search process and reduce the false positive rate. Experimental results on the MVTec 3D-AD dataset and the Eyecandies dataset show that our method outperforms the state-of-the-art (SOTA) methods in few-shot settings.

Commonality in Few: Few-Shot Multimodal Anomaly Detection via Hypergraph-Enhanced Memory

Unsupervised cross-modal hashing has gained significant attention for efficient retrieval between heterogeneous modalities through encoding data into the unified binary representations, offering low storage cost and fast response. However, the constraints of existing methods persist in bridging the cross-modal semantic gap and capturing fine-grained global semantic structures without explicit labels. In this paper, we propose an innovative unsupervised Stationary distribution and soft Clustering Transformer Hashing approach for cross-modal retrieval, denoted as SCTH. Initially, a Transformer-based modality fusion encoder is employed to extract abundant cross-modal semantic representations, further integrated with contrastive hashing to minimize the semantic gap. To enhance the inter-modal alignment, a pseudo-classifier clustering module with entropy-regularized contrastive loss is presented, ensuring balanced and diverse cluster assignments in unsupervised settings. Additionally, a Markovian stationary distribution strategy stabilizes the feature representations through mitigating the interference of noise and outliers. Comprehensive experiments on MIRFlickr, NUS-WIDE, and IAPR-TC12 datasets validate that SCTH outperforms state-of-the-art hashing methods in cross-modal retrieval tasks, demonstrating superior generalization performance.

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Shaping Human–AI Collaboration in Education: Effects of AI-Assisted Decision-Making Paradigms and Human–AI Decision Consistency on Pre-Service Teachers’ Psychological States and Performance

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