EMNLP 2025

November 06, 2025

Suzhou, China

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In pharmacovigilance, effective automation of medical data structuring, especially linking entities to standardized terminologies such as MedDRA, is critical. This challenge is rarely addressed for German data. With MedLinkDE we address German MedDRA entity linking for adverse drug reactions in a two-step approach: (1) retrieval of medical terms with fine-tuned embedding models, followed (2) by guided chain-of-thought re-ranking using LLMs. To this end, we introduce RENOde, a German real-world MedDRA dataset consisting of reportings from patients and healthcare professionals. To overcome the challenges posed by the linguistic diversity of these reports, we generate synthetic data mapping the two reporting styles of patients and healthcare professionals. Our embedding models, fine-tuned on these synthetic, quasi-personalized datasets, show competitive performance with real datasets in terms of accuracy at high top- recall, providing a robust basis for re-ranking. Our subsequent guided Chain of Thought (CoT) re-ranking, informed by MedDRA coding guidelines, improves entity linking accuracy by approximately 15% (Acc@1) compared to embedding-only strategies. In this way, our approach demonstrates the feasibility of entity linking in medical reports under the constraints of data scarcity by relying on synthetic data reflecting different informant roles of reporting persons.

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EMNLP 2025

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mingfan@mail.xjtu.edu.cn Fan and 8 other authors

06 November 2025

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