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Sixteen of the world’s fifty known species of box jellyfish are associated with Irukandji syndrome, which causes a multitude of delayed reactionary and potentially life-threatening symptoms. The primary species that release the potent fast acting Irukandji-causing venoms are the Carukia barnesi jellyfish, of the Carybdea genus. These box jellyfish are native to Australian waters where most of the Irukandji syndrome cases occur. However, cases of Irukandji-like syndrome have been reported worldwide after envenomations by Carybdea jellyfish. Herein we report a probable new case of Irukandji-like syndrome in the US Florida Keys, a region where Carybdea jellyfish have not been recorded. While it is unclear which exact jellyfish is the causal organism, the clustering incidents in the Florida Keys suggest a possible new box jellyfish or a member of the Carybdied genus are causing Irukandji-like syndrome in the area.
