The analysis of pesticides and PFAS in food is crucial for ensuring consumer safety and regulatory compliance. High-resolution mass spectrometry (HRMS) in full scan mode offers accurate and comprehensive detection.  Many labs have adopted the technique for qualitative screening, confirming results from standard SRM triple quadrupole MS analysis, and for non-targeted workflows.  However, its use for routine targeted quantitative analysis has often been neglected due to a) requirement of highly skilled operators, b) cost of HRMS systems c) complex method development involving choice of acquisition mode combinations such as data-dependent and other MS2 precursor isolation techniques and d) overall sensitivity.    We describe an alternative approach in which the HRMS is coupled to a dual channel liquid chromatography (LC) system and run with dedicated conditions using a single full scan HRMS acquisition method with in-source fragmentation that requires little, or no method development by the user.  It facilitates robust and reliable residue analysis compliant with regulatory guidelines.  To satisfy requirements, 2 ions were monitored per compound. This was obtained through in-source fragmentation at 3 increasing energy values. This approach allows monitoring specific ions and fragments at high resolution / low ppm mass accuracy, along with ion ratio calculations for each analyte. Specifically designed view settings within Chromeleon CDS facilitate data review in line with the SANTE guidelines through a stepwise approach of checking retention times, linearity, ion ratios and finally highlighting positively identified samples compared to regulatory values.  Other advantages related to the dual channel LC system will also be discussed.