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Health outcomes depend on complex environmental and sociodemographic factors whose effects change over location and time. Only recently has fine-grained spatial and temporal data become available to study these effects, namely the MEDSAT dataset of English health, environmental, and sociodemographic information. Leveraging this new resource, we use a variety of variable importance techniques to robustly identify the most informative predictors across multiple health outcomes. From there, we develop an interpretable machine learning framework based on Generalized Additive Models (GAMs) and Multiscale Geographically Weighted Regression (MGWR), focusing on these key variables. This framework enables us to analyze both local and global spatial dependencies of each variable on various health outcomes, revealing how these variables behave across regions pre- and post-COVID. Our findings identify NO2 as a global predictor for asthma, hypertension, and anxiety, alongside other significant outcome-specific predictors related to occupation, marriage, length of residence, and vegetation. Regional analyses of health outcomes reveal local variations with air pollution (PM 2.5) and solar radiation, with notable shifts during COVID. This comprehensive approach provides valuable insights for addressing health disparities across England, and advocates for the integration of interpretable machine learning in public health.
