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Translation elongation is essential for cellular proteostasis and is implicated in cancer and neurodegeneration. Accurately predicting the rate of ribosome elongation in each codon (also called ribosomal A site) on mRNA is important for understanding and modulating protein synthesis, which can lead to innovative approaches in treating various diseases. However, predicting elongation rates is challenging due to the trade-off between capturing distal codon interactions and focusing on proximal codon effects at the A site.
Approaches capturing distal codon interactions in the coding sequences (CDS) of mRNA fail to effectively differentiate critical regions (codons near the A site) due to insufficient effective mechanisms for focusing on these regions. Conversely, due to the limitations of models when handling long mRNA sequences, some methods simplify inputs by conditioning solely on proximal codons surrounding the A site, leading to the loss of important information from distal codons. To address this issue, we leverage Mamba&#39;s success in capturing long-range dependencies to enable the consideration of distant codons&#39; impact on the A site. Additionally, we introduce a sliding window attention mechanism to emphasize the proximal codons around the A site during ribosome elongation. Building on these advancements, we present Sliding Window Attention Mamba (SWAMamba), a novel framework that simultaneously leverages both proximal and distal codon effects on the A site. We conduct comprehensive evaluations on ribosome data across four species and find that SWAMamba significantly outperformed current state-of-the-art methods in predicting translation elongation rates.

AAAI 2025

SWAMamba: A Sliding Window Attention Mamba Framework for Predicting Translation Elongation Rates

Translation elongation is essential for cellular proteostasis and is implicated in cancer and neurodegeneration. Accurately predicting the rate of ribosome elongation in each codon (also called ribosomal A site) on mRNA is important for understanding and modulating protein synthesis, which can lead to innovative approaches in treating various diseases. However, predicting elongation rates is challenging due to the trade-off between capturing distal codon interactions and focusing on proximal codon effects at the A site.
Approaches capturing distal codon interactions in the coding sequences (CDS) of mRNA fail to effectively differentiate critical regions (codons near the A site) due to insufficient effective mechanisms for focusing on these regions. Conversely, due to the limitations of models when handling long mRNA sequences, some methods simplify inputs by conditioning solely on proximal codons surrounding the A site, leading to the loss of important information from distal codons. To address this issue, we leverage Mamba's success in capturing long-range dependencies to enable the consideration of distant codons' impact on the A site. Additionally, we introduce a sliding window attention mechanism to emphasize the proximal codons around the A site during ribosome elongation. Building on these advancements, we present Sliding Window Attention Mamba (SWAMamba), a novel framework that simultaneously leverages both proximal and distal codon effects on the A site. We conduct comprehensive evaluations on ribosome data across four species and find that SWAMamba significantly outperformed current state-of-the-art methods in predicting translation elongation rates.

poster

We are pleased to announce the Thirty-Ninth AAAI Conference on Artificial Intelligence (AAAI-25), which will be held in Philadelphia, Pennsylvania at the Pennsylvania Convention Center from February 25 to March 4, 2025.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-25 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

### [Invited Speakers](https://aaai.org/conference/aaai/aaai-25/aaai-25-invited-speakers/)

Register [here](https://aaai.org/conference/aaai/aaai-25/registration/)

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-25 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.



The key to semi-supervised semantic segmentation lies in how to fully exploit a large amount of unlabeled data to improve the model’s generalization performance. Most methods are lured into the trap of taking each class independently (i.e., class-independent consistency) and neglecting the fact that there exist semantic dependencies among classes. In this paper, we analyze the bottlenecks of class-independent consistency inherent in previous methods and offer a fresh perspective of cooperative game theory to explicitly encourage class-consensus alignment (i.e., class-consensus consistency) between the teacher (weak augmented view) and student network (strong augmented view). We formulate classes as players in an interactive game to model their interpretable consensus and shed light on the possibility of closer collaboration between consensus themselves and consistency regularization, yielding more comprehensive and effective supervision signals. To this end, we carefully design the class-consensus consistency without introducing any external knowledge to model class structure information which renders better interpretability, and further, prepend relaxed class-consensus consistency (RCC) to unlock the potential of modeling class consensus by relaxing the strict alignment of direct class consensus values to ranking alignment. Extensive experimental results on multiple benchmarks including mitochondria segmentation demonstrate that RCC performs favorably against state-of-the-art methods. Particularly in the low-data regimes, RCC achieves significant improvements. Code and models will be made available to facilitate future research.

Relaxed Class-consensus Consistency for Semi-supervised Semantic Segmentation

Recently, the success of text-to-image synthesis has greatly advanced the development of identity customization techniques, whose main goal is to produce realistic identity-specific photographs based on text prompts and reference face images. However, it is difficult for existing identity customization methods to simultaneously meet the various requirements of different real-world applications, including the identity fidelity of small face, the control of face location, pose and expression, as well as the customization of multiple persons. To this end, we propose a scale-robust and fine-controllable method, namely RealisID, which learns different control capabilities through the cooperation between a pair of local and global branches. Specifically, by using cropping and up-sampling operations to filter out face-irrelevant information, the local branch concentrates the fine control of facial details and the scale-robust identity fidelity within the face region. Meanwhile, the global branch manages the overall harmony of the entire image. It also controls the face location by taking the location guidance as input. As a result, RealisID can benefit from the complementarity of these two branches. Finally, by implementing our branches with two different variants of ControlNet, our method can be easily extended to handle multi-person customization, even only trained on single-person datasets. Extensive experiments and ablation studies indicate the effectiveness of RealisID and verify its ability in fulfilling all the requirements mentioned above.

RealisID: Scale-Robust and Fine-Controllable Identity Customization via Local and Global Complementation

The enhanced representational power and broad applicability of deep learning models have attracted significant interest from the research community in recent years. However, these models often struggle to perform effectively under domain shift conditions, where the training data (the $\textit{source domain}$) is related to but exhibits different distributions from the testing data (the $\textit{target domain}$). To address this challenge, previous studies have attempted to reduce the domain gap between source and target data by incorporating a few labeled target samples during training—a technique known as semi-supervised domain adaptation (SSDA). While this strategy has demonstrated notable improvements in classification performance, the network architectures used in these approaches primarily focus on exploiting the $\textit{features}$ of individual images, leaving room for improvement in capturing rich representations. In this study, we introduce a Hierarchical Graph of Nodes designed to simultaneously present representations at both $\textit{feature}$ and $\textit{category}$ levels. At the $\textit{feature level}$, we introduce a local graph to identify the most relevant patches within an image, facilitating adaptability to defined main object representations. At the $\textit{category level}$, we employ a global graph to aggregate the features from samples within the same category, thereby enriching overall representations. Extensive experiments on widely used SSDA benchmark datasets, including $\textit{Office-Home}$, $\textit{DomainNet}$, and $\textit{VisDA2017}$, demonstrate that both quantitative and qualitative results substantiate the effectiveness of HiGDA, establishing it as a new state-of-the-art method.

HiGDA: Hierarchical Graph of Nodes to Learn Local-to-Global Topology for Semi-Supervised Domain Adaptation

Leveraging its robust linear global modeling capability, Mamba has notably excelled in computer vision. Despite its success, existing Mamba-based vision models have overlooked the nuances of event-driven tasks, especially in video reconstruction. Event-based video reconstruction (EBVR) demands spatial translation invariance and close attention to local event relationships in the spatio-temporal domain. Unfortunately, conventional Mamba algorithms apply static window partitions and standard reshape scanning methods, leading to significant losses in local connectivity. To overcome these limitations, we introduce EventMamba—a specialized model designed for EBVR task. EventMamba innovates by incorporating random window offset (RWO) in the spatial domain, moving away from the restrictive fixed partitioning. Additionally, it features a new consistent traversal serialization approach in the spatio-temporal domain, which maintains the proximity of adjacent events both spatially and temporally. These enhancements enable EventMamba to retain Mamba’s robust modeling capabilities while significantly preserving the spatio-temporal locality of event data. Comprehensive testing on multiple datasets shows that EventMamba markedly enhances video reconstruction, drastically improving computation speed while delivering superior visual quality compared to Transformer-based methods.

EventMamba: Enhancing Spatio-Temporal Locality with State Space Models for Event-Based Video Reconstruction

Supervised multimodal classification has been proven to outperform unimodal classification in the image-text domain. However, this task highly relies on abundant labeled data. To perform multimodal classification in data-insufficient scenarios, in this study, we explore semi-supervised multimodal classification (SSMC) that only requires a small amount of labeled data and plenty of unlabeled data. 
Specifically, we first design baseline SSMC models by combining known semi-supervised pseudo-labeling methods with the two most commonly used modal fusion strategies, i.e. feature-level fusion and label-level aggregation. Based on our investigation and empirical study of the baselines, we discover two complementarities that may benefit SSMC if properly exploited: the predictions from different modalities (modal complementarity) and modal fusion strategies for pseudo-labeling (strategic complementarity). Therefore, we propose a learning from Modal and Strategic Complementarity (MSC) framework for SSMC. Concretely, to exploit modal complementarity, we propose to learn reliability weights to weigh the predictions from different modalities and refine the fusion scores. To learn from strategic complementarity, we introduce a dual KL divergence loss to guide the balance of quantity and quality of pseudo-labeled data selection. Extensive empirical studies demonstrate the effectiveness of the proposed framework.

Semi-Supervised Multimodal Classification Through Learning from Modal and Strategic Complementarities

Oriented object detection is crucial for complex scenes such as aerial images and industrial inspection, providing precise delineation by minimizing background interference. Recently, the weakly-supervised detector paradigm H2RBox has demonstrated promise in learning rotated bounding box (RBox) from the more readily available horizontal bounding box (HBox), alleviating the scarcity and high cost of RBox annotations. However, these H2RBox-based methods have primarily focused on the gap in orientation information between HBox-supervised and RBox-supervised approaches, overlooking the gap in training sample selection. In response, we propose the Adaptive Fine-grained Sample Mining (AFSM) strategy, which improves the selection of fine-grained training samples in HBox-supervised methods. AFSM assigns the best-matching prediction RBox to each ground truth (GT) HBox and selects positive samples based on these paired boxes. Furthermore, to effectively filter the best-matching prediction RBox for AFSM, we introduce the Prediction Rbox Assignment (PRA) scheme, employing Kullback-Leibler Divergence (KLD) as a localization quality metric. Additionally, we introduce an improved self-supervised branch loss ($L_{ss^*}$) to address the symmetry of weakly-supervised branch prediction boxes. Incorporating these core components (AFSM, PRA, and $L_{ss^*}$), we develop an end-to-end network architecture (BGHR) to further bridge the gap between HBox- and RBox-supervised oriented object detection. Extensive experiments on DOTA-v1.0 and DIOR-R demonstrate that BGHR achieves state-of-the-art performance compared to HBox-supervised methods without additional overhead. Even when benchmarked against fully supervised FCOS, our method still exhibits a slight performance advantage.

BGHR: Bridging the Gap Between HBox-Supervised and RBox-Supervised Oriented Object Detection via Adaptive Fine-Grained Sample Mining

Text-driven Human-Object Interaction (Text-to-HOI) generation is an emerging field with applications in animation, video games, virtual reality, and robotics. A key challenge in HOI generation is maintaining interaction consistency in long sequences. Existing Text-to-Motion-based approaches, such as discrete motion tokenization, cannot be directly applied to HOI generation due to limited data in this domain and the complexity of the modality. To address the problem of interaction consistency in long sequences, we propose an autoregressive diffusion model (ARDHOI) that predicts the next continuous token. Specifically, we introduce a Contrastive Variational Autoencoder (cVAE) to learn a physically plausible space of continuous HOI tokens, thereby ensuring that generated human-object motions are realistic and natural. For generating sequences autoregressively, we develop a Mamba-based context encoder to capture and maintain consistent sequential actions. Additionally, we implement an MLP-based denoiser to generate the subsequent token conditioned on the encoded context. Our model has been evaluated on the OMOMO and BEHAVE datasets, where it outperforms existing state-of-the-art methods in terms of both performance and inference speed. This makes ARDHOI a robust and efficient solution for text-driven HOI tasks. We will make the model weights and source code publicly available.

Auto-Regressive Diffusion for Generating 3D Human-Object Interactions

The application of solutions to time-varying problems is crucial for predicting changes in human body shape over time. While recurrent neural networks have made significant strides in this area, their reliance on centralized processing leads to challenges such as model silos and data isolation. Consequently, distributed artificial intelligence systems, such as federated learning, have emerged to facilitate dynamic collaboration among different models; however, they still depend on a central server, posing significant risks to system security and efficiency. Furthermore, traditional FL primarily supports homogeneous models and lacks effective solutions for interactions among heterogeneous models. To address these limitations, we propose a novel method called the Dynamic Collaboration of Heterogeneous Models (DCHM), which leverages a consortium blockchain network to enhance the credibility of the overall model and facilitate effective coordination among diverse models. Additionally, we introduce a Distributed Hierarchical Aggregation (DHA) algorithm that enables permissioned nodes within each group to aggregate local model results and share these with all permissionless nodes for standardized processing. Following several iterative cycles, permissioned nodes conduct a secondary integration of local results to produce a global outcome. Experimental results demonstrate that DCHM excels in efficiency when analyzing the time-varying nature of body shape changes.

DCHM: Dynamic Collaboration of Heterogeneous Models for Analyzing Time-Varying Body Shape Changes Using a Blockchain-Based Framework

Scene-level point cloud registration is very challenging when considering dynamic foregrounds. Existing indoor datasets mostly assume rigid motions, so the trained models cannot robustly handle scenes with non-rigid motions. On the other hand, non-rigid datasets are mainly object-level, so the trained models cannot generalize well to complex scenes. This paper presents HybridReg, a new approach to 3D point cloud registration, learning uncertainty mask to account for hybrid motions: rigid for backgrounds and non-rigid/rigid for instance-level foregrounds. First, we build a scene-level 3D registration dataset, namely HybridMatch, designed specifically with strategies to arrange diverse deforming foregrounds in a controllable manner. Second, we account for different motion types and formulate a mask-learning module to alleviate the interference of deforming outliers. Third, we exploit a simple yet effective negative log-likelihood loss to adopt uncertainty to guide the feature extraction and correlation computation. To our best knowledge, HybridReg is the first work that exploits hybrid motions for robust point cloud registration. Extensive experiments show HybridReg's strengths, leading it to achieve state-of-the-art performance on both widely-used indoor and outdoor datasets. Code and dataset will be released to facilitate future research.

HybridReg: Robust 3D Point Cloud Registration with Hybrid Motions

In vision transformers, position embedding (PE) plays a crucial role in capturing the order of tokens. However, in vision transformer structures, there is a limitation in the expressiveness of PE due to the structure where position embedding is simply added to the token embedding. A layer-wise method that delivers PE to each layer and applies independent LNs for token embedding and PE has been adopted to overcome this limitation. In this paper, we identify the conflicting result that occurs in a layer-wise structure when using the global average pooling (GAP) method instead of the class token. To overcome this problem, we propose MPVG, which maximizes the effectiveness of PE in a layer-wise structure with GAP. Specifically, we identify that PE counterbalances token embedding values at each layer in a layer-wise structure. Furthermore, we recognize that the counterbalancing role of PE is insufficient in the layer-wise structure, and we address this by maximizing the effectiveness of PE through MPVG. Through experiments, we demonstrate that PE performs a counterbalancing role and that maintaining this counterbalancing directionality significantly impacts vision transformers. As a result, the experimental results show that MPVG outperforms existing methods across vision transformers on various tasks.

SWAMamba: A Sliding Window Attention Mamba Framework for Predicting Translation Elongation Rates

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Relaxed Class-consensus Consistency for Semi-supervised Semantic Segmentation

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SWAMamba: A Sliding Window Attention Mamba Framework for Predicting Translation Elongation Rates

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Next from AAAI 2025

Relaxed Class-consensus Consistency for Semi-supervised Semantic Segmentation

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PRESENTATIONS

CONFERENCES

COMPANY

RESOURCES

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