United States

Abstract Title: 
Sex Disparities in a Telestroke Network: From Treatment Times to Outcomes

Background: The structure of the stroke care delivery system in rural South Carolina has been changed by the Medical University of South Carolina tele-stroke program with &gt;40 spoke sites with improved treatment times and outcomes overall but disparities at the level of primary stroke centers and acute stroke ready hospitals have not been well studied. The aim of this study is to retrospectively analyze data from the tele-stroke network for sex differences in stroke care processes at spoke sites to identify disparities in treatment times and outcomes between men and women. 

Methods: Data were collected and analyzed for 21,549 patients between 1/1/2012 and 12/31/2022 for whom a telestroke was paged out. Statistical analysis was completed using SPSS version 28 (IBM corporation, Armonk, NY). Variables with continuous outcomes were assessed using independent samples median tests and categorical variables were assessed using X².

Results: Of 10,713 (49.7%) males and 10,836 (50.3%) females, females were older (68.29±15.5 vs 66.09±13.7, p&lt;0.01) and more likely to be African American (20.4% vs16.8%, p&lt;0.05) as compared to males. Females were more likely to get thrombolytic therapy (29.06% vs 27.2%, p&lt;0.05) but there was no difference in endovascular therapy between both sexes. Treatment times showed that door-to-registration timing (F: 18±27 vs M: 17±26, p&lt;0.05) and door-to-telestroke page timing (F: 22±27 vs M: 20±26, p&lt;0.05) was significantly higher in females compared to males with ultimately door to needle time having the expected disparity between men and women (F: 59±36 vs M: 55±35, p&lt;0.05). Women also had significantly higher mean discharge NIHSS (M: 4.17±6.20 vs F: 4.61±6.70 (p&lt;0.001) and mRS score (M:2.24±1.93 vs F:2.43±1.95 (p&lt;0.001)). More males were discharged home (62.4% vs 60.4%, (p&lt;0.001), and more females were discharged to nursing homes (8.1% vs 6.2%, p&lt;0.001) and hospice (3.9% vs 2.9%, p&lt;0.001) post admission.

Conclusion: Females are older at stroke onset, have longer treatment times, and have poorer outcomes and discharge dispositions. Our findings highlight the opportunities to ameliorate sex disparities in developing telestroke networks in the United States. Future studies should target these disparities to improve outcomes.


AMA Research Challenge 2024 

Sex Differences in a Telestroke Network: Form Risk Factors to Outcomes

Abstract Title: 
Sex Disparities in a Telestroke Network: From Treatment Times to Outcomes

Background: The structure of the stroke care delivery system in rural South Carolina has been changed by the Medical University of South Carolina tele-stroke program with >40 spoke sites with improved treatment times and outcomes overall but disparities at the level of primary stroke centers and acute stroke ready hospitals have not been well studied. The aim of this study is to retrospectively analyze data from the tele-stroke network for sex differences in stroke care processes at spoke sites to identify disparities in treatment times and outcomes between men and women. 

Methods: Data were collected and analyzed for 21,549 patients between 1/1/2012 and 12/31/2022 for whom a telestroke was paged out. Statistical analysis was completed using SPSS version 28 (IBM corporation, Armonk, NY). Variables with continuous outcomes were assessed using independent samples median tests and categorical variables were assessed using X².

Results: Of 10,713 (49.7%) males and 10,836 (50.3%) females, females were older (68.29±15.5 vs 66.09±13.7, p<0.01) and more likely to be African American (20.4% vs16.8%, p<0.05) as compared to males. Females were more likely to get thrombolytic therapy (29.06% vs 27.2%, p<0.05) but there was no difference in endovascular therapy between both sexes. Treatment times showed that door-to-registration timing (F: 18±27 vs M: 17±26, p<0.05) and door-to-telestroke page timing (F: 22±27 vs M: 20±26, p<0.05) was significantly higher in females compared to males with ultimately door to needle time having the expected disparity between men and women (F: 59±36 vs M: 55±35, p<0.05). Women also had significantly higher mean discharge NIHSS (M: 4.17±6.20 vs F: 4.61±6.70 (p<0.001) and mRS score (M:2.24±1.93 vs F:2.43±1.95 (p<0.001)). More males were discharged home (62.4% vs 60.4%, (p<0.001), and more females were discharged to nursing homes (8.1% vs 6.2%, p<0.001) and hospice (3.9% vs 2.9%, p<0.001) post admission.

Conclusion: Females are older at stroke onset, have longer treatment times, and have poorer outcomes and discharge dispositions. Our findings highlight the opportunities to ameliorate sex disparities in developing telestroke networks in the United States. Future studies should target these disparities to improve outcomes.

poster

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Introduction: Solid-organ transplant recipients (SOTRs) have a higher burden of gynecological cancers as compared to the general population and are likely to develop high-risk oncogenic HPV types due to immunosuppressive therapy. The objective of this study is to evaluate HPV vaccine awareness and uptake among SOTRs, and current attitudes toward the vaccine amongst SOTR care providers.

Methods: This cross-sectional prospective study surveyed SOTR patients and their medical providers on HPV awareness and vaccination (IRB ID: APP-23-00356) at the USC Dermatology clinic and Keck Hospital between April 2023 to May 2024. 

Results: Forty percent (36/91) of patients completed the survey, of whom 18 (50%) knew that HPV is preventable with vaccination and twenty-two (61.1%) participants believed they were at an increased risk for HPV infection. Four (11.1%) participants said their providers recommended the HPV vaccine and four patients (11.1%) reported having received the vaccine. 

Fifty-nine percent of providers (17/ 29) completed the survey, of whom seven (41.2%) providers recommend the HPV vaccine for their SOTR patients. Five (29.4%) providers discuss HPV vaccination status with their SOTR patients, and two (11.8%) stated that they offer the vaccine in their clinic.

Conclusions: Despite a majority of patients believing themselves to be at increased risk for HPV infection, only a minority of patients reported receiving HPV vaccine. Correspondingly, few SOTR care providers offered the HPV vaccine to patients. Our survey highlights the need to increase HPV vaccine access and improve provider guidance for HPV vaccination in SOTRs.


HPV Awareness and Vaccination Among Solid Organ Transplant Patients and Providers

This research investigates the role of time since trauma (TST) in refining trauma team activation (TTA) criteria at a level I trauma center. A retrospective analysis of 1,261 patients presenting after motor vehicle accidents from 2016 to 2021 was conducted, focusing on the relationship between TST and post-emergency department (ED) disposition. The study found that TTA rates decreased with increasing TST, yet patients with a TST of two or more hours showed higher rates of admission, ICU utilization, and surgical interventions. These findings challenge the assumption that TTA need diminishes over time and suggest that current criteria may benefit from refinement to account for longer TST.

Time Delay in Motor Vehicle Accident Arrival Time: A Critical Analysis of Trauma Team Activation

Abstract Title
A Survey on Disabilities and Disability Awareness in General Surgery Residents in the US

Background
Disabilities pose challenges for medical professionals, including surgical residents, impacting their training, performance, and overall well-being. Despite national statistics highlighting the high prevalence of disabilities among adults in the US, there remains a notable gap in understanding how these conditions impact surgical residency programs, particularly regarding the disclosure of disabilities and the utilization of accommodations. This study compared disability prevalence among general surgery residents with national benchmarks, explored disclosure barriers, and assessed disability policies in residency programs.

Methods
This study utilized a descriptive cross-sectional survey conducted among 198 general surgery residents across 323 programs located in urban, suburban, and rural settings. Participants completed a detailed 33-item questionnaire that encompassed demographic data, disability status, practices of disclosure, usage of accommodations, and awareness levels regarding disability policies and training within their residency programs. The survey was administered anonymously via email over two months, from February to April 2024.

Results
Among the respondents, 10.6% reported having physical disabilities, while 20.2% reported mental disabilities; the majority, 68.7%, reported no disabilities. Notably, 62.9% of residents with disabilities had not disclosed their status to program directors, primarily citing fears of discrimination and concerns over the burden of proof. Residents expressed significant apprehension regarding the transparency of accommodation requests and potential biases in evaluations. Moreover, a substantial portion (53.3%) reported receiving no prior training on interacting with individuals with disabilities, and 75.3% were unaware of their residency program's specific disability policies. These findings underscore critical deficiencies in disability
awareness, policy communication, and support mechanisms within surgical residency programs across the United States.

Conclusion
This study highlights pervasive gaps in disability disclosure and support within US surgical residency programs, emphasizing the urgent need for reform. Despite about 1 in 3 surgical residents reporting a disability, disability support seems lacking, impacting the health and wellbeing of residents. Recommendations include integrating comprehensive disability-related training into residency curricula, enhancing transparency of disability policies during the application process, and establishing clear protocols for residents to request accommodations. Addressing these challenges is crucial not only for promoting inclusivity and reducing stigma but also for enhancing professional success and overall well-being of surgical residents with disabilities. Such improvements have the potential to elevate standards of patient care and enhance surgical outcomes. Future research should aim to expand the scope of investigation to include a larger and more diverse sample, as well as explore intersectional factors influencing the accommodation needs of residents with disabilities.

A Survey on Disabilities and Disability Awareness in General Surgery Residents in the US

Background
Antisocial Personality Disorder (ASPD) is one of the most stigmatized psychiatric diagnoses in the public sphere, contrasting with Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD), which are among the least stigmatized. ASPD stigma extends to healthcare, where many providers hold negative attitudes towards patients with ASPD, affecting their willingness to work with this population. Understanding whether medicine perpetuates this stigma is crucial for early intervention in medical training. Given the role of language in perpetuating stigma, as evident in studies on Opioid Use Disorder, this study explored how language contributes to negative attitudes about ASPD in healthcare, an area largely overlooked in stigma research, Psychiatry, and medical education. It aimed to assess medical education resources for stigmatizing language and compare how they reflect public stigma patterns, where ASPD is more stigmatized than MDD and GAD.

Methods
Seven widely used medical education resources were analyzed for their depiction of ASPD, MDD, and GAD. Since many medical students favor third-party resources for studying and board exams, the analysis included Boards and Beyond, AMBOSS, First Aid, First Aid for Psychiatry Clerkship, and APA, as well as in-house materials from Warren Alpert Medical School and the DSM-5. The analysis focused on two stigma components identified by Phelan and Link: labeling and status loss, particularly through clinical pessimism. Fisher's Exact Test compared ASPD to MDD and GAD across labeling, treatment difficulty, and treatment omission.

Results
The analysis revealed significant stigma toward ASPD, with 85.7% (n=6) of the materials using labels like "bad," "manipulative," and "deceitful." Notably, "bad" was used as a mnemonic. In contrast, none of the materials for MDD or GAD employed such labels (p = 0.046). Regarding status loss, 42.9% (n=3) of ASPD materials emphasized treatment difficulty, compared to none for MDD or GAD (p = 0.031). Additionally, 71.4% (n=5) of ASPD resources omitted information on available treatments, while 42.9% (n=3) did so for MDD and GAD. Although the difference in treatment omission was not statistically significant (p = 1.0), the trend still reflects a bias.

Conclusion
The findings suggest that medical education promotes ASPD stigma, mirroring the disproportionate stigma seen in the general public. The use of stigmatizing language indicates that medical education may perpetuate negative attitudes among healthcare providers. Addressing this stigma is crucial to improving care and outcomes for individuals with ASPD. Further research is needed to explore causality and develop strategies to reduce stigma in medical training.

Stigma in Psychiatry Education: A Comparative Analysis of ASPD, MDD, and GAD

ChatGPT and other large language models (LLM) present a promising avenue for enhancing medical education due to its advanced text comprehension and generation capabilities. Motivated by the skyrocketing use of ChatGPT and the lack of curricular mention or discussion on how to best utilize LLMs in medical school, this study investigates the integration of ChatGPT into medical education through a single-session workshop.
Methods
Fifty-nine students from the Emory School of Medicine, 80% first- and second-year medical students and 20% physician assistant students, voluntarily participated in a ChatGPT workshop—a one hour session with learning objectives to understand the framework and construction of a LLM (ChatGPT) and develop comfort in using ChatGPT within medical contexts by generating relevant responses to medical queries in simulated scenarios. Thirty minutes was allocated toward a lecture style presentation and another thirty minutes to hands-on use of ChatGPT. Surveys administered before, immediately after, and eight weeks post-workshop assessed participants' comfort with and likelihood of using ChatGPT, as well as their perceptions of its utility in their future medical careers, ranked on a Likert scale.
Results
ChatGPT usage rose from “never used” and “rare” usage for 76% of participants to usage at least one time per week for 82% of participants at 8 weeks post-workshop, with 23% using ChatGPT four or more days per week. Survey results revealed a significant increase in participants' comfort with using ChatGPT immediately after the workshop, with this improvement persisting at the eight-week follow-up (p<0.05). Moreover, participants reported a significantly higher likelihood of utilizing ChatGPT in their future medical practice after attending the workshop (p<0.05) with the greatest proportion of individuals, 64%, using ChatGPT for explanations of pathophysiology.
Conclusion
This workshop highlights the effectiveness and need of education and training in fostering understanding and utilization of AI technologies like ChatGPT. Despite initial hesitancy, participants demonstrated increased comfort and willingness to incorporate ChatGPT into their medical education and practice. The study underscores the potential of integrating ChatGPT into medical curricula to enhance learning experiences, promote interdisciplinary collaboration, and foster critical thinking skills among students. Additionally, it emphasizes the need for further research to explore the long-term impact and ethical considerations of integrating AI technologies into medical education. Overall, integrating ChatGPT into medical education holds significant implications for the future of healthcare training and practice.

Integrating ChatGPT into Medical Education: A Workshop-Based Approach

Background
Clinical simulations have an important role in medical education, allowing students to gain realistic clinical experience in a didactic manner to improve patient interaction and clinical reasoning skills. However, access to simulations is often limited by resources including physical space in simulation centers and time with standardized patients. ChatGPT is a large language model (LLM) artificial intelligence software that is freely accessible online, that has garnered significant attention in the medical community for its ability to generate relatively accurate medical information. We evaluated the ability of ChatGPT to create high-fidelity virtual clinical simulations and provide simulated patient information and feedback across several clinical scenarios.

Methods
We prompted ChatGPT to generate seven clinical scenarios (fractured arm/intimate partner violence, acute appendicitis, aortic dissection, acetaminophen overdose, acute seizure/metastatic lung cancer, COPD exacerbation, and tension pneumothorax) and create interactive simulations including simulated patient history, physical exam discoveries, lab findings, and imaging descriptions. Each scenario was concluded with feedback and repeated in triplicate to assess consistency. Simulation scenarios were graded for fidelity, evaluated by accuracy, realism, and consistency on a 5-point Likert scale (1-2 = poor, 2-3 = low, 3-4 = moderate, 4-5 = high) by three independent physicians holding the academic rank of Full Professor. A one-sample Wilcoxon signed-rank test was used to assess simulation performance based on a threshold criteria of greater than three out of five points. Fleiss’ Kappa was used to assess interrater reliability. All hypothesis testing was performed using a significance level of p<0.05.

Results
Of the seven simulations evaluated, four were rated high fidelity, two were rated borderline high fidelity, and one was rated moderate fidelity regarding simulation accuracy, realism, and consistency. The mean overall score was 4.0, indicating overall high accuracy, realism, and consistency, significantly higher than hypothesized threshold of 3.0 (p < 0.001). There was a high degree of interrater agreement (ordinal weighted Fleiss κ, 0.763; 95%CI: 0.25-1.0, p<0.05).

Conclusion
Overall, ChatGPT was able to consistently generate accurate and consistent virtual clinical simulations. Our study highlights a framework for a novel use case of LLMs in medical education and demonstrates its utility in providing increased accessibility to simulations for medical students. Although LLMs have known limitations in information accuracy, with the rapid advancement of artificial intelligence technology and advent LLMs that can be trained on specific resources, the use of LLMs such as ChatGPT for further simulation-based medical education represents a promising frontier for medical education.

Evaluating the Utility of a Large Language Model in Simulation-Based Medical Education

Background
Implicit bias, or unconscious attitudes towards minoritized groups, among healthcare providers can contribute to disparities in care, health status, and mortality for minoritized patients. One approach to mitigating the negative effects of these biases on patient care is by implementing anti-racism/anti-bias training into medical education. 

Methods
Rising third year medical students participated in a student-led implicit bias and microaggression training program, including experiential learning through standardized patient (SP) encounters and self-reflection via student-led debrief sessions. The SP encounters simulated instances of xenophobia and perceived language barriers in a hospital setting, in which students were expected to address microaggressions in real time utilizing the VITALS (Validate, Inquire, Take time, Assume the best, Leave opportunities, Speak up for others) framework. Participants completed surveys on attitudes regarding implicit bias prior to participating in the program (T1), after the VITALS video presentation (T2), and after the SP encounter and debrief sessions (T3); surveys were adapted from the VITALS study. 

Results
200 students participated in the program of which 135 linked survey sets were collected for all three time points for data analysis. Results showed that from T1 to T3, there were significant improvements in empathy with targets of bias, comfort in sharing experiences and knowledge and skills to counteract microaggressions. There were no differences by race/ethnicity, language exposure, or religious adherence.

Conclusion
Our implicit bias training, equipped students with the tools and practice needed to interrupt microaggressions in the clinical setting and helped improve their understanding and likelihood of engaging in anti-racism allyship.

Efficacy of Standardized Patient Encounters to Reinforce Implicit Bias Training in the Clinical Setting

Background
In recent years, active learning methods have gained attention for improving material retention and teamwork, especially in education. Despite such benefits, learner engagement remains a challenge, prompting exploration into innovative solutions like game-based instruction. By using game principles, educators can sustain learner interest and encourage participation. Building on these principles, the Texas Health Presbyterian Dallas Internal Medicine Residency program implemented a “House Cup” system where points were awarded for educational activities to promote friendly competition and active learning.

Methods
Residents were evenly distributed into six teams. Points were earned based on criteria including: number of admissions on call days, attendance at lectures, Medical Knowledge Self Assessment Program (MKSAP) review, and the number of procedures performed. Data from January through March of 2022, 2023, and 2024 was collected. Surveys were utilized to gather information on the time spent on MKSAP preparation before and after implementation. Qualitative variables were analyzed with chi-square tests; quantitative variables with ANOVA or Kruskal-Wallis. Statistical significance was determined at an alpha level of 0.05.

Results
Prior to the “House Cup” system (pre-group), there was an average of 5.30 admissions (± 1.15). Following implementation (post-group), admissions rose to an average of 7.87 (± 1.68). Lecture attendance remained stable, with a median of 83 (IQR: 70.75-93) in the pre-group and 85 (IQR: 77-93) in the post-group. MKSAP questions completion and review time in the post-group (mode 51+ questions, 4-5 hours) increased compared to the pre-group (mode 0 questions, 0-1 hours). Number of procedures performed in 2024 (54) surpassed both 2022 (7) and 2023 (16).

Conclusion
Our aim was to assess the impact of game-based learning techniques on material retention, engagement, and teamwork within resident education. Integrating game-based learning into educational activities led to increased participation in call day admissions, lecture attendance, MKSAP review, and number of procedures performed. Implementing game-based learning resulted in improved performance across all metrics except lecture attendance, which was already high. These promising results benefit our residency program and offer insights for others seeking to incentivize and motivate residents


Level Up: Exploring the Effectiveness of Game Based Learning in Graduate Medical Education

Abstract Title: Association Between Utilization of Gender-Affirming Care and Insurance Payer, State, and State Policy

Background: Gender-affirming surgery/hormone therapy (GAS/GAHT) play an essential role in improving quality of life for many transgender and gender-diverse (TGD) individuals. Despite increased demand for GAS/GAHT, TGD individuals face many obstacles to care. We investigated the association between utilization rates of GAS/GAHT and insurance payer, state, and state-level nondiscrimination policies, which prohibit health plans from precluding care based on gender identity or expression. With the disparate legislative climate, it is imperative for stakeholders to understand how these factors influence national utilization rates of GAS/GAHT.

Methods: We retrospectively analyzed a cohort of TGD individuals of all ages to characterize GAS/GAHT utilization between 2010-2020 using the PearlDiver-Mariner Database, which contains all-payer claims for 151 million patients in all 50 states and DC. We used binary logistic regressions to evaluate associations between insurance payers (private, Medicaid, Medicare) and GAS/GAHT, while testing for effect modification by individual states. Furthermore, we designed a difference-in-differences analysis to compare GAS/GAHT utilization among those who did and did not live in states that passed policies prohibiting healthcare access discrimination by insurance payers.

Results: 77,366 individuals were included in the study. The distribution of insurance payers was as follows: 77% private, 16% Medicaid, 7% Medicare. GAS/GAHT utilization was highest among the privately insured and lowest among the Medicare subgroups. Individuals covered by Medicaid (OR=0.78,95% CI=0.73-0.83) or Medicare (OR=0.69,95% CI=0.63-0.75) were less likely to undergo GAS compared to the privately insured. Similar differences in GAHT utilization were observed. Effect modification by state was evident in both outcomes. For example, differences in GAHT utilization rates by insurance payers were smaller among those living in Illinois (38% private, 37% Medicaid, 33% Medicare) compared to Idaho (35% private, 15% Medicaid, 23% Medicare). Quasi-experimental analysis suggested that nondiscrimination policies were associated with increased national all-payer treatment utilization, especially GAS, which more than doubled after implementation.

Conclusion: Our study highlights three main findings: 1) Across all states, individuals covered by Medicaid/Medicare received GAS/GAHT less often compared to the privately insured, 2) Some individual states had minimal insurance payer discrepancies in GAS/GAHT utilization, and 3) While these insurance payer differences in utilization remain at the national level, individuals living in states that implemented nondiscrimination policies experienced an increase in GAS/GAHT post-implementation. Overall, nondiscrimination policies implemented in 21 states and DC increased GAS/GAHT utilization, but challenges at the insurance payer and individual state level continue to threaten TGD individuals’ healthcare and lives.

Association Between Utilization of Gender-Affirming Care and Insurance Payer, State, and State Policy

Abstract Title
Analyzing Recruitment Methods to Increase Diversity in Biobank Collections

Background
Biospecimen collection has played an integral role in research by storing valuable data and tissue samples from both patients with diseases, such as cancer and HIV, as well as healthy control specimens for comparison. The results of these studies shed light on the pathogenic processes of diseases, provide risk stratification, validate new diagnostic tools, and develop targeted pharmacotherapies. Including diverse samples from various races, ethnicities, and backgrounds is essential to increase the generalizability of the results of these studies. Traditional university research participants are typically recruited from the student body and surrounding area, which may not accurately represent the demographics of the local population. Our objective was to create a tissue bank from healthy individual blood samples that is representative of the San Antonio, Texas population for use in future research and analyze traditional university research recruitment methods.

Methods
Traditional methods of university recruitment at UT Health San Antonio using campus fliers, posters, emails, and class announcements were implemented. 311 individuals were screened and a total of 101 participants were enrolled. Participants self-reported a medical history without significant health conditions and provided basic demographic information. Tissue samples were acquired from blood draws and then allocated for storage in the repository. Participant demographic data was compared to the 2020 U.S. Census San Antonio population using the chi-squared test. 

Results
There was a statistically significant difference (p < 0.05) from the expected San Antonio demographics and the recruited participants of racial groups (“White/Caucasian”, “Black or African American”, “Asian”, “Native Hawaiian and Other Pacific Islander”, and “Other”) and ethnic groups (“Hispanic/Latino” and “Not Hispanic or Latino”) except for “American Indian/Alaskan Native” (Expected: 2, Actual 2). There was an overrepresentation of participants who identified as “White/Caucasian” (Expected: 61, Enrolled: 78), “Asian” (Expected: 5, Enrolled: 14), and “Not Hispanic or Latino” (Expected: 37, Enrolled: 58). There was an underrepresentation of those who identified as “Black or African American” (Expected: 10, Enrolled: 3) and “Hispanic/Latino” (Expected: 64, Actual 42). Most participants reported “White/Caucasian” (83%).

Conclusion
Advertising research opportunities in universities is an effective way of increasing enrollment at the cost of diversity. The consequences of utilizing tissue samples from a limited demographic could have significant impacts for minorities. To increase the recruitment of the underrepresented, researchers suggest the use of social media, radio advertisements, health fairs, flea markets, churches, community centers, and translated fliers.

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