Background and Introduction: Menstrual irregularities, encompassing a range of issues such as missed periods, irregular cycle lengths, and abnormal bleeding patterns, are a common concern for many individuals. While several factors can contribute to these irregularities, stress has been identified as a significant influencing factor. Stress, a physiological and psychological response to external pressures, can impact the body's hormonal balance, which is crucial for the regular functioning of the menstrual cycle. The hypothalamus, a part of the brain that regulates hormone production, is particularly sensitive to stress, potentially disrupting the release of gonadotropin-releasing hormone (GnRH). This disruption can alter the menstrual cycle, manifesting as irregular periods. Objective: This study aims to investigate the association between stress levels and menstrual irregularities in women, focusing on physical and psychological impacts. Materials and Methods: A cross-sectional study was conducted involving 259 women from different counties surveyed for stress levels and menstrual health. Data were collected using a standardized questionnaire assessing stress scores (Perceived Stress Scale), physical symptoms during stress, painful periods, and menstrual irregularities. Statistical analyses, including t-tests and logistic regression, were performed to determine the relationships between stress and menstrual health outcomes. Results: The t-test results indicated that women experiencing physical symptoms and painful periods during stress had significantly higher stress scores compared to those who did not report these symptoms. Logistic regression analysis showed a statistically significant positive association between stress and menstrual irregularities, with an adjusted odds ratio (aOR) of 2.7 (95% CI: 1.14-6.53) for women experiencing physical symptoms during stress and still having menstrual irregularities. Additionally, women who perceived stress as a major contributor to their menstrual irregularities reported higher stress scores. Conclusions: The findings suggest that stress has a significant physical and psychological impact on menstrual health. Managing stress should be considered an integral part of treatment and intervention strategies for menstrual irregularities. Addressing the physical and psychological aspects of stress can improve menstrual health outcomes. Keywords: Perceived Stress Scale, Menstrual Irregularities, Physical Symptoms, Psychological Impact, Women's Health