Background Fostering cultural competence in medical education and healthcare settings is crucial for treating diverse patient populations. Middle Eastern North African (MENA)-Americans are categorized as White in the U.S. racial categorization, however, their health needs and experiences drastically. To provide culturally appropriate care, there is a need for disaggregated data on the 3.5 million MENA-Americans from White individuals. This literature view aims to highlight the techniques and strategies to advance MENA health, patient education, and cultural competence among healthcare. Methods A comprehensive search using keywords like “MENA,” “Middle Eastern,” “North African,” “health outcomes,” “patient outcomes,” “minority health,” and “medical education” was conducted in PubMed, This yielded 216 papers for consideration. Inclusion criteria focused on studies related to MENA-American health, medical education on MENA health, and culturally competent care for MENA-American individuals. After abstract screening, 90 papers were selected for full-text review, with 22 meeting the inclusion criteria. Results All 22 articles highlight the need for increased cultural education of this minority group, with key cultural factors identified include language and communication (n=9), family and community involvement (n=12), religious practices and dietary needs (n=9), cultural education (n=8), and stigma (n=5). 10 studies highlight the need for integration of traditional cultural practices into healthcare interventions. Only three intervention studies were identified, which included health education classes (n=2) and online interactive patient simulations (n=1). Eighteen studies offered recommendations for potential future health interventions, including culturally tailored prevention programs, recruitment of Arabic-speaking providers, and implementation of cultural training modules. Conclusion This literature review highlights the importance of tailored efforts to improve MENA health, patient and medical education, and cultural competence in healthcare settings. Although research on MENA-American health is limited, there is a growing understanding of the cultural considerations necessary for caring for this community. It is vital to move towards implementing interventions to fill in the gaps that have been highlighted in the literature. Doing so will enhance cultural competence and ultimately improve the care that MENA-Americans receive.