Background: Traditional didactic learning methods often fail to engage students actively, potentially limiting the retention of complex medical knowledge. This study introduces 'Adrenal Disorders Bingo', a game-based learning approach aimed at enhancing the understanding and recall of adrenal disorders among medical students. Methods: This pilot study used a pre- and post-intervention survey with Likert-scale (1-5) responses to measure changes in students' knowledge, engagement, and application abilities regarding adrenal disorders. The game involved nearly 100 clues related to about 20 adrenal conditions. Students identified and matched these clues with their correct diagnoses on a bingo card. Whenever students achieved five matches in a row, they called "bingo." The game was supplemented by a comprehensive quiz and discussion session, promoting second and third-order thinking. Results: The results showed significant improvement in students' confidence and ability to describe symptoms, differentiate between adrenal disorders based on clinical presentations and laboratory findings, and apply their knowledge in clinical scenarios. There was also a notable increase in student engagement and positive feedback on the learning experience. Conclusion: 'Adrenal Disorders Bingo' offers a promising alternative to traditional learning methods, demonstrating potential for improved knowledge retention and engagement among medical students studying adrenal disorders. The interactive nature of the game, which incorporates nearly 100 clues about 20 adrenal conditions, fosters a more engaging and dynamic learning environment. This contrasts with the passive experience of traditional didactic lectures. By incorporating more interactive games into medical education, educators can enhance critical thinking, facilitate deeper understanding, and improve long-term retention of complex medical concepts. This approach not only makes learning more enjoyable but also prepares students to apply their knowledge more effectively in clinical settings. Future curricula should consider integrating similar game-based learning strategies to complement traditional methods, thereby providing a more effective and engaging educational experience.