A keloid arises when the skin’s healing process becomes disorganized. The excessive production of collagen forms a raised thickened scar that extends beyond the boundaries of the original wound (1). Individuals may develop keloids sporadically or be genetically predisposed, however, the abnormal scarring can pose cosmetic and functional challenges for those affected. Given the potential for regrowth or ongoing growth, management can involve a combination of approaches, including surgical excision, laser therapy, radiation therapy, intralesional or topical steroids, cryotherapy, topical silicone, and pressure therapy (2,3). This clinical case report describes the multimodal management of a keloid that developed in an uncommon and unique location, the site of a previous central venous catheter placed at the subclavian vein. The report reviews the patient’s multiple attempts of size reduction, the keloid’s persistent regrowth and enlargement, and the most recent therapeutic approach consisting of surgical excision followed by superficial radiation therapy.