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In recent years, Large Language Models (LLMs) have demonstrated an impressive ability to encode knowledge during pre-training on large text corpora. They can leverage this knowledge for downstream tasks like question answering (QA), even in complex areas involving health topics. Considering their high potential for facilitating clinical work in the future, understanding the quality of encoded medical knowledge and its recall in LLMs is an important step forward. In this study, we examine the capability of LLMs to exhibit medical knowledge recall by constructing a novel dataset derived from systematic reviews -- studies synthesizing evidence-based answers for specific medical questions. Through experiments on the new MedREQAL dataset, comprising question-answer pairs extracted from rigorous systematic reviews, we assess six LLMs, such as GPT and Mixtral, analyzing their classification and generation performance. Our experimental insights into LLM performance on the novel biomedical QA dataset reveal the still challenging nature of this task.

ACL 2024

MedREQAL: Examining Medical Knowledge Recall of Large Language Models via Question Answering

knowledge recall

medical nlp

systematic reviews

biomedical nlp

clinical nlp

question answering

poster

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The 62nd Annual Meeting of the Association for Computational Linguistics (ACL 2024) will take place in Bangkok, Thailand from August 11th to 16th, 2024. Our Virtual Poster Sessions will take place online Thursday, August 22, 2024.

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The 62nd Annual Meeting of the Association for Computational Linguistics (ACL 2024) will take place in Bangkok, Thailand from August 11th to 16th, 2024. More information will be announced soon.

Knowledge graphs (KGs) play a pivotal role in knowledge-intensive tasks across specialized domains, where the acquisition of precise and dependable knowledge is crucial. However, existing KG construction methods heavily rely on human intervention to attain qualified KGs, which severely hinders the practical applicability in real-world scenarios. To address this challenge, we propose a general KG construction framework, named **SAC-KG**, to exploit large language models (LLMs) as **S**killed **A**utomatic **C**onstructors for domain **K**nowledge **G**raph. SAC-KG effectively involves LLMs as domain experts to generate specialized and precise multi-level KGs. Specifically, SAC-KG consists of three components: Generator, Verifier, and Pruner. For a given entity, Generator produces its relations and tails from raw domain corpora, to construct a specialized single-level KG. Verifier and Pruner then work together to ensure precision by correcting generation errors and determining whether newly produced tails require further iteration for the next-level KG. Experiments demonstrate that SAC-KG automatically constructs a domain KG at the scale of over one million nodes and achieves a precision of 89.32%, leading to a superior performance with over 20% increase in precision rate compared to existing state-of-the-art methods for the KG construction task.

SAC-KG: Exploiting Large Language Models as Skilled Automatic Constructors for Domain Knowledge Graph

The advent of Large Language Models (LLMs) has paved the way for complex tasks such as role-playing, which enhances user interactions by enabling models to imitate various characters. However, the closed-source nature of state-of-the-art LLMs and their general-purpose training limit role-playing optimization. In this paper, we introduce RoleLLM, a framework to benchmark, elicit, and enhance role-playing abilities in LLMs. RoleLLM comprises four stages: (1) Role Profile Construction for 100 roles; (2) Context-Based Instruction Generation (Context-Instruct) for role-specific knowledge extraction; (3) Role Prompting using GPT (RoleGPT) for speaking style imitation; and (4) Role-Conditioned Instruction Tuning (RoCIT) for fine-tuning open-source models along with role customization. By Context-Instruct and RoleGPT, we create RoleBench, the first systematic and fine-grained character-level benchmark dataset for role-playing with 168,093 samples. Moreover, RoCIT on RoleBench yields RoleLLaMA (English) and RoleGLM (Chinese), significantly enhancing role-playing abilities and even achieving comparable results with RoleGPT (using GPT-4).

RoleLLM: Benchmarking, Eliciting, and Enhancing Role-Playing Abilities of Large Language Models

Modern generative search engines enhance the reliability of large language model (LLM) responses by providing cited evidence. However, evaluating the answer's attribution, i.e., whether every claim within the generated responses is fully supported by its cited evidence, remains an open problem. This verification, traditionally dependent on costly human evaluation, underscores the urgent need for automatic attribution evaluation methods. To bridge the gap in the absence of standardized benchmarks for these methods, we present \texttt{AttributionBench}, a comprehensive benchmark compiled from various existing attribution datasets. Our extensive experiments on \texttt{AttributionBench} reveal the challenges of automatic attribution evaluation, even for state-of-the-art LLMs. Specifically, our findings show that even a fine-tuned GPT-3.5 only achieves around 80\% macro-F1 under a binary classification formulation. A detailed analysis of more than 300 error cases indicates that a majority of failures stem from the model's inability to process nuanced information, and the discrepancy between the information the model has access to and that human annotators do.

AttributionBench: How Hard is Automatic Attribution Evaluation?

Large language models (LLMs), even when specifically trained to process long input contexts, struggle to capture relevant information located in the middle of their input. This phenomenon has been known as the lost-in-the-middle problem. In this work, we make three contributions. First, we set out to understand the factors that cause this phenomenon. In doing so, we establish a connection between lost-in-the-middle to LLMs' intrinsic attention bias: LLMs exhibit an U-shaped attention bias where the tokens at the beginning and at the end of its input receive higher attention, regardless of their relevance. Second, we mitigate this positional bias through a calibration mechanism, found-in-the-middle, that allows the model to attend to contexts faithfully according to their relevance, even though when they are in the middle. Third, we show found-in-the-middle not only achieves better performance in locating relevant information within a long context, but also eventually leads to improved retrieval-augmented generation (RAG) performance across various tasks, outperforming existing methods by up to 10 percentage point. These findings open up future directions in understanding LLM attention bias and its potential consequences.

Found in the middle: Calibrating Positional Attention Bias Improves Long Context Utilization

Zero-shot translation aims to translate between language pairs not seen during training in Multilingual Machine Translation (MMT) and is widely considered an open problem. A common, albeit resource-consuming, solution is to add as many related translation directions as possible to the training corpus. In this paper, we show that for an English-centric model, surprisingly large zero-shot improvements can be achieved by simply fine-tuning with a very small amount of multi-parallel data. For example, on the EC30 dataset, we obtain up to +21.7 ChrF++ non-English overall improvements (870 directions) by using only 100 multi-parallel samples while preserving English-centric translation quality. This performance exceeds M2M100 by an average of 5.9 ChrF++ in the involved non-English directions. When investigating the size effect of fine-tuning data on translation quality, we found that already a small, randomly sampled set of fine-tuning directions is sufficient to achieve comparable improvements. The resulting non-English performance is close to the complete translation upper bound. Even in a minimal setting---fine-tuning with only one single sample---the well-known off-target issue is almost completely resolved, explaining parts---but not all---of the observed improvements in translation quality.

How Far can 100 Samples Go? Unlocking Zero-Shot Translation with Tiny Multi-Parallel Data

Interactive fiction games have emerged as an important application to improve the generalization capabilities of language-based reinforcement learning (RL) agents. Existing environments for interactive fiction games are domain-specific or time-consuming to generate and do not train the RL agents to master a specific set of skills. In this work, we introduce an interactive environment for self-supervised RL, STARLING, for text-based games that bootstraps the text-based RL agents with automatically generated games (based on the seed set of game ideas) to boost the performance and generalization capabilities to reach a goal of the target environment. These games let the agent hone their skills on a predefined set of tasks. We create and test an environment with 100 games, generated using this automated framework that uses large language models (GPT3) and an interactive fiction game engine (based on Inform7) to provide the user with the ability to generate more games under minimal human supervision. Experimental results based on both the human participants and baseline text-based RL agents reveal that current state-of-the-art text-based RL agents cannot use previously learned skills in new situations at the level humans can. These results enforce STARLING’s potential to serve as a sandbox environment for further research in self-supervised text-based RL.

STARLING: Self-supervised Training of Text-based Reinforcement Learning Agent with Large Language Models

Instruction tuning is critical to large language models (LLMs) for achieving better instruction following and task adaptation capabilities but its success heavily relies on the training data quality. Many recent methods focus on improving the data quality but often overlook the compatibility of the data with the student model being finetuned. This paper introduces Selective Reflection-Tuning, a novel paradigm that synergizes a teacher LLM’s reflection and introspection for improving existing data quality with the data selection capability of the student LLM, to automatically refine existing instruction-tuning data. This teacher-student collaboration produces high-quality and student-compatible instruction-response pairs, resulting in sample-efficient instruction tuning and LLMs of superior performance. Selective Reflection-Tuning is a data augmentation and synthesis that generally improves LLM finetuning and self-improvement without collecting brand-new data. We apply our method to Alpaca and WizardLM data and achieve much stronger and top-tier 7B and 13B LLMs.

Selective Reflection-Tuning: Student-Selected Data Recycling for LLM Instruction-Tuning

In conversational AI, personalizing dialogues with persona profiles and contextual understanding is essential. Despite large language models' (LLMs) improved response coherence, effective persona integration remains a challenge. In this work, we first study two common approaches for personalizing LLMs: textual prompting and direct fine-tuning. We observed that textual prompting often struggles to yield responses that are similar to the ground truths in datasets, while direct fine-tuning tends to produce repetitive or overly generic replies. To alleviate those issues, we propose **S**elective **P**rompt **T**uning (SPT), which softly prompts LLMs for personalized conversations in a selective way. Concretely, SPT initializes a set of soft prompts and uses a trainable dense retriever to adaptively select suitable soft prompts for LLMs according to different input contexts, where the prompt retriever is dynamically updated through feedback from the LLMs. Additionally, we propose context-prompt contrastive learning and prompt fusion learning to encourage the SPT to enhance the diversity of personalized conversations. Experiments on the CONVAI2 dataset demonstrate that SPT significantly enhances response diversity by up to 90%, along with improvements in other critical performance indicators. Those results highlight the efficacy of SPT in fostering engaging and personalized dialogue generation. The SPT model code is [publicly available](https://github.com/hqsiswiliam/SPT) for further exploration.

Selective Prompting Tuning for Personalized Conversations with LLMs

In this paper, we introduce EHR-SeqSQL, a novel sequential text-to-SQL dataset for Electronic Health Record (EHR) databases. EHR-SeqSQL is designed to address critical yet underexplored aspects in text-to-SQL parsing: interactivity, compositionality, and efficiency. To the best of our knowledge, EHR-SeqSQL is not only the largest but also the first medical text-to-SQL dataset benchmark to include sequential and contextual questions. We provide a data split and the new test set designed to assess compositional generalization ability. Our experiments demonstrate the superiority of a multi-turn approach over a single-turn approach in learning compositionality. Additionally, our dataset integrates specially crafted tokens into SQL queries to improve execution efficiency. With EHR-SeqSQL, we aim to bridge the gap between practical needs and academic research in the text-to-SQL domain.

EHR-SeqSQL : A Sequential Text-to-SQL Dataset For Interactively Exploring Electronic Health Records

Clinical text summarization has proven successful in generating concise and coherent summaries. However, these summaries may include unintended text with hallucinations, which can mislead clinicians and patients. Existing methods for mitigating hallucinations can be categorized into task-specific and task-agnostic approaches. Task-specific methods lack versatility for real-world applicability. Meanwhile, task-agnostic methods are not model-agnostic, so they require retraining for different models, resulting in considerable computational costs. To address these challenges, we propose MEDAL, a model-agnostic framework designed to post-process medical hallucinations. MEDAL can seamlessly integrate with any medical summarization model, requiring no additional computational overhead. MEDAL comprises a medical infilling model and a hallucination correction model. The infilling model generates non-factual summaries with common errors to train the correction model. The correction model is incorporated with a self-examination mechanism to activate its cognitive capability. We conduct comprehensive experiments using 11 widely accepted metrics on 7 baseline models across 3 medical text summarization tasks. MEDAL demonstrates superior performance in correcting hallucinations when applied to summaries generated by pre-trained language models and large language models.

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MedREQAL: Examining Medical Knowledge Recall of Large Language Models via Question Answering

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SAC-KG: Exploiting Large Language Models as Skilled Automatic Constructors for Domain Knowledge Graph

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