Domain adaptation aims to enable Large Language Models (LLMs) to generalize domain datasets unseen effectively during the training phase. However, factors such as the size of the model parameters and the scale of training data are general influencers and do not reflect the nuances of domain adaptation performance. This paper investigates the fine-grained factors affecting domain adaptation performance, analyzing the specific impact of `words' in training data on summarization tasks. We propose quantifying dataset learning difficulty as the learning difficulty of generative summarization, which is determined by two indicators: word-based compression rate and abstraction level. Our experiments conclude that, when considering dataset learning difficulty, the cross-domain overlap and the performance gain in summarization tasks exhibit an approximate linear relationship, which is not directly related to the number of words. Based on this finding, predicting a model's performance on unknown domain datasets is possible without undergoing training. Source code and scripts are available at https://github.com/li-aolong/Word-Matters.