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The mining of adverse drug events (ADEs) is pivotal in pharmacovigilance, enhancing patient safety by identifying potential risks associated with medications, facilitating early detection of adverse events, and guiding regulatory decision-making. Traditional ADE detection methods are reliable but slow, not easily adaptable to large-scale operations, and offer limited information. With the exponential increase in data sources like social media content, biomedical literature, and Electronic Medical Records (EMR), extracting relevant ADE-related information from these unstructured texts is imperative. Previous ADE mining studies have focused on text-based methodologies, overlooking visual cues, limiting contextual comprehension, and hindering accurate interpretation. To address this gap, we present a MultiModal Adverse Drug Event (MMADE) detection dataset, merging ADE-related textual information with visual aids. Additionally, we introduce a framework that leverages the capabilities of LLMs and VLMs for ADE detection by generating detailed descriptions of medical images depicting ADEs, aiding healthcare professionals in visually identifying adverse events. Using our MMADE dataset, we showcase the significance of integrating visual cues from images to enhance overall performance. This approach holds promise for patient safety, ADE awareness, and healthcare accessibility, paving the way for further exploration in personalized healthcare.

ACL 2024

Enhancing Adverse Drug Event Detection with Multimodal Dataset: Corpus Creation and Model Development

vision language model

adverse drug event

multimodal

poster

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The 62nd Annual Meeting of the Association for Computational Linguistics (ACL 2024) will take place in Bangkok, Thailand from August 11th to 16th, 2024. Our Virtual Poster Sessions will take place online Thursday, August 22, 2024.

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The 62nd Annual Meeting of the Association for Computational Linguistics (ACL 2024) will take place in Bangkok, Thailand from August 11th to 16th, 2024. More information will be announced soon.

The rapid advancement of Large Language Models (LLMs) in the realm of mathematical reasoning necessitates comprehensive evaluations to gauge progress and inspire future directions. 
Existing assessments predominantly focus on problem-solving from the examinee perspective, overlooking a dual perspective of examiner regarding error identification and correction.
From the examiner perspective, we define four evaluation tasks for error identification and correction along with a new dataset with annotated error types and steps. 
We also design diverse prompts to thoroughly evaluate eleven representative LLMs. 
Our principal findings indicate that GPT-4 outperforms all models, while open-source model LLaMA-2-7B demonstrates comparable abilities to closed-source models GPT-3.5 and Gemini Pro.
Notably, calculation error proves the most challenging error type. 
Moreover, prompting LLMs with the error types can improve the average correction accuracy by 47.9\%. These results reveal potential directions for developing the mathematical reasoning abilities of LLMs.
Our code and dataset is available on https://github.com/LittleCirc1e/EIC.

Evaluating Mathematical Reasoning of Large Language Models: A Focus on Error Identification and Correction

The rapid advancement of Large Language Models (LLMs) has brought about remarkable generative capabilities but also raised concerns about their potential misuse. While strategies like supervised fine-tuning and reinforcement learning from human feedback have enhanced their safety, these methods primarily focus on natural languages, which may not generalize to other domains. This paper introduces CodeAttack, a framework that transforms natural language inputs into code inputs, presenting a novel environment for testing the safety generalization of LLMs. Our comprehensive studies on state-of-the-art LLMs including GPT-4, Claude-2, and Llama-2 series reveal a new and universal safety vulnerability of these models against code input: CodeAttack bypasses the safety guardrails of all models more than 80\% of the time. We find that a larger distribution gap between CodeAttack and natural language leads to weaker safety generalization, such as encoding natural language input with data structures. Furthermore, we give our hypotheses about the success of CodeAttack: the misaligned bias acquired by LLMs during code training, prioritizing code completion over avoiding the potential safety risk. Finally, we analyze potential mitigation measures. These findings highlight new safety risks in the code domain and the need for more robust safety alignment algorithms to match the code capabilities of LLMs.

CodeAttack: Revealing Safety Generalization Challenges of Large Language Models via Code Completion

Scientific data visualization plays a crucial role in research by enabling the direct display of complex information and assisting researchers in identifying implicit patterns. Despite its importance, the use of Large Language Models (LLMs) for scientific data visualization remains rather unexplored. In this study, we introduce MatPlotAgent, an efficient model-agnostic LLM agent framework designed to automate scientific data visualization tasks. Leveraging the capabilities of both code LLMs and multi-modal LLMs, MatPlotAgent consists of three core modules: query understanding, code generation with iterative debugging, and a visual feedback mechanism for error correction. To address the lack of benchmarks in this field, we present MatPlotBench, a high-quality benchmark consisting of 100 human-verified test cases. Additionally, we introduce a scoring approach that utilizes GPT-4V for automatic evaluation. Experimental results demonstrate that MatPlotAgent can improve the performance of various LLMs, including both commercial and open-source models. Furthermore, the proposed evaluation method shows a strong correlation with human-annotated scores.

MatPlotAgent: Method and Evaluation for LLM-Based Agentic Scientific Data Visualization

Text ranking is a critical task in information retrieval. Recent advances in pre-trained language models (PLMs), especially large language models (LLMs), present new opportunities for applying them to text ranking. While supervised fine-tuning (SFT) with ranking data has been widely explored to better align PLMs with text ranking goals, previous studies have focused primarily on encoder-only and encoder-decoder PLMs. Research on leveraging decoder-only LLMs for text ranking remains scarce. An exception to this is RankLLaMA, which uses direct SFT to explore LLaMA’s potential for text ranking. In this work, we propose a two-stage progressive paradigm to better adapt LLMs to text ranking. First, we conduct continual pre-training (CPT) of LLMs on a large weakly-supervised corpus. Second, we perform SFT, and propose an improved optimization strategy building upon RankLLaMA. Our experimental results on multiple benchmarks show that our approach outperforms previous methods in both in-domain and out-domain scenarios.

A Two-Stage Adaptation of Large Language Models for Text Ranking

Model interpretability in toxicity detection greatly profits from token-level annotations. However, currently, such annotations are only available in English. We introduce a dataset annotated for offensive language detection sourced from a news forum, notable for its incorporation of the Austrian German dialect, comprising 4,562 user comments. In addition to binary offensiveness classification, we identify spans within each comment constituting vulgar language or representing targets of offensive statements. We evaluate fine-tuned Transformer models as well as large language models in a zero- and few-shot fashion. The results indicate that while fine-tuned models excel in detecting linguistic peculiarities such as vulgar dialect, large language models demonstrate superior performance in detecting offensiveness in AustroTox.

AustroTox: A Dataset for Target-Based Austrian German Offensive Language Detection

The ancestor of Chinese character – the ancient characters from about 1300 BC to 200 BC are not fixed in their writing glyphs. At the same or different points in time, one character can possess multiple glyphs that are different in shapes or radicals. Nearly half of ancient glyphs have not been deciphered yet. This paper proposes an innovative task of ancient Chinese glyph identification, which aims at inferring the Chinese character label for the unknown ancient Chinese glyphs which are not in the training set based on the image and radical information. Specifically, we construct a Chinese glyph knowledge graph (CGKG) associating glyphs in different historical periods according to the radical semantics, and propose a multimodal Chinese glyph identification framework (MCGI) fusing the visual, textual, and the graph data. The experiment is designed on a real Chinese glyph dataset spanning over 1000 years, it demonstrates the effectiveness of our method, and reports the potentials of each modality on this task. It provides a preliminary reference for the automatic ancient Chinese character deciphering at the glyph level.

Ancient Chinese Glyph Identification Powered by Radical Semantics

This study introduces the Semantic Textual Similarity Pseudo-Label Semi-Supervised Clustering (STSPL-SSC) framework. The STSPL-SSC framework is designed to tackle the prevalent issue of scarce labeled data by combining a Semantic Textual Similarity Pseudo-Label Generation process with a Robust Contrastive Learning module. The process begins with employing k-means clustering on embeddings for initial pseudo-Label allocation. Then we use a Semantic Text Similarity-enhanced module to supervise the secondary clustering of pseudo-labels using labeled data to better align with the real clustering centers. Subsequently, an Adaptive Optimal Transport (AOT) approach fine-tunes the pseudo-labels. Finally, a Robust Contrastive Learning module is employed to foster the learning of classification and instance-level distinctions, aiding clusters to better separate. Experiments conducted on multiple real-world datasets demonstrate that with just one label per class, clustering performance can be significantly improved, outperforming state-of-the-art models with an increase of 1-6% in both accuracy and normalized mutual information, approaching the results of fully-labeled classification.

STSPL-SSC: Semi-Supervised Few-Shot Short Text Clustering with Semantic text similarity Optimized Pseudo-Labels

As humans, we consistently interact with our peers and receive feedback in the form of natural language. This language feedback allows us to maintain appropriate behavior, and rectify potential errors. The question arises naturally: can we use language feedback to align large language models (LLMs)? In contrast to previous research that aligns LLMs with scalar rewards, we present the first systematic exploration of alignment through the lens of language feedback (i.e., judgment). We start with an in-depth investigation of potential methods that can be adapted for aligning LLMs with judgments, revealing that these methods cannot fully capitalize on judgments. To facilitate more effective utilization of judgments, we propose a novel framework, Contrastive Unlikelihood Training (CUT), that allows for fine-grained inappropriate content detection and correction based on judgments. Our results show that, with merely 1317 off-the-shelf judgment data, CUT can beat the 175B DaVinci003 and surpass the best baseline by 50.84 points on AlpacaEval using LLaMA2-13b. CUT can also align LLMs in an iterative fashion using up-to-date model-specific judgments, improving performance from 81.09 to 91.68 points on AlpacaEval using LLaMA2-chat-13b. Further analysis suggests that judgments hold greater potential in LLM alignment than rewards.

Reasons to Reject? Aligning Language Models with Judgments

Recognizing fallacies is crucial for ensuring the quality and validity of arguments across various domains. However, computational fallacy recognition faces challenges due to the diverse genres, domains, and types of fallacies found in datasets. This leads to a highly multi-class, and even multi-label, setup with substantial class imbalance. In this study, we aim to enhance existing models for fallacy recognition by incorporating additional context and by leveraging large language models to generate synthetic data, thus increasing the representation of the infrequent classes. We experiment with GPT3.5 to generate synthetic examples and we examine the impact of prompt settings for this. Moreover, we explore zero-shot and few-shot scenarios to evaluate the effectiveness of using the generated examples for training smaller models within a unified fallacy recognition framework. Furthermore, we analyze the overlap between the synthetic data and existing fallacy datasets. Finally, we investigate the usefulness of providing supplementary context for detecting fallacy types that need such context, e.g., diversion fallacies. Our evaluation results demonstrate consistent improvements across fallacy types, datasets, and generators. The code and the synthetic datasets are all publicly available.

Large Language Models are Few-Shot Training Example Generators: A Case Study in Fallacy Recognition

Paraphrasing of offensive content is a better alternative to content removal and helps improve civility in a communication environment. Supervised paraphrasers; however, rely heavily on large quantities of labelled data to help preserve meaning and intent. They also often retain a large portion of the offensiveness of the original content, which raises questions on their overall usability. In this paper we aim to assist practitioners in developing usable paraphrasers by exploring In-Context Learning (ICL) with large language models (LLMs), i.e., using a limited number of input-label demonstration pairs to guide the model in generating desired outputs for specific queries. Our study focuses on key factors such as - number and order of demonstrations, exclusion of prompt instruction, and reduction in measured toxicity. We perform principled evaluation on three datasets, including our proposed Context-Aware Polite Paraphrase (CAPP) dataset, comprising of dialogue-style rude utterances, polite paraphrases, and additional dialogue context. We evaluate our approach using four closed source and one open source LLM. Our results reveal that ICL is comparable to supervised methods in generation quality, while being qualitatively better by 25% on human evaluation and attaining lower toxicity by 76%. Also, ICL-based paraphrasers only show a slight reduction in performance even with just 10% training data.

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Enhancing Adverse Drug Event Detection with Multimodal Dataset: Corpus Creation and Model Development

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Evaluating Mathematical Reasoning of Large Language Models: A Focus on Error Identification and Correction

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