**WHAT WE HAVE - update on state of the art** **Chairs:** [Sharon DeMorrow](https://underline.io/speakers/145924-sharon-demorrow) (USA) and Christopher Rose (Canada) **Presenter:** [Rocío Gallego-Duran](https://underline.io/speakers/145954-rocio-gallego-duran) (Spain) **Title:** The role of ammonia in progression of fibrosis in liver disease 
 **Presenter:** [Andrea Cabrera-Pastor](https://underline.io/speakers/145944-andrea-cabrera-pastor) (Spain) **Title:** Interaction between hyperammonaemia and glutamate, glutamine and GABA 
 **Presenter:** [Cristina Cudalbu](https://underline.io/speakers/145940-cristina-cudalbu) (Switzerland) **Title:** Brain oedema in persistent hepatic encephalopathy 
 **Presenter:** [Rafael Ochoa-Sanchez](https://underline.io/speakers/145947-rafael-ochoa-sanchez) (Canada) **Title:** The impact of obesity on neurological decline in experimental cirrhosis

SESSION 1: Basic science in hepatic encephalopathy

**WHAT WE HAVE - update on state of the art** **Chairs:** Karin Weissenborn (Germany) and Oliviero Riggio (Italy)
 **Presenter:** [Karen Louise Thomsen](https://underline.io/speakers/145945-karen-louise-thomsen) (Denmark)
 **Title:** Cognitive dysfunction in NAFLD – a new hepatic encephalopathy?
 
 **Presenter:** [Dominique Thabut](https://underline.io/speakers/145955-dominique-thabut) (France)
 **Title:** Ammonia – applications and pitfalls
 
 **Presenter:** [Nicolas Weiss](https://underline.io/speakers/145926-nicolas-weiss) (France)
 **Title:** The neuropsychology of metabolic encephalopathies
 
 **Presenter:** [Christian Labenz](https://underline.io/speakers/145936-christian-labenz) (Germany)
 **Title:** Diabetes (and sleep apnoea) — how do they interact with MHE and MHE diagnostic tools

SESSION 2: Hepatic encephalopathy diagnosis

**WHAT WE HAVE - update on state of the art** **Chairs:** Jasmohan Bajaj (USA) and Piero Amodio (Italy)

 **Presenter:** [Niels Kristian Agaard](https://underline.io/speakers/145949-niels-kristian-muff-aagaard) (Denmark)
 **Title:** Potassium and sodium – innocent bystanders or active contributors to HE
 
 **Presenter:** [Debbie Shawcross](https://underline.io/speakers/145929-debbie-shawcross) (UK)
 **Title:** HE and the gut – how far are we from clinical use?
 
 **Presenter:** [Silvia Nardelli](https://underline.io/speakers/145935-silvia-nardelli) (Italy)
 **Title:** Prevention of post-TIPS HE – nutrition, medication or more careful patient selection? 
 
 **Presenter:** [Wim Laleman](https://underline.io/speakers/145937-wim-laleman) (Belgium)
 **Title:** Closing portosystemic shunts – does it work, and which should we target?

SESSION 3: Hepatic encephalopathy treatment

**WHAT IS HAPPENING - young researchers and short oral communication** **Chairs:** Dieter Haussinger (Germany) and Cristina Cudalbu (Switzerland)

 **Presenter:** [Anna Hadjihambi](https://underline.io/speakers/147490-anna-hadjihambi) (UK)
 **Title:** Rescuing the brain from non-alcoholic fatty liver disease: role of the monocarboxylate transporter-1

 **Presenter:** [Anne Catrine Daugaard Mikkelsen](https://underline.io/speakers145941-anne-catrine-daugaard-mikkelsen) (Denmark)
 **Title:** Cognitive dysfunction is associated with systemic inflammation and neuroinflammation in a rodent model of NASH

 **Presenter:** [Katarzyna Pierzchala](https://underline.io/speakers145950-katarzyna-pierzchala) (Switzerland)
 **Title:** Central Nervous System Oxidative Stress and Inflammation in a rat model of Type C Hepatic Encephalopathy – brothers in arms?

 **Presenter:** [Mariana Oliveira](https://underline.io/speakers/145951-mariana-m.-oliveira) (Canada)
 **Title:** Sex Disparity on the development of HE: impact of ammonia and ROS in the development of brain edema and hepatic encephalopathy severity in BDL rats 
 **Presenter:** [Elaina Williams](https://underline.io/speakers/145946-elaina-williams) (USA) **Title:** Hyperammonemia in type c he induces a scenescent-like phenotype in neurons

SESSION 4: Basic science: Oral abstracts and short oral communications

**WHAT IS HAPPENING - young researchers and short oral communication** **Chairs:** German Soriano (Spain) and Marsha Morgan (UK)

 **Presenter:** [Lyès Kheloufi](https://underline.io/speakers/145933-lyes-kheloufi) (France)
 **Title:** Neuropsychological assessment of hepatic encephalopathy and its contribution to differential diagnosis in a multidisciplinary evaluation of patients with chronic liver disease

 **Presenter:** [Lea Grønkjær](https://underline.io/speakers/145927-lea-ladegaard-gronkjar) (Denmark)
 **Title:** Impaired cognition in morbid obesity is not specifically linked to fatty liver and liver fibrosis severity

 **Presenter:** [Dalia Rega](https://underline.io/speakers/145925-dalia-rega) (Spain)
 **Title:** Characterizing sensory and autonomic dysfunction in cirrhotic patients with minimal hepatic encephalopathy.

 **Presenter:** [Lisa Zarantonello](https://underline.io/speakers/143233-lisa-zarantonello) (Italy)
 **Title:** Working memory in patients with varying degree of hepatic encephalopathy (HE): an EEG-fNIRS study

 **Presenter:** [Mette Lauridsen](https://underline.io/speakers/143232-mette-munk-lauridsen) (Denmark)
 **Title:** Preliminary data on Animal Naming Test in healthy Danes and patients with liver cirrhosis

 **Presenter:** [Henning Pflugrad](https://underline.io/speakers/145928-henning-pflugrad) (Germany)
 **Title:** Brain energy metabolism is altered in patients with posttransplant enecephalopathy after liver transplantation

SESSION 5: HE Diagnosis: Oral abstracts and short oral communications

**WHAT IS HAPPENING - young researchers and short oral communication** **Chairs:** Radha Dhiman (India) and Manuela Merli (Italy)

 **Presenter:** [Marika Rudler](https://underline.io/speakers/145953-marika-rudler) (France)
 **Title:** Pre-emptive TIPS should be performed in high-risk cirrhotic patients with variceal bleeding despite the presence of HE at admission

 **Presenter:** [Jeremy Louissaint](https://underline.io/speakers/145938-jeremy-louissaint) (USA)
 **Title:** An Electronic Decision Support Intervention Reduces Readmissions for Patients with Cirrhosis

 **Presenter:** [Eugene Wong Yu Jun](https://underline.io/speakers/145952-yu-jun-wong) (Singapore)
 **Title:** Efficacy and safety of albumin infusion for overt hepatic encephalopathy: A systematic review and meta-analysis

 **Presenter:** [Patricia Bloom](https://underline.io/speakers/147496-patricia-bloom) (USA)
 **Title:** Effect of Fecal Microbiota Transplant on Hepatic Encephalopathy Varies by Donor and Recipient Factors

 **Presenter:** [Jeffrey Gibbs](https://underline.io/speakers/145943-jeffrey-gibbs) (USA)
 **Title:** The rate of successful extubation in mechanically ventilated patients with cirrhosis and hepatic coma

 **Presenter:** [Diana Evstafeva](https://underline.io/speakers/145942-diana-evstafeva) (Switzerland)
 **Title:** In vitro evaluation of novel urease inhibitors for the treatment of hepatic encephalopathy

SESSION 6: HE Treatment: Oral abstracts and short oral communications

**WHAT WE NEED - a look to the near future of HE prognostication, diagnosis, and treatment** **Chairs:** [Vicente Felipo](https://underline.io/speakers/145931-vicente-felipo) (Spain) and Mark Swain (Canada) ) **Presenter:** [Marta Méndez](https://underline.io/speakers/145930-marta-mendez) (Spain) **Title:** Mitochondrial dysfunction in hepatic encephalopathy **Presenter:** [Matthew McMillin](https://underline.io/speakers/145934-matthew-mcmillin) (USA) **Title:** Astrocytes and microglia to the pathogenesis of hepatic encephalopathy **Presenter:** [Paula Izquierdo-Alterejos](https://underline.io/speakers/148717-paula-izquierdo-alterejos) (Spain) **Title:** The role of extracellular vesicles in the induction of neuroinflammation in hepatic encephalopathy **Presenter:** [Anna Hadjihambi](https://underline.io/speakers/147490-anna-hadjihambi) (UK) **Title:** Altered Brain Lactate Metabolism in HE

SESSION 7: The future in hepatic encephalopathy basic science

**WHAT WE NEED - a look to the near future of HE prognostication, diagnosis, and treatment** **Chairs:** Barjesh Sharma (India) and Manuel Romero-Gomez (Spain) **Presenter:** [Elliot Tapper](https://underline.io/speakers/145956-elliot-tapper) (USA) **Title:** Prediction of future OHE beyond psychometric testing **Presenter:** Esmael Nadimi (Denmark) **Title:** Machine learning in MHE diagnosis - will it be possible? **Presenter:** [James Covington](https://underline.io/speakers/145948james-covington) (UK) and Ramesh Arasaradnam (UK) **Title:** Biomarkers in MHE diagnosis and OHE prediction - blood and breathomics **Presenter:** [Russell Rosenblatt](https://underline.io/speakers/145939-russell-rosenblatt) (USA) **Title:** Remote monitoring of cognition in HE – what are the options?

SESSION 8: The future for hepatic encephalopathy diagnosis

**WHAT WE NEED - a look to the near future of HE prognostication, diagnosis, and treatment** **Chairs:** [Sara Montagnese](https://underline.io/speakers/143231-sara-montagnese) (Italy) and Rob Rahimi (USA)

 **Presenter:** [Torbjörn Bäckström](https://underline.io/speakers/147497-torbjorn-backstrom) (Sweden)
 **Title:** Neurosteroids in HE – potential treatment targets?

 **Presenter:** [Lise Lotte Gluud](https://underline.io/speakers/145932-lise-lotte-gluud) (Denmark)
 **Title:** Pharmaceutical prevention of OHE - what’s the evidence?

 **Presenter:** [Vicente Felipo](https://underline.io/speakers/145931-vicente-felipo) (Spain)
 **Title:** Hyperammonemia and peripheral inflammation induce neuroinflammation that alters neurotransmission and cognitive and motor function in HE: underlying mechanisms and therapeutic implications (Andrés Blei Lecture)

SESSION 9: The future in hepatic encephalopathy treatment

## Welcome to ISHEN 2021!
[ISHEN 2021](https://underline.io/events/189/main-stage) will be a virtual event on 6, 7 and 8th October. 

The first day will focus on state of the art in basic research, diagnosis and treatment of HE. The second will feature young investigators’ work in the same areas. The third day will consider what the field needs for future developments and progress, including the prestigious Andres Blei lecture and the Juan Córdoba Young Investigator Award.

We will not let the pandemic deter us from our social activities. These will be part of the celebrations for the 800-year anniversary of Padova University, and will include a virtual tour of the Great Hall, Galileo’s Chair and the world’s first Anatomical Theatre, dated 1594.

So, albeit remotely and to borrow from Shakespeare, it is a great honour and real pleasure to welcome you to “fair Padua, nursery of arts”. And sciences!

Sara Montagnese
ISHEN President

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ISHEN 2021

Welcome to ISHEN 2021!
ISHEN 2021 will be a virtual event on 6, 7 and 8th October. 


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