Increased expression of Ehmt1 / GLP protein in embryonal neurogenesis, and specific postnatal and adult mouse and rat brain neurogenesis areas

Understanding the spatiotemporal subcellular organization of the human proteome

Introduction: Sarcoidosis is a multisystemic disorder, characterized by the formation of non-caseating granulomas. the mTORC1 signaling pathway is suggested to play a role in granuloma formation. Recent studies demonstrated conflicting data on mTORC1 expression in patiens with sarcoidosis with either 33% or 100% of patients demonstrating mTORC1 activation within the granulomas. Therefore the aim of our study was to reevaluate the percentage of mTORC1 activation in sarcoidosis patients in a Dutch cohort. We also included Dutch patients with other granulomatous disorders of the lung to investigate whether mTORC1 activation can also be found in these diseases. 
Material and methods: This is a retrospective analysis of 74 patients with sarcoidosis and 39 patients with other pulmonary granulomatous disorders such as HP and vasculitiis. The activation of the mTORC1 signaling pathway was evaluated by immunohistochemical staining of its downstream effector p-S6 in tissue sections. 
Results: Active mTORC1 signaling was detected in 32 (43%) of the sarcoidosis patients and in 12 (31%) of the patients with other granulomatous disorders, demonstrating that this pathway is not specific for granuloma formation in sarcoidosis (p=0.628). 
Conclusion: Activation of mTORC1 can be found in a subgroup of patients with sarcoidoiss, as well as in patients with other granulomatous pulmonary disorders such as HP or vasculitis.

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Increased expression of Ehmt1 / GLP protein in embryonal neurogenesis, and specific postnatal and adult mouse and rat brain neurogenesis areas

Understanding the spatiotemporal subcellular organization of the human proteome

Expression of mTOR signaling can be found in a subgroup of Dutch patients with either sarcoidosis, hypersensitiviy pneumonitis or vasculitis

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